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de Boer, Bas (author), Kudina, O. (author)In this paper, we examine the qualitative moral impact of machine learning-based clinical decision support systems in the process of medical diagnosis. To date, discussions about machine learning in this context have focused on problems that can be measured and assessed quantitatively, such as by estimating the extent of potential harm or...journal article 2022
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van Wesenbeeck, B (author), Wolters, Guido (author), Antolínez, José A. Á. (author), Kalloe, S.A. (author), Hofland, Bas (author), de Boer, W.P. (author), Çete, Ceylan (author), Bouma, Tjeerd J. (author)Worldwide, communities are facing increasing flood risk, due to more frequent and intense hazards and rising exposure through more people living along coastlines and in flood plains. Nature-based Solutions (NbS), such as mangroves, and riparian forests, offer huge potential for adaptation and risk reduction. The capacity of trees and forests...journal article 2022
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Nuijens, Louise (author), Savazzi, A.C.M. (author), de Boer, G. (author), Brilouet, P. E. (author), George, G. (author), Lothon, M. (author), Zhang, D. (author)Profiles of eddy momentum flux divergence are calculated as the residual in the momentum budget constructed from airborne circular dropsonde arrays ((Formula presented.) 220 km) for 13 days during the EUREC (Formula presented.) A/ATOMIC field campaign. The observed dynamical forcing averaged over all flights agrees broadly with European...journal article 2022
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Kudina, O. (author), de Boer, Bas (author)Rationale: This paper aims to show how the focus on eradicating bias from Machine Learning decision-support systems in medical diagnosis diverts attention from the hermeneutic nature of medical decision-making and the productive role of bias. We want to show how an introduction of Machine Learning systems alters the diagnostic process....journal article 2021
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Maduro, L.A. (author), de Boer, Charles (author), Zuiddam, M.R. (author), Memisevic, E. (author), Conesa Boj, S. (author)We report on the fabrication of molybdenum (Mo) nanopillar (NP) arrays with NP diameters down to 75 nm by means of deep-reactive ion etching at cryogenic temperatures. A variable-thickness Mo metal layer sputtered onto a Si<sub>3</sub>N<sub>4</sub>/Si substrate makes possible NPs with different lengths in a controllable manner. We demonstrate...journal article 2021
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Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidancede Boer, Lisanne L. (author), Kho, Esther (author), Van de Vijver, Koen K. (author), Vranken Peeters, Marie Jeanne T.F.D. (author), van Duijnhoven, Frederieke (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)Background: Although the incidence of positive resection margins in breast-conserving surgery has decreased, both incomplete resection and unnecessary large resections still occur. This is especially the case in the surgical treatment of ductal carcinoma in situ (DCIS). Diffuse reflectance spectroscopy (DRS), an optical technology based on...journal article 2021
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Buijsrogge, A. (author), de Boer, Pieter-Tjerk (author), Scheinhardt, Werner R.W. (author)We consider importance sampling simulation for estimating the probability of reaching large total number of customers in an (Formula presented.) tandem queue, during a busy cycle of the system. Our main result is a procedure for obtaining a family of asymptotically efficient changes of measure based on subsolutions. We explicitly show these...journal article 2021
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Van Delft, Falco C.M.J.M. (author), Sudalaiyadum Perumal, Ayyappasamy (author), van Langen-Suurling, A.K. (author), de Boer, C.R. (author), Kašpar, Ondřej (author), Tokárová, Viola (author), Dirne, F. (author), Nicolau, Dan V. (author)Non-deterministic polynomial (NP-) complete problems, whose number of possible solutions grows exponentially with the number of variables, require by necessity massively parallel computation. Because sequential computers, such as solid state-based ones, can solve only small instances of these problems within a reasonable time frame, parallel...journal article 2021
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Srinivasa Raja, A. (author), de Boer, Pascal (author), Giepmans, Ben N.G. (author), Hoogenboom, J.P. (author)Electron microscopy is crucial for imaging biological ultrastructure at nanometer resolution. However, electron irradiation also causes specimen damage, reflected in structural and chemical changes that can give rise to alternative signals. Here, luminescence induced by electron-beam irradiation is reported across a range of materials widely...journal article 2021
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de Boer, Bas (author), Lemke, M. (author)Obesity has been pointed out as one of the main current health risks leading to calls for a so-called “war on obesity”. As we show in this paper, activities that attempt to counter obesity by persuading people to adjust a specific behavior often employ a pedagogy of regret and disgust. Nowadays, however, public healthcare campaigns that aim to...journal article 2021
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Yang, Y. (author), de Boer, Ane (author), den Uijl, J.A. (author)A recent contest of shear tests modelling was carried out in 2019. Teams from universities and consultancies around Europe were invited to predict the shear capacity of two reinforced concrete beams. The basics of the numerical models were to be set up according the Dutch NLFEM Guideline RTD 1016–1:2017. In the contest, two reinforced...journal article 2021
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Wiegel, M.F. (author), de Boer, W.P. (author), van Koningsveld, M. (author), van der Hout, A.J. (author), Reniers, A.J.H.M. (author)Seaport operability is key to the economic viability of ports. Metocean conditions (e.g., wind, short waves, and infragravity waves) affect this operability when certain thresholds are exceeded. This paper describes a method for the global mapping of seaport operability risk indicators using open-source metocean data. This global-scale...journal article 2021
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Geelhoed, W. J. (author), Damanik, F. F.R. (author), Hamming, J. F. (author), van Agen, M. S. (author), de Boer, H. C. (author), Restrepo, M. Tobón (author), Kislaya, A. (author), Poelma, C. (author), van Zonneveld, A. J. (author)The durability of prosthetic arteriovenous (AV) grafts for hemodialysis access is low, predominantly due to stenotic lesions in the venous outflow tract and infectious complications. Tissue engineered blood vessels (TEBVs) might offer a tailor-made autologous alternative for prosthetic grafts. We have designed a method in which TEBVs are...journal article 2020
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de Boer, W.P. (author), Mao, Yongjing (author), Hagenaars, Gerben (author), de Vries, S. (author), Slinger, J (author), Vellinga, T. (author)In Africa, several new seaport developments are being considered. In sedimentary environments, such port developments can have adverse impacts on the evolution of adjacent coastlines. To learn from past port engineering practice, we created a unique database containing the coastline evolution and characteristics of 130 existing African seaports....journal article 2019
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Lantsoght, E.O.L. (author), Yang, Y. (author), van der Veen, C. (author), Hordijk, D.A. (author), de Boer, A (author)Existing bridges with large uncertainties can be assessed with a proof load test. In a proof load test, a load representative of the factored live load is applied to the bridge at the critical position. If the bridge can carry this load without distress, the proof load test shows experimentally that the bridge fulfills the requirements of the...journal article 2019
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Performance evaluation of wave input reduction techniques for modeling inter-annual sandbar dynamicsde Queiroz, Bruna (author), Scheel, F. (author), Caires, Sofia (author), Walstra, D.J.R. (author), Olij, Derrick (author), Yoo, Jeseon (author), Reniers, A.J.H.M. (author), de Boer, W.P. (author)In process-based numerical models, reducing the amount of input parameters, known as input reduction (IR), is often required to reduce the computational effort of these models and to enable long-term, ensemble predictions. Currently, a comprehensive performance assessment of IR-methods is lacking, which hampers guidance on selecting suitable...journal article 2019
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Burek, Bastien O. (author), de Boer, Sabrina R. (author), Tieves, F. (author), Zhang, W. (author), van Schie, M.M.C.H. (author), Bormann, Sebastian (author), Alcalde, Miguel (author), Holtmann, Dirk (author), Hollmann, F. (author)Photoenzymatic cascades can be used for selective oxygenation of C−H-Bonds under mild conditions circumventing the hydrogen peroxide mediated peroxygenase inactivation via in situ H<sub>2</sub>O<sub>2</sub> generation. Here, we report the “on demand” production of hydrogen peroxide via methanol assisted reduction of molecular oxygen using UV...journal article 2019
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Xu, Yanjie (author), Si, Yali (author), Takekawa, John (author), Liu, Q. (author), Prins, Herbert H. T. (author), Yin, Shenglai (author), Prosser, Diann J. (author), Gong, Peng (author), de Boer, Willem F. (author)Habitat loss can trigger migration network collapse by isolating migratory bird breeding grounds from nonbreeding grounds. Theoretically, habitat loss can have vastly different impacts depending on the site's importance within the migratory corridor. However, migration‐network connectivity and the impacts of site loss are not completely...journal article 2019
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de Boer, W.P. (author), Slinger, J (author), wa Kangeri, Arno K. (author), Vreugdenhil, H.S.I. (author), Taneja, P. (author), Addo, Kwasi Appeaning (author), Vellinga, T. (author)Long-term sustainable port development requires accounting for the intrinsic values of ecosystems. However, in practice, ecosystem considerations often only enter the planning and design process of ports when required by an Environmental Impact Assessment. At this late stage, most of the design is already fixed and opportunities to minimize...journal article 2019
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Zhang, W. (author), Ma, M. (author), Huijbers, M.M.E. (author), Filonenko, G.A. (author), Pidko, E.A. (author), van Schie, M.M.C.H. (author), de Boer, Sabrina (author), Smith, W.A. (author), Hollmann, F. (author)A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the...journal article 2019