document

Combining Genomic Biomarkers to Guide Immunotherapy in Non-Small Cell Lung Cancer

van de Haar, Joris (author), Mankor, Joanne M. (author), Hummelink, Karlijn (author), Monkhorst, Kim (author), Smit, Egbert F. (author), Wessels, L.F.A. (author), Cuppen, Edwin (author), Aerts, Joachim G.J.V. (author), Voest, Emile E. (author)

PURPOSE: The clinical value of STK11, KEAP1, and EGFR alterations for guiding immune checkpoint blockade (ICB) therapy in non-small cell lung cancer (NSCLC) remains controversial, as some patients with these proposed resistance biomarkers show durable ICB responses. More specific combinatorial biomarker approaches are urgently needed for this...

journal article 2024

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Understanding cross-sectoral innovations for urban water management through the lens of organizational ambidexterity

Nieuwenhuis, E.M. (author), de Bruijn, J.A. (author), Cuppen, Eefje (author), Langeveld, J.G. (author)

Urban water systems worldwide need integrated, cross-sectoral innovations to anticipate developments like climate change and population growth. Development and implementation of such innovations is challenging due to the operational and sectoral mindset of organizations in which these innovations take place. This study uses the concept of...

journal article 2023

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From expectational conflicts to energy synergies: The evolution of societal value co-creation in energy hub development

Rodhouse, T.S.G.H. (author), Cuppen, E. H.W.J. (author), Pesch, U. (author), Correljé, A. (author)

Societal value co-creation is an emerging practice in renewable energy projects. Despite its increasing popularity, however, unclarities persist regarding its operationalisation. This paper provides relevant insights by explaining how expectations of societal value co-creation evolved and became performed in a co-creative energy hub project in...

journal article 2023

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Contentious governance of wind energy planning: strategic dilemmas in collaborative resistance by local governments and citizen action groups

Verhoeven, Imrat (author), Spruit, Shannon (author), van de Grift, E.M.H.R. (author), Cuppen, Eefje (author)

Local governments are at the heart of implementing increasingly ambitious national plans for wind energy. While support by local governments for these plans has been studied extensively, only few studies have looked into local governments’ contestation of wind energy development. In this paper we analyze contentious governance processes in which...

journal article 2022

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Functional diversity in circular building projects: A novel perspective to study actors, roles and circular results

van Staveren, D. (author), Cuppen, Eefje (author), Heurkens, E.W.T.M. (author), Vos, Marije (author)

Construction sectors have a long way to go to realize a circular economy. Many organizational barriers and institutional characteristics inhibit the sector’s transition to circular practices. Nevertheless, within this early phase of the transition, several building projects were realized. This research aims to learn from these frontrunners, in...

conference paper 2022

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Thermal Desorption of Interstellar Ices: A Review on the Controlling Parameters and Their Implications from Snowlines to Chemical Complexity

Minissale, Marco (author), Aikawa, Yuri (author), Bergin, Edwin (author), Bertin, Mathieu (author), Brown, Wendy A. (author), Cazaux, S.M. (author), Charnley, Steven B. (author), Coutens, Audrey (author), Cuppen, Herma M. (author)

The evolution of star-forming regions and their thermal balance are strongly influenced by their chemical composition, which, in turn, is determined by the physicochemical processes that govern the transition between the gas phase and the solid state, specifically icy dust grains (e.g., particle adsorption and desorption). Gas-grain and grain...

review 2022

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Understanding Value Change in the Energy Transition: Exploring the Perspective of Original Institutional Economics

Correljé, A. (author), Pesch, U. (author), Cuppen, Eefje (author)

In this paper, we take inspiration from original institutional economics (OIE) as an approach to study value change within the highly complex assembly of sociotechnical transformations that make up the energy transition. OIE is examined here as a suitable perspective, as it combines Dewey’s pragmatist philosophy and a methodological...

journal article 2022

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The role of integration for future urban water systems: Identifying Dutch urban water practitioners' perspectives using Q methodology

Nieuwenhuis, E.M. (author), Cuppen, Eefje (author), Langeveld, J.G. (author)

Urban water systems are under increased pressure from ongoing developments like climate change, population growth and urbanization. While it is clear that current urban water challenges need a more integrated approach, practitioners disagree on what such an integrated approach means exactly. Integration could therefore be described as a...

journal article 2022

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Towards the integrated management of urban water systems: Conceptualizing integration and its uncertainties

Nieuwenhuis, E.M. (author), Cuppen, Eefje (author), Langeveld, J.G. (author), de Bruijn, J.A. (author)

Climate change and urbanization, as well as growing environmental and economic concerns, highlight the limitations of traditional wastewater practices and thereby challenge the management of urban water systems. Both in theory and in practice, it has been widely acknowledged that the challenges of the twenty-first century require solutions...

journal article 2021

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Public agency and responsibility in energy governance: A Q study on diverse imagined publics in the Dutch heat transition

Rodhouse, T.S.G.H. (author), Pesch, U. (author), Cuppen, E. H.W.J. (author), Correljé, A. (author)

In Energy Social Science (ESS), the concept of imagined publics is used to describe how energy actors perceive societal groups around new energy technologies and projects. Findings indicate that imagined publics often build upon deficit assumptions; people are (unjustly) considered unknowledgeable, incapable, unwilling and irresponsible...

journal article 2021

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When controversies cascade: Analysing the dynamics of public engagement and conflict in the Netherlands and Switzerland through “controversy spillover”

Cuppen, Eefje (author), Ejderyan, Olivier (author), Pesch, U. (author), Spruit, S. (author), van de Grift, E.M.H.R. (author), Correljé, A. (author), Taebi, B. (author)

Energy controversies have been widely studied. Such studies are, however, generally based on either single case studies, providing rich and in-depth understanding of (local) dynamics of planning and implementation processes, or they focus on understanding responses to a specific technology (not bound to a location). Therefore these studies...

journal article 2020

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Co-creation, control or compliance? How Dutch community engagement professionals view their work

van de Grift, E.M.H.R. (author), Cuppen, E.H.W.J. (author), Spruit, S. (author)

Most literature on community engagement (CE) focuses on why and how local communities respond to energy projects or technologies. There has been very limited attention to project developers and the way they shape CE in the literature. We address this gap by focusing on the work of professionals active within or for energy companies, who are...

journal article 2020

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Exploring incumbents’ agency: Institutional work by grid operators in decentralized energy innovations

Galeano Galvan, M.J. (author), Cuppen, E.H.W.J. (author), Taanman, Mattijs (author)

The agency of incumbents has gained increasing attention in the study of transitions. Recent studies show that besides being inert and resistant to change, incumbents can also support transitions. We focus on the agency of a particular type of incumbent, grid operators. In several countries, these actors play an active role in institutional...

journal article 2020

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Participatory multi-modelling as the creation of a boundary object ecology: the case of future energy infrastructures in the Rotterdam Port Industrial Cluster

Cuppen, E.H.W.J. (author), Nikolic, I. (author), Kwakkel, J.H. (author), Quist, J.N. (author)

Finding leverage points for sustainability transformation of industrial and infrastructure systems is challenging, given that transformation is emergent from the complex interactions among socio-technical system elements over time within a specific social, technical and geographical context. Participatory multi-modelling, in which modellers...

journal article 2020

document

Eindrapportage Project Windmaster: De weg naar een adaptief investeringsbeleid

Wurth, Ton (author), Nikolic, I. (author), Kwakkel, J.H. (author), Sloot, Maarten (author), Cuppen, E.H.W.J. (author), Quist, J.N. (author)

Nederland is op weg naar een CO2-neutrale samenleving in 2050. Zo ook het haven industrieel cluster van Rotterdam (HIC). Om dat te bereiken zal de energievoorziening de komende jaren moeten veranderen. Deze verandering heeft een grote impact op de energieinfrastructuur. In het Windmaster project wordt gefocust op de huidige aardgas-,H2- en...

report 2019

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Spillover dynamics in energy controversies

Cuppen, E.H.W.J. (author), Pesch, U. (author), Spruit, S. (author), Correljé, A. (author), van de Grift, E.M.H.R. (author), Taebi, B. (author)

poster 2019

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De toekomst van het stedelijk watersysteem: Opereren in een stad vol transities

Nieuwenhuis, E.M. (author), Cuppen, E.H.W.J. (author), Langeveld, J.G. (author), de Bruijn, J.A. (author)

Gedreven door ontwikkelingen zoals klimaatverandering, verstedelijking en digitalisering zien we in het stedelijk watersysteem steeds vaker oplossingen ‘buiten de buis’. Oplossingen zoals publieke pleinen met een waterbergende functie, polderdaken met een dynamische waterberging, zwembaden verwarmd met warmte uit (afval)water; het zijn allemaal...

journal article 2019

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Industrial Symbiosis: Towards a design process for eco-industrial clusters by integrating Circular Economy and Industrial Ecology perspectives

Baldassarre, B.R. (author), Schepers, Micky (author), Bocken, N.M.P. (author), Cuppen, E.H.W.J. (author), Korevaar, G. (author), Calabretta, G. (author)

Industrial Symbiosis (IS) is a collective approach to competitive advantage in which separate industries create a cooperative network to exchange materials, energy, water and/or by-products. By addressing issues related to resource depletion, waste management and pollution, IS plays an important role in the transition towards sustainable...

journal article 2019

document

Governing crowd-based innovations: an interdisciplinary research agenda

Cuppen, E.H.W.J. (author), Klievink, A.J. (author), Doorn, N. (author)

The crowd increasingly plays a key role in facilitating innovations in a variety of sectors, spurred on by IT-developments and the concomitant increase in connectivity. Initiatives in this direction, captured under the umbrella-term ‘crowd-based innovations’ (CBI), offer novel opportunities in all domains of society by increasing the access,...

journal article 2019

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When innovation meets institutions: the challenges of crowd-based innovations for governance

Galeano Galvan, M.J. (author), Cuppen, E.H.W.J. (author), Klievink, A.J. (author)

poster 2018