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Paunović, Nevena (author), Bao, Yinyin (author), Coulter, Fergal Brian (author), Masania, K. (author), Geks, Anna Karoline (author), Klein, Karina (author), Rafsanjani, Ahmad (author), Cadalbert, Jasmin (author), Franzen, Daniel (author)Central airway obstruction is a life-threatening disorder causing a high physical and psychological burden to patients. Standard-of-care airway stents are silicone tubes, which provide immediate relief but are prone to migration. Thus, they require additional surgeries to be removed, which may cause tissue damage. Customized bioresorbable airway...journal article 2021
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Haghighi, Z. (author), Dehnavi, Mahboubeh Angali (author), Konstantinou, T. (author), van den Dobbelsteen, A.A.J.F. (author), Klein, T. (author)Researchers have reported that despite technological development in photovoltaic technology and substantial cost reduction, there is still a narrow interest in architectural photovoltaic applications (APA). Lack of interest is correlated to various bottlenecks, and one of them is a lack of knowledge among architects on the possibilities and...journal article 2021
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Li, Bo (author), Niessen, W.J. (author), Klein, Stefan (author), de Groot, Marius (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author), Bron, Esther E. (author)This work presents a single-step deep-learning framework for longitudinal image analysis, coined Segis-Net. To optimally exploit information available in longitudinal data, this method concurrently learns a multi-class segmentation and nonlinear registration. Segmentation and registration are modeled using a convolutional neural network and...journal article 2021
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Angus, Lindsay (author), Starmans, M.P.A. (author), Rajicic, Ana (author), Odink, Arlette E. (author), Jalving, Mathilde (author), Niessen, W.J. (author), Visser, Jacob J. (author), Sleijfer, Stefan (author), Klein, Stefan (author), van der Veldt, Astrid A.M. (author)Patients with BRAF mutated (BRAF-mt) metastatic melanoma benefit significantly from treatment with BRAF inhibitors. Currently, the BRAF status is determined on archival tumor tissue or on fresh tumor tissue from an invasive biopsy. The aim of this study was to evaluate whether radiomics can predict the BRAF status in a non-invasive manner....journal article 2021
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Castillo, J.M. (author), Starmans, M.P.A. (author), Arif, M. (author), Niessen, W.J. (author), Klein, Stefan (author), Bangma, Chris H. (author), Schoots, Ivo G. (author), Veenland, J.F. (author)Radiomics applied in MRI has shown promising results in classifying prostate cancer lesions. However, many papers describe single-center studies without external validation. The issues of using radiomics models on unseen data have not yet been sufficiently addressed. The aim of this study is to evaluate the generalizability of radiomics...journal article 2021
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van Ments, Laila (author), Treur, J. (author), Klein, L.J. (author), Roelofsma, P.H.M.P. (author)This paper describes a network model for mental processes making use of shared mental models (SMM) of team performance. The paper illustrates the value of adequate SMM’s for safe and efficient team performance. The addressed application context is that of a medical team performing a tracheal intubation executed by a nurse and a medical...conference paper 2021
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Huizinga, W. (author), Poot, D.H.J. (author), Vinke, E. J. (author), Wenzel, F. (author), Bron, E. E. (author), Ikram, M. A. (author), Niessen, W.J. (author), Vernooij, M. W. (author), Klein, S. (author)For the segmentation of magnetic resonance brain images into anatomical regions, numerous fully automated methods have been proposed and compared to reference segmentations obtained manually. However, systematic differences might exist between the resulting segmentations, depending on the segmentation method and underlying brain atlas. This...journal article 2021
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Azcarate Aguerre, J.F. (author), Klein, T. (author), den Heijer, A.C. (author)Scientific and professional dissemination of the Facade Leasing Demonstrator Project. This technical report is an annex to the Facade Leasing Demonstrator Project 2019 performance report(2.7.3.FLD.D1). For general information on the Facade Leasing research project, its process, and objectives please refer to the aforementioned document. The...report 2020
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Azcarate Aguerre, J.F. (author), Klein, T. (author), den Heijer, A.C. (author)Incentivising investment and long-term collaboration in high-performance facadeprojects. This technical report is an annex to the Facade Leasing Demonstrator Project 2019 performance report(2.7.3.FLD.D1). For general information on the Facade Leasing research project, its process, and objectives please refer to the aforementioned document. This...report 2020
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Azcarate Aguerre, J.F. (author), Klein, T. (author), den Heijer, A.C. (author)This technical report is an annex to the Facade Leasing Demonstrator Project 2019 performance report(2.7.3.FLD.D1). For general information on the Facade Leasing research project, its process, and objectives please refer to the aforementioned document. This technical delivery report focuses on the design, engineering, construction, and...report 2020
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- Knaack, U. (author), Klein, T. (author) contribution to periodical 2020
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Venkatraghavan, Vikram (author), Klein, S. (author), Fani, Lana (author), Ham, Leontine S. (author), Vrooman, Henri (author), Ikram, M. Kamran (author), Niessen, W.J. (author), Bron, Esther E. (author)Alzheimer's disease (AD) is the most common form of dementia and is phenotypically heterogeneous. APOE is a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM). Since DEBM is a data...journal article 2020
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Koruza, Jurij (author), Zhang, Mao Hua (author), Hadaeghi, Niloofar (author), Egert, Sonja (author), Ding, Hui (author), Zhang, Hongbin (author), Braga Groszewicz, P. (author), Buntkowsky, Gerd (author), Klein, Andreas (author)Antiferroelectric materials exhibit a unique electric-field-induced phase transition, which enables their use in energy storage, electrocaloric cooling, and nonvolatile memory applications. However, in many prototype antiferroelectrics this transition is irreversible, which prevents their implementation. In this work, we demonstrate a general...journal article 2020
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Cremers, Lotte G.M. (author), Huizinga, Wyke (author), Niessen, W.J. (author), Krestin, Gabriel P. (author), Poot, D.H.J. (author), Ikram, M. Arfan (author), Lötjönen, Jyrki (author), Klein, S. (author), Vernooij, Meike W. (author)Background: Identifying persons at risk for cognitive decline may aid in early detection of persons at risk of dementia and to select those that would benefit most from therapeutic or preventive measures for dementia. Objective: In this study we aimed to validate whether cognitive decline in the general population can be predicted with...journal article 2020
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Del Grosso, M. (author), Sridharan, Balaji (author), Tsekos, C. (author), Klein, S.A. (author), de Jong, W. (author)This work is focused on the process system modelling of an indirectly heated gasifier (10 MW<sub>th</sub>) using torrefied wood as feedstock and its integration with methanol and power production using Aspen Plus®. The modelling of the gasification process along with the obtained reaction kinetics were validated with experimental data found...journal article 2020
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Xiberras, Joeline (author), Klein, Mathias (author), de Hulster, A.F. (author), Mans, R. (author), Nevoigt, Elke (author)Previously, our lab replaced the endogenous FAD-dependent pathway for glycerol catabolism in S. cerevisiae by the synthetic NAD-dependent dihydroxyacetone (DHA) pathway. The respective modifications allow the full exploitation of glycerol’s higher reducing power (compared to sugars) for the production of the platform chemical succinic acid ...journal article 2020
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van Valenberg, W. (author), Klein, S. (author), Vos, F.M. (author), Koolstra, Kirsten (author), van Vliet, L.J. (author), Poot, D.H.J. (author)Quantitative MRI methods that estimate multiple physical parameters simultaneously often require the fitting of a computational complex signal model defined through the Bloch equations. Repeated Bloch simulations can be avoided by matching the measured signal with a precomputed signal dictionary on a discrete parameter grid (i.e. lookup table...journal article 2020
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Timbergen, Milea J.M. (author), Starmans, Martijn P.A. (author), Padmos, Guillaume A. (author), Grünhagen, Dirk J. (author), van Leenders, Geert J.L.H. (author), Hanff, D. F. (author), Niessen, W.J. (author), Klein, S. (author), Visser, J.J. (author)Purpose: Diagnosing desmoid-type fibromatosis (DTF) requires an invasive tissue biopsy with β-catenin staining and CTNNB1 mutational analysis, and is challenging due to its rarity. The aim of this study was to evaluate radiomics for distinguishing DTF from soft tissue sarcomas (STS), and in DTF, for predicting the CTNNB1 mutation types....journal article 2020
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Klein, M. (author)The past decade has witnessed a revolution in genome-engineering. Using CRISPR-Cas9 DNA sequences can be marked, detected and cleaved. Rewriting life’s instructions in such a fashion paves the way towards numerous scientific, agricultural and medical applications. Without proper quantfication of the associated risks we face the danger of...doctoral thesis 2019
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Felimban, Ahmed Abdulazeem (author), Prieto Hoces, A.I. (author), Knaack, U. (author), Klein, T. (author), Qaffas, Yasser (author)In the Kingdom of Saudi Arabia (KSA), residential buildings' energy consumption accounts for almost 50% of the building stock electricity consumption. The KSA's economy relies heavily on fossil fuel sources, namely oil reservoirs, whose depletion will negatively affect the future development of the country. The total electricity consumption is...journal article 2019