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Chen, J. (author)Cancer is known as one of the leading causes of death in the world with difficult<br/>diagnose at early stages, poor prognosis and high mortality. Animal-based<br/>experiments and clinical trials have always been the main approach for cancer<br/>research, albeit they may have limitations and ethical issues. Mathematicalmodeling<br/>as an...doctoral thesis 2020
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Chen, J. (author), Weihs, D. (author), Vermolen, F.J. (author)Oncolytic virotherapy is known as a new treatment to employ less virulent viruses to specifically target and damage cancer cells. This work presents a cellular automata model of oncolytic virotherapy with an application to pancreatic cancer. The fundamental biomedical processes (like cell proliferation, mutation, apoptosis) are modeled by the...journal article 2020
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Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)More than eighty percent of pancreatic cancer involves ductal adenocarcinoma with an abundant desmoplastic extracellular matrix surrounding the solid tumor entity. This aberrant tumor microenvironment facilitates a strong resistance of pancreatic cancer to medication. Although various therapeutic strategies have been reported to be effective...journal article 2019
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Chen, J. (author), Weihs, Daphne (author), van Dijk, Marcel (author), Vermolen, F.J. (author)Cell migration plays an essential role in cancer metastasis. In cancer invasion through confined spaces, cells must undergo extensive deformation, which is a capability related to their metastatic potentials. Here, we simulate the deformation of the cell and nucleus during invasion through a dense, physiological microenvironment by developing...journal article 2018