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Tesi, N. (author), van der Lee, S.J. (author), Hulsman, M. (author), Jansen, Iris E. (author), Stringa, N. (author), van Schoor, N.M. (author), Huisman, Martijn (author), Reinders, M.J.T. (author), Holstege, H. (author)Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate the functions of longevity-associated variants. Using a cohort of centenarians with...journal article 2021
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Huisman, K.H. (author), Thijssen, J.M. (author)One of the manifestations of chirality-induced spin selectivity is the magnetoresistance (MR) in two-terminal transport measurements on molecular junctions. This paper investigates the effect of spin-orbit coupling in the leads on the polarization of the transmission. A helicene molecule between two gold contacts is studied using a tight...journal article 2021
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Genetics Contributes to Concomitant Pathology and Clinical Presentation in Dementia with Lewy Bodiesvan der Lee, S.J. (author), van Steenoven, Inger (author), van de Beek, Marleen (author), Tesi, N. (author), Jansen, Iris E. (author), van Schoor, N.M. (author), Reinders, M.J.T. (author), Huisman, Martijn (author), Scheltens, Philip (author)Background: Dementia with Lewy bodies (DLB) is a complex, progressive neurodegenerative disease with considerable phenotypic, pathological, and genetic heterogeneity. Objective: We tested if genetic variants in part explain the heterogeneity in DLB. Methods: We tested the effects of variants previously associated with DLB (near APOE, GBA, and...journal article 2021
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Reus, Lianne M. (author), Jansen, Iris E. (author), van Rooij, Jeroen (author), van Schoor, Natasja M. (author), Tesi, N. (author), Reinders, M.J.T. (author), Huisman, M.A. (author), van der Lugt, Aad (author), van der Lee, Sven J. (author)Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD cannot be genetically explained yet and it is likely that there are still FTD risk loci to be discovered. Common variants have been identified with genome-wide association studies (GWAS), but these studies have not systematically searched for rare variants...journal article 2021
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Jewitt, Carey (author), Price, Sara (author), Steimle, Jürgen (author), Huisman, G. (author), Golmohammadi, Lili (author), Pourjafarian, Narges (author), Frier, William (author), Howard, Thomas (author), Ipakchian Askari, Sima (author)This qualitative exploratory research paper presents a Manifesto for Digital Social Touch in Crisis - a provocative call to action to designers, developers and researchers to rethink and reimagine social touch through a deeper engagement with the social and sensory aspects of touch. This call is motivated by concerns that social touch is in a...journal article 2021
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van Kessel, L.C.P.M. (author), Huisman, T.A. (author), Hagen, Cornelis W. (author)Background: Line-edge roughness (LER) is often measured from top-down critical dimension scanning electron microscope (CD-SEM) images. The true three-dimensional roughness profile of the sidewall is typically ignored in such analyses. Aim: We study the response of a CD-SEM to sidewall roughness (SWR) by simulation. Approach: We generate...journal article 2020
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Huisman, Luc Hans (author), Bando, Roberto (author), Clark, Kate (author), Coenen, Thijs (author), Frijhof, Willem (author), Meijvogel-de Koning, P.M. (author), Ngan-Tillard, D.J.M. (author), Opdebeeck, Johan (author)Een dwarsfluit uit het begin van de zestiende eeuw. Die doken archeologen op uit een scheepswrak in het Markermeer. Alleen dat al is een extreem zeldzame gebeurtenis. Maar van wie kan die fluit geweest zijn? Een stuk papier bij het mondgat zet een gevarieerd team van deskundigen op een spoor dat warmer en warmer wordtjournal article 2020
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Huisman, D. J. (author), Bach, A. (author), Ngan-Tillard, D.J.M. (author), Joosten, I. (author), van den Eynde, G. (author)We investigated the characteristics of a group of 13 Middle Iron Age egg-shaped crucibles and crucible fragments from Tilburg (The Netherlands). We used a combination of optical and chemical analyses, including hand-held XRF, microCT scanning and 3-D printing polarizing light microscopy and SEM-EDX. The chemical analyses confirmed that the...journal article 2020
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Roelvink, D. (author), Huisman, B.J.A. (author), Elghandour, A.M.M.A. (author), Ghonim, Mohamed (author), Reyns, J.A.H. (author)With large-scale human interventions and climate change unfolding as they are now, coastal changes at decadal timescales are not limited to incremental modifications of systems that are fixed in their general geometry, but often show significant changes in layout that may be catastrophic for populations living in previously safe areas. This...journal article 2020
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Tesi, N. (author), van der Lee, S.J. (author), Hulsman, M. (author), Jansen, Iris E. (author), Stringa, N. (author), van Schoor, N.M. (author), Scheltens, Philip (author), van der Flier, Wiesje M. (author), Huisman, Martijn (author), Reinders, M.J.T. (author), Holstege, H. (author)Developing Alzheimer’s disease (AD) is influenced by multiple genetic variants that are involved in five major AD-pathways. Per individual, these pathways may differentially contribute to the modification of the AD-risk. The pathways involved in the resilience against AD have thus far been poorly addressed. Here, we investigated to what...journal article 2020
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D'Olivo, P. (author), van Bindsbergen, Kelly L.A. (author), Huisman, J. (author), Grootenhuis, Martha A. (author), Rozendaal, M.C. (author)In the field of Human-Computer Interaction (HCI), there is an increasing interest in designing for well-being. With this contribution, we introduce Tactful Objects as a design perspective on interactive artifacts that empower people in sensitive settings. We explore the concept of tactfulness by designing two interactive artifacts addressing...journal article 2020
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Mikhaylovskiy, R. V. (author), Huisman, T. J. (author), Gavrichkov, V. A. (author), Polukeev, S. I. (author), Ovchinnikov, S. G. (author), Afanasiev, D. (author), Pisarev, R. V. (author), Rasing, Th (author), Kimel, A. V. (author)The microscopic origin of ultrafast modification of the ratio between the symmetric (J) and antisymmetric (D) exchange interaction in antiferromagnetic iron oxides is revealed, using femtosecond laser excitation as a pump and terahertz emission spectroscopy as a probe. By tuning the photon energy of the laser pump pulse we show that the...journal article 2020
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Huisman, C.J. (author), Mulder, Clara H. (author)Given that insecure leases impact negatively on ontological security and subjective well-being, and given increasing pressure on European housing markets, more insight into insecure leases is timely. In this article, we assess the occurrence of temporary leases in the city of Amsterdam in 2015, and explore the characteristics of the tenants....journal article 2020
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Elghandour, A.M.M.A. (author), Roelvink, D. (author), Huisman, B.J.A. (author), Reyns, J.A.H. (author), Costas, Susana (author), Nienhuis, Jaap (author)Prediction of the shoreline response behind offshore breakwaters is essential for coastal protection projects. Due to the complexity of the processes behind the breakwaters (e.g., wave diffraction, currents, longshore transport), detailed modelling needs high computational efforts. Therefore, simplifying the process effect in a simpler...journal article 2020
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Slobbe, D.C. (author), Klees, R. (author), Farahani, H. (author), Huisman, L. (author), Alberts, Bas (author), Voet, Pierre (author), Doncker, Filip De (author)We present a local quasi-geoid (QG) model which combines a satellite-only global gravity model with local data sets using weighted least squares. The QG is computed for an area comprising the Netherlands, Belgium, and the southern North Sea. It uses a two-scale spherical radial basis function model complemented by bias parameters to account...journal article 2019
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Huisman, B.J.A. (author), Walstra, Dirk Jan R. (author), Radermacher, Max (author), de Schipper, M.A. (author), Ruessink, B. Gerben (author)Shoreface nourishments are commonly applied for coastal maintenance, but their behaviour is not well understood. Bathymetric data of 19 shoreface nourishments located at alongshore uniform sections of the Dutch coast were therefore analyzed and used to validate an efficient method for predicting the erosion of shoreface nourishments. Data shows...journal article 2019
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Kroon, E.J. (author), Huisman, D.J. (author), Bourgeois, Q. P.J. (author), Braekmans, D. (author), Fokkens, H. (author)The introduction of the Corded Ware Culture (3000–2500 BCE) is considered a formative event in Europe's past. Ancient DNA analyses demonstrate that migrations played a crucial role in this event. However, these analyses approach the issue at a supra-regional scale, leaving questions about the regional and local impact of this event unresolved...journal article 2019
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Radermacher, M. (author), de Schipper, M.A. (author), Price, Timothy (author), Huisman, B.J.A. (author), Aarninkhof, S.G.J. (author), Reniers, A.J.H.M. (author)The behaviour of subtidal sandbars can be strongly influenced by the introduction of sand nourishments in the coastal system. This study focuses on the impact of nourishments on subtidal bar behaviour at spatio-temporal scales beyond a single nourishment project. It aims to determine the long-term behaviour of subtidal sandbars along an entire...journal article 2018
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Huisman, B.J.A. (author), Ruessink, B. G. (author), de Schipper, M.A. (author), Luijendijk, Arjen (author), Stive, M.J.F. (author)Large perturbations in the coastline, such as the 'Sand Motor' nourishment (∼21 million m<sup>3</sup>) at the Holland coast, can initiate considerable spatial and temporal changes in the median grain size (D<sub>50</sub>) of the sea bed on the lower shoreface. The relevance of hydrodynamic conditions for the development of the heterogeneity...journal article 2018
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Fluorescence Polarization Control for On-Off Switching of Single Molecules at Cryogenic TemperaturesHulleman, C.N. (author), Huisman, Maximiliaan (author), Moerland, R.J. (author), Gruenwald, David (author), Stallinga, S. (author), Rieger, B. (author)Light microscopy, allowing sub-diffraction-limited resolution, has been among the fastest developing techniques at the interface of biology, chemistry, and physics. Intriguingly no theoretical limit exists on how far the underlying measurement uncertainty can be lowered. In particular data fusion of large amounts of images can reduce the...journal article 2018