Verduurzaming tunnelgietbouw: Beperkte aanpassing, grote impact

Met tunnelgietbouw kunnen snel en tegen lage kosten woningen worden gerealiseerd. Het is dan ook een veel toegepaste bouwmethodiek. Er valt potentieel veel terrein te winnen ten aanzien van milieu-impact door de betonsector.

Evaluating building circularity in the early design phase

Facing circular transition challenges, building circularity should be evaluated in the early design phase to reduce the risks of circular and environmental performance problems found in later project phases. However, due to the current design workflow, such practice is hindered because there is not enough information to evaluate building...

Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting...

Estimating the Safety Effects of Congestion Warning Systems using Carriageway Aggregate Data

Is it possible to use just aggregate carriageway data for the evaluation of congestion warning systems (CWS) in large networks—or any system affecting traffic safety for that matter? In this paper, two hypotheses related to this question are tested. The first hypothesis is that it can be done by comparing large-scale congestion patterns on...

Modelling head injury due to unmanned aircraft systems collision: Crash dummy vs human body

Recent developments in the concept of UAS operations in urban areas have led to risk concerns of UAS collision with human. To better understand this risk, head and neck injuries due to UAS collisions have been investigated by different research teams using crash dummies. Because of the limitations in biofidelity of a crash dummy, head injury...

Optimized ChIP-seq method facilitates transcription factor profiling in human tumors

Chromatin immunoprecipitation (ChIP)-seq analyses of transcription factors in clinical specimens are challenging due to the technical limitations and low quantities of starting material, often resulting in low enrichments and poor signal-to-noise ratio. Here, we present an optimized protocol for transcription factor ChIP-seq analyses in human...

Multibody system modelling of unmanned aircraft system collisions with the human head

Understanding the impact severity of unmanned aircraft system (UAS) collisions with the human body remains a challenge and is essential to the development of safe UAS operations. Complementary to performing experiments of UAS collisions with a crash dummy, a computational impact model is needed in order to capture the large variety of UAS types...

Improving reliability in forensic engineering: the Delft approach

Based on established theories from literature and best practices of forensic investigations in aerospace engineering, civil engineering and biomechanical engineering, the Delft University of Technology has developed a Delft approach<br/>for forensic investigations. This integrated approach consists of three elements. First, because a product has...

Integrative epigenetic taxonomy of primary prostate cancer

The Androgen Receptor (AR) is the key-driving transcription factor in prostate cancer, tightly controlled by epigenetic regulation. To date, most epigenetic profiling has been performed in cell lines or limited tissue samples. Here, to comprehensively study the epigenetic landscape, we perform RNA-seq with ChIP-seq for AR and histone...

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.

A global safety deficiency: False glide slope capture affecting aircraft

A serious incident occurred at Eindhoven Airport (Netherlands) in May 2013. A Boeing 737-800 performed a go-around while using the Instrument Landing System (ILS). The flight crew reported a False Glide Slope capture as the reason for the go-around.<br/>At first the occurrence report did not really gain much attention but when the investigation...

Stedelijk verkeersmanagement: Problemen van nu en richtingen voor de toekomst

Building the fastest bicycle in the world; a year with the Human Power Team Delft & Amsterdam

“Third time lucky” is the saying, but for the third Human Power Team it almost turned out as a year for nothing. The team has been attempting to set the world record for the fastest bicycle powered only by human muscles for two years already. This endeavor to let a Dutchman be the fastest human on earth resulted in a marvelous year with many ups...

Experimental and numerical findings on the long-term evolution of migrating alternate bars in alluvial channels

Migrating alternate bars form in alluvial channels as a result of morphodynamic instability. Extensive literature can be found on their origin and short-term development, but their long-term evolution has been poorly studied so far. In particular, it is not clear whether migrating bars eventually reach a (dynamic) equilibrium, as in previous...

Decision support in dynamic traffic management