Two (Chemo)-enzymatic cascades for the production of opposite enantiomers of chiral azidoalcohols

Multi-step cascade reactions have gained increasing attention in the biocatalysis field in recent years. In particular, multi-enzymatic cascades can achieve high molecular complexity without workup of reaction intermediates thanks to the enzymes’ intrinsic selectivity; and where enzymes fall short, organo-or metal catalysts can further expand...

Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade

Enantioenriched azido alcohols are precursors for valuable chiral aziridines and 1,2-amino alcohols, however their chiral substituted analogues are difficult to access. We established a cascade for the asymmetric azidohydroxylation of styrene derivatives leading to chiral substituted 1,2-azido alcohols via enzymatic asymmetric epoxidation,...

Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols

A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the...

Robust real-time synchronization between textual and graphical editors

This paper is a pre-print of: Oskar van Rest, Guido Wachsmuth, Jim Steel, Jörn Guy Süß, Eelco Visser. Robust Real-Time Synchronization between Textual and Graphical Editors. In Keith Duddy, Gerti Kappel, editors, Theory and Practice of Model Transformations, Sixth International Conference, ICMT 2013, Budapest, Hungary, June 18-19, 2013....