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Ooft, Salo N. (author), Weeber, Fleur (author), Dijkstra, Krijn K. (author), McLean, Chelsea M. (author), Kaing, Sovann (author), van Werkhoven, Erik (author), Schipper, Luuk (author), Hoes, Louisa (author), Wessels, L.F.A. (author)There is a clear and unmet clinical need for biomarkers to predict responsiveness to chemotherapy for cancer. We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions to identify nonresponders to standard-of-care chemotherapy in colorectal cancer (CRC). In a prospective clinical study, we show the...journal article 2019
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Esposito, R. (author), Messali, F. (author), Ravenshorst, G.J.P. (author), Schipper, H.R. (author), Rots, J.G. (author)The exploitation of geo-resources in the northern part of the Netherlands (Groningen region) is triggering shallow earthquakes, rising the need of assessing the current building stock. Being the region not prone to tectonic earthquakes, buildings are designed as wind-resistant systems and have specific characteristics that can limit their...journal article 2019
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3D Printing Concrete on temporary surfaces: The design and fabrication of a concrete shell structureBorg Costanzi, C. (author), Ahmed, Z. Y. (author), Schipper, H.R. (author), Bos, F. (author), Knaack, U. (author), Wolfs, R.J.H. (author)One of the geometrical restrictions associated with printed paste materials such as concrete, is that material must be self-supporting during printing. In this research paper a new methodology for 3D Printing Concrete onto a temporary freeform surface is presented. This is achieved by setting up a workflow for combining a Flexible Mould...journal article 2018
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Puente, I. (author), Lindenbergh, R.C. (author), Van Natijne, A. (author), Esposito, R. (author), Schipper, H.R. (author)Vulnerability of buildings to natural and man-induced hazards has become a main concern for our society. Ensuring their serviceability, safety and sustainability is of vital importance and the main reason for setting up monitoring systems to detect damages at an early stage. In this work, a method is presented for detecting changes from laser...journal article 2018
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Schipper, H.R. (author), Hordijk, G.J. (author), Turrin, M. (author), Mureau, M.D.A. (author), Fransen, E.J.H. (author), van Rhijn, Arthur (author)Innovatieve software komt regelmatig op de markt, maar Rhinoceros-Grasshopper heeft een compleet nieuwe wereld aan mogelijkheden ontsloten. Ook voor de bouwfysicus is dit zeer relevant. Doordat gebruik wordt gemaakt van een intuïtieve, parametrische en grafische programmeertaal, kunnen complexe geometrische problemen zeer snel worden...journal article 2018
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Esposito, R. (author), Jafari, S. (author), Ravenshorst, G.J.P. (author), Schipper, H.R. (author), Rots, J.G. (author)In recent years induced seismicity in the Netherlands considerably increased. This phenomenon has a wide impact on the built environment, which is mainly composed by unreinforced masonry (URM) structures. These buildings were not designed for seismic loading, and present peculiar characteristics include very slender walls (100 mm thickness and 2...conference paper 2018
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Wijdeveld, A.J. (author), Schipper, C. A. (author), Heimovaara, T.J. (author)In this study the spatial distribution of dissolved metals in surface water is studied at nine locations in Lake Ketelmeer (the Netherlands). The measured dissolved metal concentrations are combined with the local water quality parameters for salinity, pH, alkalinity and DOC to calculate a FIAM Free Ion Activity Model (FIAM) and the Biotic...journal article 2018
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Terwel, K.C. (author), Schipper, H.R. (author)Groningen, a province in the northern part of the Netherlands, suffers from earthquakes because of gas drilling. The residential building stock in Groningen was not designed for these loads. Over the years a lot of smaller and larger damage has developed, possibly - but not necessarily - caused by the effects of gas drilling. Delft University of...conference paper 2018
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Mast, Danića (author), Schipper, Sylvia (author), van Doorn, F.A.P. (author), Schut, A. (author), Gielen, M.A. (author), de Vries, Sanne (author)This study is carried out within the context of a research and innovation<br/>project Co-design with Kids that aims to support teaching of broad so-called ‘21st<br/>century’ skills. In this project, design toolboxes for use within primary education<br/>are developed and studied, with real life clients and assignments. In the case<br/>described...conference paper 2018
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Schipper, H.R. (author), Grunewald, S. (author), Troian, S. (author), Raghunath, P. (author), Schlangen, E. (author), Copuroglu, Oguzhan (author)Expensive CNC (computer numerical controlled)-milled formwork is required for the production of double-curved precast concrete elements for cladding or shell structures. The innovative flexible mould method for economically efficient and sustainable production of such elements, developed at Delft University of Technology, comprises the use of a...conference paper 2017
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Schipper, H.R. (author), Borg Costanzi, C. (author), Bos, Freek (author), Ahmed, Z (author), Wolfs, R. (author)It is no secret that there have been some great advances in the realm of concrete additive manufacturing. However, one of the major drawbacks of this fabrication technique is that the elements must be self-supporting during printing. While most other additive manufacturing materials can overcome this by using a secondary printed support...working paper 2017
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- Esposito, R. (author), Ravenshorst, G.J.P. (author), Schipper, H.R. (author) report 2017
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Cyclic pushover test on an unreinforced masonry structure reseambling a typical Dutch terraced houseEsposito, R. (author), Terwel, K.C. (author), Ravenshorst, G.J.P. (author), Schipper, H.R. (author), Messali, F. (author), Rots, J.G. (author)During the last years, induced seismicity in the northern part of the Netherlands increased and the seismic assessment of unreinforced masonry (URM) structures became an important issue. As the problem is recent, the current building stock is not designed to withstand earthquakes and national guidelines are under development, but currently not...conference paper 2017
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Greco, A. (author), Konstantinou, T. (author), Schipper, H.R. (author), Binnekamp, R. (author), Gerritsen, Esther (author), van den Dobbelsteen, A.A.J.F. (author)In Europe, the DIRECTIVE 2010/31/EU requires increasing the number of nearly zero energy buildings. The existing building stock needs to be included in order to achieve the 2020 EU environmental targets. The main barriers of energy neutral refurbishment of existing non-residential buildings appear to be financial rather than technical, next to a...conference paper 2017
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- Ravenshorst, G.J.P. (author), Esposito, R. (author), Schipper, H.R. (author), Messali, F. (author), Tsouvalas, A. (author), Lourens, E. (author), Rots, J.G. (author) report 2016
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Merkus, Sander (author), Willems, Thijs (author), Schipper, Danny (author), van Marrewijk, Alfons (author), Koppenjan, Joop (author), Veenswijk, Marcel (author), Bakker, H.L.M. (author)This paper studies the ways in which members of inter-organizational teams collectively make sense of unexpected events and how they decide upon engaging in action. Frequently, ambiguity dominates such change processes aimed to create common understanding. Using the notion of the duality of intrinsic and constructed ambiguity, a detailed...journal article 2016
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Grünewald, S. (author), Schipper, H.R. (author), Hordijk, D.A. (author)The number of applications with thin flat, curved or double-curved elements often produced as architectural elements for façades is rising fast. If the repetition factor of the elements is limited, which is often the case in free-form architecture, the high number of unique moulds makes this type of architecture economically less viable....conference paper 2016
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Schipper, H.R. (author), Eigenraam, P. (author)Practical implications of deforming a flat mould surface into a double-curved shape. Proposal for processing concrete elements with a complex double-curved geometry in an efficient and accurate manner using parametric, associative modelling.journal article 2016
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Greco, A. (author), Konstantinou, T. (author), Schipper, H.R. (author), Binnekamp, R. (author), Gerritsen, E. (author), de Graaf, R.P. (author), van den Dobbelsteen, A.A.J.F. (author)Net zero energy is already an ambitious target for several buildings, especially since the DIRECTIVE 2010/31/EU that requires increasing the number of nearly zero energy buildings. The existing commercial building stock needs to be included in order to achieve the 2020 EU environmental targets. The main barriers of zero energy refurbishment of...conference paper 2016
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Schipper, H.R. (author)The production of precast, concrete elements with complex, double-curved geometry is expensive due to the high costcosts of the necessary moulds and the limited possibilities for mould reuse. Currently, CNC-milled foam moulds are the solution applied mostly in projects, offering good aesthetic performance, but also resulting in waste of material...doctoral thesis 2015