- document
-
Tepeli, Y.I. (author), Seale, C.F. (author), P. Gonçalves, Joana (author)Motivation<br/><br/>Anti-cancer therapies based on synthetic lethality (SL) exploit tumour vulnerabilities for treatment with reduced side effects, by targeting a gene that is jointly essential with another whose function is lost. Computational prediction is key to expedite SL screening, yet existing methods are vulnerable to prevalent selection...journal article 2023