Intercept and Inject: DNS Response Manipulation in the Wild

DNS is a protocol responsible for translating human-readable domain names into IP addresses. Despite being essential for many Internet services to work properly, it is inherently vulnerable to manipulation. In November 2021, users from Mexico received bogus DNS responses when resolving whatsapp.net. It appeared that a BGP route leak diverged DNS...

Air quality impacts of COVID-19 lockdown measures detected from space using high spatial resolution observations of multiple trace gases from Sentinel-5P/TROPOMI

The aim of this paper is to highlight how TROPOspheric Monitoring Instrument (TROPOMI) trace gas data can best be used and interpreted to understand event-based impacts on air quality from regional to city scales around the globe. For this study, we present the observed changes in the atmospheric column amounts of five trace gases (NO2, SO2,...

Biomass burning combustion efficiency observed from space using measurements of CO and NO2 by the TROPOspheric Monitoring Instrument (TROPOMI)

The global fire emission inventories depend on ground and airborne measurements of species-specific emission factors (EFs), which translate dry matter losses due to fires to actual trace gas and aerosol emissions. The EFs of nitrogen oxides (NOx) and carbon monoxide (CO) can function as a proxy for combustion efficiency to distinguish flaming...

Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations

In this study, we analyzed turbulent flows through a phantom (a 180^∘ bend with narrowing) at peak systole and a patient-specific coarctation of the aorta (CoA), with a pulsating flow, using magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). For MRI, a 4D-flow MRI is performed using a 3T scanner. For CFD, the...

Towards a traffic map of the Internet Connecting the dots between popular services and users: Connecting the dots between popular services and users

The impact of Internet phenomena depends on how they impact users, but researchers lack visibility into how to translate Internet events into their impact. Distressingly, the research community seems to have lost hope of obtaining this information without relying on privileged viewpoints. We argue for optimism thanks to new network...

Predicting drug (combination) response through data integration: The whole is greater than the sum of its parts

In order to improve anti-cancer treatment, we need to better understand why some patients respond to a given anti-cancer treatment, while others do not. To this end, several large-scale drug response screens have been performed in recent years, in which hundreds of tumor cell lines have been characterized formany molecular features (e.g....

S5P/TROPOMI: The first year in orbit

On 13 October 2017 the European Sentinel 5 Precursor was successfully launched, with on board the TROPOMI (TROPOspheric Monitoring Instrument). TROPOMI is an imaging spectrometer developed by The Netherlands and ESA for monitoring the atmospheric composition, for air quality climate and ozone layer monitoring. The launch of TROPOMI marks the...

iTOP: Inferring the topology of omics data

Motivation In biology, we are often faced with multiple datasets recorded on the same set of objects, such as multi-omics and phenotypic data of the same tumors. These datasets are typically not independent from each other. For example, methylation may influence gene expression, which may, in turn, influence drug response. Such relationships...

Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells

Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of somatic genomic variants. The robust...

High-resolution tropospheric carbon monoxide profiles retrieved from CrIS and TROPOMI

The Measurements of Pollution in the Troposphere (MOPITT) instrument is the only satellite-borne sensor in operation that uses both thermal (TIR) and nearinfrared (NIR) channels to estimate CO profiles. With more than 15 years (2000 to present) of validated multispectral observations, MOPITT provides the unique capability to separate CO in...

TANDEM: A two-stage approach to maximize interpretability of drug response models based on multiple molecular data types

Motivation: Clinical response to anti-cancer drugs varies between patients. A large portion of this variation can be explained by differences in molecular features, such as mutation status, copy number alterations, methylation and gene expression profiles. We show that the classic approach for combining these molecular features (Elastic Net...

A Landscape of Pharmacogenomic Interactions in Cancer

Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, we report how cancerdriven alterations identified in 11,289 tumors from 29 tissues (integrating somatic mutations, copy...

A Biocatalytic Aza-Achmatowicz Reaction

A catalytic, enzyme-initiated (aza-) Achmatowicz reaction is presented. The involvement of a robust vanadium-dependent peroxidase from Curvularia inaequalis allows the simple use of H₂O₂ and catalytic amounts of bromide.

Influence of the accuracy of angiography-based reconstructions on velocity and wall shear stress computations in coronary bifurcations: A phantom study

Wall shear stress (WSS) plays a key role in the onset and progression of atherosclerosis in human coronary arteries. Especially sites with low and oscillating WSS near bifurcations have a higher propensity to develop atherosclerosis. WSS computations in coronary bifurcations can be performed in angiography-based 3D reconstructions. It is...

Landscape Architecture at TU Delft 1973-2011: Ter gelegenheid afscheid Prof. Dr. Clemens Steenbergen

Het is haast onmogelijk om de werkzame jaren van Prof. Dr. Clemens Steenbergen hier op de TU Delft in het kort samen te vatten. Dit is een persoonlijk boek van collega's, medewerkers en studenten ter gelegenheid van zijn afscheid op 15. December 2011.

Buiten Plaats: City-escape

Metamorfosen: Beeldtypen van architectuur en landschap

Het landschapstheater omvat een veel grotere rijkdom aan decors, zetstukken en requisieten, dan er in een catalogus valt te etaleren. Toch hebben wij geprobeerd in deze eerste voorlopige versie van het boekje om een aantal van zulke beeldtypen te documenteren en de grenzen ervan af te tasten. Voor de voorbeelden hebben wij vrij geput uit onze...