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Rathnayake, Manula S.B. (author), Boos, Manuela A. (author), Farrugia, Brooke L. (author), van Osch, G.J.V.M. (author), Stok, Kathryn S. (author)Glycosaminoglycans (GAGs) are ubiquitous components in the cartilage extracellular matrix (ECM). Ultrastructural arrangement of ECM and GAG-mediated interactions with collagen are known to govern the mechanics in articular cartilage, but these interactions are less clear in other cartilage types. Therefore, this article reviews the current...review 2024
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Yarali, E. (author), Zadpoor, A.A. (author), Staufer, U. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)Mechanical and morphological design parameters, such as stiffness or porosity, play important roles in creating orthopedic implants and bone substitutes. However, we have only a limited understanding of how the microarchitecture of porous scaffolds contributes to bone regeneration. Meta-biomaterials are increasingly used to precisely engineer...review 2023
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Ndiaye, A.B.E. (author), Koenderink, G.H. (author), Shemesh, M. (author)The mammalian cytoskeleton forms a mechanical continuum that spans across the cell, connecting the cell surface to the nucleus via transmembrane protein complexes in the plasma and nuclear membranes. It transmits extracellular forces to the cell interior, providing mechanical cues that influence cellular decisions, but also actively generates...review 2022
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Muntz, I.A.A. (author), Fenu, M. (author), van Osch, G.J.V.M. (author), Koenderink, G.H. (author)Living tissue is able to withstand large stresses in everyday life, yet it also actively adapts to dynamic loads. This remarkable mechanical behaviour emerges from the interplay between living cells and their non-living extracellular environment. Here we review recent insights into the biophysical mechanisms involved in the reciprocal...review 2022
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Castillo Ransanz, LucĂa (author), van Altena, P.F.J. (author), Heine, Vivi M. (author), Accardo, A. (author)The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and...review 2022
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Boot, R.C. (author), Koenderink, G.H. (author), Boukany, P. (author)Spheroids are widely used in vitro 3D multicellular model systems that mimic complex physiological microenvironments of tissues. As different cell types vary in deformability and adhesion, the choice of (heterogeneous) cell composition will define overall spheroid mechanics, including their viscoelasticity and effective surface tension. These...review 2021