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Knol, Maria J. (author), Heshmatollah, Alis (author), Cremers, Lotte G.M. (author), Ikram, M. Kamran (author), Uitterlinden, André G. (author), van Duijn, Cornelia M. (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author), Adams, Hieab H.H. (author)
Cognition in adults shows variation due to developmental and degenerative components. A recent genomewide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to...
journal article 2019
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Leeuwis, Anna E. (author), Hooghiemstra, Astrid M. (author), Amier, Raquel (author), Ferro, Doeschka A. (author), Franken, Leonie (author), Nijveldt, Robin (author), Kuijer, Joost P A (author), Bronzwaer, Anne Sophie G T (author), van Lieshout, Johannes J. (author), Rietberg, Marc B. (author), Veerbeek, Janne M. (author), Huijsmans, Rosalie J. (author), Backx, Frank J G (author), Teunissen, Charlotte E. (author), Bron, Esther E. (author), Barkhof, Frederik (author), Prins, Niels D. (author), Shahzad, Rahil (author), Niessen, W.J. (author), de Roos, Albert (author), van Osch, Matthias J P (author), van Rossum, Albert C. (author), Biessels, Geert J. (author), van der Flier, Wiesje M. (author)
There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80...
journal article 2017
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Cremers, LGM (author), de Groot, M (author), Hofman, A (author), Krestin, GP (author), van der Lugt, A. (author), Niessen, W.J. (author), Vernooij, MW (author), Arfan Ikram, M. (author)
White matter microstructural integrity has been related to cognition. Yet, the potential role of specificwhite matter tracts on top of a global white matter effect remains unclear, especially when consideringspecific cognitive domains. Therefore, we determined the tract-specific effect of white matter micro-structure on global cognition and...
journal article 2016