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Plat, Benthe (author)This report delves into the challenging process of translating complex tests from the Child Brain Lab into a design that is both accessible and engaging for children. The Child Brain Lab, part of the Erasmus MC Sophia Children’s Hospital, conducts research on brain development to gain a better understanding of the course of brain disorders and...master thesis 2023
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Habets, Philippe C. (author), Kalafatakis, Konstantinos (author), Dzyubachyk, O. (author), van der Werff, Steven J.A. (author), Keo, D.L. (author), Thakrar, Jamini (author), Mahfouz, A.M.E.T.A. (author), Pereira, Alberto M. (author), Russell, Georgina M. (author)The characteristic endogenous circadian rhythm of plasma glucocorticoid concentrations is made up from an underlying ultradian pulsatile secretory pattern. Recent evidence has indicated that this ultradian cortisol pulsatility is crucial for normal emotional response in man. In this study, we investigate the anatomical transcriptional and...journal article 2023
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Shenoy, Rohan (author)This Master's thesis project is conceived in two parts. <br/><br/>The first part is the research project and is titled <<The Art of Acquiring Flow>> where the study assesses an architect’s ability to experience ‘design flow’, during the ideation phase, based on the type of design tool utilized. In order to test the hypothesis, I...master thesis 2022
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Nunez-Gonzalez, L. (author), Nagtegaal, M.A. (author), Poot, D.H.J. (author), de Bresser, J. (author), van Osch, M. J.P. (author), Hernandez-Tamames, J.A. (author), Vos, F.M. (author)MR fingerprinting (MRF) is a promising method for quantitative characterization of tissues. Often, voxel-wise measurements are made, assuming a single tissue-type per voxel. Alternatively, the Sparsity Promoting Iterative Joint Non-negative least squares Multi-Component MRF method (SPIJN-MRF) facilitates tissue parameter estimation for...journal article 2022
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Robben, Stijn (author)Predicting the effects of drugs before human clinical trails is at the heart of drug discovery and screening processes. To overcome limitations of conventional models used in pre-clinical research stages, advancements in fabrication, microfluidics, tissue engineering and sensor development allow for platforms that ever more closely emulate human...master thesis 2021
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Lusse, Bryan (author)Long acquisition times impede the routine clinical use of quantitative magnetic resonance imaging (qMRI). qMRI quantifies meaningful tissue parameters in T1-, T2-, and PD-maps, as opposed to conventional (qualitative) weighted MRI (wMRI), which only visualises contrast between tissues. Although methods exist that generate synthetic wMRI from...master thesis 2021
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van der Molen, Dana (author)Glioblastoma multiforme tumors (GBM) are the most frequent and aggressive brain tumor type and have a very low survival rate. In order to improve the patient’s outcome for a patient suffering from GBM the production of brain phantoms can be of great help. A brain phantom can be used for multiple purposes, such as neurological planning, training...master thesis 2021
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Radman, A. (author), Kousoulas, Stavros (author), Djebbara, Z. (author), K., August (author)The philosophies of substance presuppose a subject which then encounters a datum. This subject then reacts to the datum. The process ontology presupposes a datum (firstness) which is met with feelings (secondness), and progressively attains the unity of a subject (thirdness). It is in this sense that our bodily experience is primarily an...conference paper 2020
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Dubost, Florian (author), Adams, Hieab (author), Yilmaz, Pinar (author), Bortsova, Gerda (author), Tulder, Gijs van (author), Ikram, M. Arfan (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Bruijne, Marleen de (author)Finding automatically multiple lesions in large images is a common problem in medical image analysis. Solving this problem can be challenging if, during optimization, the automated method cannot access information about the location of the lesions nor is given single examples of the lesions. We propose a new weakly supervised detection method...journal article 2020
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Taskin, U. (author), Solberg Eikrem, Kjersti (author), Naevdal, Geir (author), Jakobsen, Morten (author), Verschuur, D.J. (author), van Dongen, K.W.A. (author)Transcranial ultrasound has been used to image the brain since 1942. Currently, it is regaining interest and full-waveform inversion (FWI) methods are now employed to reconstruct speed-of-sound profiles of the brain. Many of these methods require a good starting model. Here, we test the applicability of contrast source inversion (CSI) as a...conference paper 2020
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Ozsahin, Ilker (author), Chen, Ling (author), Könik, Arda (author), King, Michael A. (author), Beekman, F.J. (author), Mok, Greta S.P. (author)Single photon emission computed tomography (SPECT) is an important imaging modality for various applications in nuclear medicine. The use of multi-pinhole (MPH) collimators can provide superior resolution-sensitivity trade-off when imaging small field-of-view compared to conventional parallel-hole and fan-beam collimators. Besides the very...review 2020
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Pourquié, Valérie (author)Human brain research is advancing, facilitated by improved high-throughput techniques and systematically preservation of brain tissue in brain banks. Due to the complex organization and regulation of the brain, most studies only focus on a single aspect of healthy and diseased samples. This research integrates analyses of the transcriptome and...master thesis 2019
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Kor, Flip (author)Neurosurgery is technically challenging because of the inaccessibility and sensitivity of the brain. The risk of complications for the patient is high and simulation-based training is therefore preferred. However, surgical training in cadavers and virtual reality is not satisfactory. A phantom is a model of organs or tissues consisting of tissue...master thesis 2019
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Dik, Emilie (author)Brain, outside the body, will decay quickly, causing ex vivo studies to be difficult. Having a phantom model has a great beneficial value for numerous reasons. Phantoms are, among others, used in research centres, to validate new equipment, to develop biomechanical models or to test new treatment methods. They are representations of organs or...master thesis 2019
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Wang, Johnny (author)The gap between predicted brain age and chronological age could serve as biomarker for early-stage neurodegeneration and as potentially as a risk indicator for dementia. We assess the utility of this age gap as a risk biomarker for incident dementia in a general elderly population. The brain age is estimated from longitudinal brain magnetic...master thesis 2019
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Arkesteijn, G.A.M. (author)The brain’s white matter mainly consists of (myelinated) axons that connect different parts of the brain. Diffusion-weighted MRI (DW-MRI) is a technique that is particularly suited to image this white matter. The MRI signal in DW-MRI is sensitized to diffusion of water in the microstructure by introducing strong bipolar gradients in the MRI...doctoral thesis 2018
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Filatova, O.G. (author), van Vliet, L.J. (author), Schouten, A.C. (author), Kwakkel, Gert (author), van der Helm, F.C.T. (author), Vos, F.M. (author)Better insight into white matter (WM) alterations after stroke onset could help to understand the underlying recovery mechanisms and improve future interventions. MR diffusion imaging enables to assess such changes. Our goal was to investigate the relation of WM diffusion characteristics derived from diffusion models of increasing complexity...journal article 2018
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Mahinrad, Simin (author), Bulk, Marjolein (author), Van Der Velpen, Isabelle (author), Mahfouz, A.M.E.T.A. (author), Van Roon-Mom, Willeke (author), Fedarko, Neal (author), Yasar, Sevil (author), Sabayan, Behnam (author), Van Heemst, Diana (author), Van Der Weerd, Louise (author)Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aimed to: (1) map the gene expression and localization of NP and their receptors (NPR) in human...journal article 2018
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), De Jong, Sebastiaan (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)In this data report we make available to the community a highly variable longitudinal MRI mouse brain data set of ischemic lesion after transient middle cerebral artery occlusion (tMCAo). Together with the provided semi-automated and automated segmentations, these data can be used to further improve the method proposed by Mulder et al. (2017)...journal article 2017
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Stijntjes, M. (author), De Craen, Anton J M (author), Van Der Grond, Jeroen (author), Meskers, Carel G M (author), Slagboom, P. Eline (author), Maier, Andrea B. (author)Background: The positive relationship between cognitive and physical performance has been widely established. The influence of brain structure on both domains has been shown as well. Objective: We studied whether the relationship between brain structure and physical performance is independent of cognitive performance. Methods: This was a...journal article 2016
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