Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease

The detection of genetic loci associated with Alzheimer’s disease (AD) requires large numbers of cases and controls because variant effect sizes are mostly small. We hypothesized that variant effect sizes should increase when individuals who represent the extreme ends of a disease spectrum are considered, as their genomes are assumed to be...

Laparoscopic suturing learning curve in an open versus closed box trainer

Background The aim of this study was to examine the influence of training under direct vision prior to training with indirect vision on the learning curve of the laparoscopic suture task. Methods Novices were randomized in two groups. Group 1 performed three suturing tasks in a transparent laparoscopic box trainer under direct vision followed by...

Quick assessment tool for assurance of structural safety in the building process

From forensic investigation it is known that many structural failures can be attributed to human errors and organizational factors. To provide project leaders with information on the current state of factors in the building process influencing structural safety, we developed a quick assessment tool. Logistic regression was used, based on data of...

Calculation and control of heat transfer in injection moulding

Schema voor de fabricage van n.butylacetaat

Document(en) uit de collectie Chemische Procestechnologie