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Mahfouz, A.M.E.T.A. (author), Lelieveldt, B.P.F. (author), Grefhorst, Aldo (author), Mol, Isabel M. (author), Sips, Hetty C.M. (author), van den Heuvel, José K. (author), Visser, Jenny A. (author), Reinders, M.J.T. (author), Meijer, Onno C. (author)Steroid hormones coordinate the activity of many brain regions by binding to nuclear receptors that act as transcription factors. This study uses genome-wide correlation of gene expression in the mouse brain to discover (i) brain regions that respond in a similar manner to particular steroids, (ii) signaling pathways that are used in a steroid...poster 2015
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Mahfouz, A.M.E.T.A. (author), Van de Giessen, M. (author), Van der Maaten, L.J.P. (author), Huisman, S.M.H. (author), Reinders, M.J.T. (author), Hawrylycz, M.J. (author), Lelieveldt, B.P.F. (author)The Allen Brain Atlases enable the study of spatially resolved, genome-wide gene expression patterns across the mammalian brain. Several explorative studies have applied linear dimensionality reduction methods such as Principal Component Analysis (PCA) and classical Multi-Dimensional Scaling (cMDS) to gain insight into the spatial organization...journal article 2014
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Van den Berg, B.A. (author), Reinders, M.J. (author), Roubos, J.A. (author), De Ridder, D. (author)Background Amino acid sequences and features extracted from such sequences have been used to predict many protein properties, such as subcellular localization or solubility, using classifier algorithms. Although software tools are available for both feature extraction and classifier construction, their application is not straightforward,...journal article 2014
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Geelen, D.V. (author), Scheepens, A.E. (author), Kobus, C.B.A. (author), Obinna, U.P. (author), Mugge, R. (author), Schoormans, J.P.L. (author), Reinders, A.H.M.E. (author)Residential smart grid projects can be evaluated by a design-driven approach, which focuses on gaining insights for successful product and service development by taking the end-users as a starting point. Because only little experience exists with this design-driven approach, this paper addresses how four pilot projects with smart energy...conference paper 2013
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Reinders, L.G.A.J. (author)There is something irrevocable in architecture. In contrast with a painting or a musical play, one cannot alter an architectural work of art other than by blowing it up or pulling it down. Streets, buildings, squares and parks are part of the hard, physical environment in which we organize our lives. But why conceptualize architecture as a...doctoral thesis 2013
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Van den Akker, E.B. (author), Passtoors, W.M. (author), Jansen, R. (author), Van Zwet, E.W. (author), Goeman, J.J. (author), Hulsman, M. (author), Emilsson, V. (author), Perola, M. (author), Willemsen, G. (author), Penninx, B.W.J.H. (author), Heijmans, B.T. (author), Maier, A.B. (author), Boomsma, D.I. (author), Kok, J.N. (author), Slagboom, P.E. (author), Reinders, M.J.T. (author), Beekman, M. (author)The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...journal article 2013
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Straver, R. (author), Sistermans, E.A. (author), Holstege, H. (author), Visser, A. (author), Oudejans, C.B.M. (author), Reinders, M.J.T. (author)Genetic disorders can be detected by prenatal diagnosis using Chorionic Villus Sampling, but the 1:100 chance to result in miscarriage restricts the use to fetuses that are suspected to have an aberration. Detection of trisomy 21 cases noninvasively is now possible owing to the upswing of next-generation sequencing (NGS) because a small...journal article 2013
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Taskesen, E. (author), Hoogeboezem, R. (author), Delwel, R. (author), Reinders, M.J.T. (author)Probing protein-deoxyribonucleic acid (DNA) is gaining popularity as it sheds light on molecular mechanisms that regulate the expression of genes. Currently, tiling-arrays and next-generation sequencing technology can be used to measure these interactions. Both methods generate a signal over the genome in which contiguous regions of peaks on the...journal article 2013
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Winterbach, W. (author), Van Mieghem, P. (author), Reinders, M. (author), Wang, H. (author), De Ridder, D. (author)Molecular interactions are often represented as network models which have become the common language of many areas of biology. Graphs serve as convenient mathematical representations of network models and have themselves become objects of study. Their topology has been intensively researched over the last decade after evidence was found that...journal article 2013
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Klijn, C. (author), Koudijs, M.J. (author), Kool, J. (author), Ten Hoeve, J. (author), Boer, M. (author), De Moes, J. (author), Akhtar, W. (author), Van Miltenburg, M. (author), Vendel-Zwaagstra, A. (author), Reinders, M.J.T. (author), Adams, D.J. (author), Van Lohuizen, M. (author), Hilkens, J. (author), Wessels, L.F.A. (author), Jonkers, J. (author)Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer driver genes, and how they contribute to tumor evolution is largely unknown. This study deployed...journal article 2013
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Van Dyk, E. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)Tumor formation is partially driven by DNA copy number changes, which are typically measured using array comparative genomic hybridization, SNP arrays and DNA sequencing platforms. Many techniques are available for detecting recurring aberrations across multiple tumor samples, including CMAR, STAC, GISTIC and KC SMART. GISTIC is widely used and...journal article 2013
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Babaei, S. (author), Hulsman, M. (author), Reinders, M.J.T. (author), De Ridder, J. (author)Background Delineating the molecular drivers of cancer, i.e. determining cancer genes and the pathways which they deregulate, is an important challenge in cancer research. In this study, we aim to identify pathways of frequently mutated genes by exploiting their network neighborhood encoded in the protein-protein interaction network. To this end...journal article 2013
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- Gehrmann, T. (author), Pelkmans, Jordi F. (author), Lugones, Luis G. (author), Wösten, Han A.B. (author), Reinders, M.J.T. (author) poster 2013
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Mahfouz, A.M.E.T.A. (author), Ziats, Mark N. (author), Rennert, Owen M. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)We analyzed the spatial-temporal co-expression relationships of 455 genes previously implicated in Autism spectrum disorder (ASD) using the BrainSpan transcriptome atlas. Understanding how the heterogenous set of ASD-related genes contribute to normal brain development helps identifying cellular/molecular processes which are commonly disrupted...poster 2013
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van den Berg, B.A. (author), Thornton, JM (author), Reinders, M.J.T. (author), de Ridder, D. (author), Beer, TAP (author)Our aim is to prioritize human missense mutations by their probability of being disease causing. Such a computational method could be used to obtain a reduced set of mutations with a relatively large fraction of disease related mutations, thereby aiding in the search for this type of mutation within a large mutation set.<br/><br/>Whereas a range...poster 2013
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Apostolou, G. (author), Reinders, A.H.M.E. (author)In this paper 80 commercially available PV products have been analysed. The data set comprises 46 low power PV products in the range of 0 to 17 Wp and 34 PV products with a power of 17 Wp up to 27 kWp. The goal of our study is to investigate and evaluate features of PV products that are available on the market now and to present features that...conference paper 2012
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Van Geenhuizen, M.S. (author), Schoonman, J. (author), Reinders, A.H.M.E. (author)Places of large potentials of sustainable energy production and places of energy consumption are often very different and separated by large distances across the globe. This paper first discusses potentials of solar technology in terms of global availability using PV technology and actual energy production. Solar energy is widely under-used and...conference paper 2012
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Entrop, A.G. (author), Reinders, A.H.M.E. (author)Er is een experiment uitgevoerd met vier betonnen vloeren in een semiadiabatische omgeving. Twee vloeren bevatten PCMs en, ter referentie, twee vloeren geen PCMs. De opstelling moest op schaal een woning voorstellen met een raam op het zuiden. De omgevingscondities en de temperatuurontwikkelingen in de vloeren en boxen werden gemonitord. Het...journal article 2012
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Van den Berg, B.A. (author), Reinders, M.J.T. (author), Hulsman, M. (author), Wu, L. (author), Pel, H.J. (author), Roubos, J.A. (author), De Ridder, D. (author)Protein sequence features are explored in relation to the production of over-expressed extracellular proteins by fungi. Knowledge on features influencing protein production and secretion could be employed to improve enzyme production levels in industrial bioprocesses via protein engineering. A large set, over 600 homologous and nearly 2,000...journal article 2012
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Viswanathan, B. (author), Reinders, A.H.M.E. (author), De Boer, D.K.G. (author), Ras, A. (author), Zahn, H. (author), Desmet, L. (author)Solar photovoltaic outdoor lighting applications usually comprise flat plate PV modules mounted on top of a light pole. In our paper instead, it is thought of to design the light pole as a luminescent solar concentrator photovoltaic (LSC-PV) module with solar cell strips and hence reduce costs of silicon solar cells because concentration effects...conference paper 2012