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Franchimon, Francesco (author), Koning, Kyra (author), van der Ham, Jonas (author), Voskuilen, Paul (author), Correljé, A. (author), Ersoy, A. (author)Voor dit onderzoek is data verzameld door middel van sleuteldocumenten, interviews en enquêtes. Alle stakeholders zijn individueel geïnterviewd in november 2022 middels een semigestructureerd interview. Hierbij zijn sleuteldocumenten gebruikt om de positie van een bepaalde stakeholdersgroep inzake warmtenetten te kennen, zoals positionpapers van...report 2024
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Koning, A.M. (author)Shallow cumulus clouds interact with their environment and redistribute heat, moisture, and momentum (wind speed and direction) in the atmosphere. The same convective plume that forms the cloud is for a large extent responsible for this transport. Modeling the effect of shallow cumulus clouds is challenging because these clouds are smaller than...doctoral thesis 2023
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van der Werf, Verena M. (author), Zhao, J. (author), Koning, Jim S. (author), Nespoli, J. (author), Thieme, J. (author), Bus, M. (author), Savenije, T.J. (author)Metal-halide perovskites deposited by wet-chemical deposition have demonstrated great potential for various electronic applications, including solar cells. A remaining question is how light-induced excess charges become distributed over such polycrystalline material. Here, we examine the local conductive properties of MAPbI<sub>3</sub> and...journal article 2023
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Dieckman, Tessa (author), Schreurs, Mette (author), Mahfouz, A.M.E.T.A. (author), Kooy-Winkelaar, Yvonne (author), Neefjes-Borst, Andra (author), Bouma, Gerd (author), Koning, Frits (author)Background & Aims: Refractory celiac disease type II (RCDII) is a rare indolent lymphoma in the small intestine characterized by a clonally expanded intraepithelial intracellular CD3<sup>+</sup>surfaceCD3<sup>-</sup>CD7<sup>+</sup>CD56<sup>-</sup> aberrant cell population. However, RCDII pathogenesis is ill-defined. Here, we aimed at...journal article 2022
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Koning, A.M. (author), Nuijens, Louise (author), Mallaun, Christian (author), Witschas, Benjamin (author), Lemmerz, Christian (author)Measurements of wind and momentum fluxes are not typically at the centre of field studies on (shallow) cumulus convection, but the mesoscale organization of convection is likely closely tied to patterns in wind. This study combines in situ high-frequency turbulence measurements from a gust probe onboard a Cessna aircraft with downward profiling...journal article 2022
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van Unen, Vincent (author), Ouboter, Laura F. (author), Li, Na (author), Schreurs, Mette (author), Abdelaal, T.R.M. (author), Kooy-Winkelaar, Yvonne (author), Beyrend, Guillaume (author), Höllt, T. (author), Maljaars, P. W.Jeroen (author), Mearin, M. Luisa (author), Mahfouz, A.M.E.T.A. (author), Witte, Anne M.C. (author), Clemens, Cornelis H.M. (author), Abraham, Sunje (author), Escher, Johanna C. (author), Lelieveldt, B.P.F. (author), Pascutti, M. Fernanda (author), van der Meulen – de Jong, Andrea E. (author), Koning, Frits (author)Chronic intestinal inflammation underlies inflammatory bowel disease (IBD). Previous studies indicated alterations in the cellular immune system; however, it has been challenging to interrogate the role of all immune cell subsets simultaneously. Therefore, we aimed to identify immune cell types associated with inflammation in IBD using high...journal article 2022
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Hammer, T.C. (author), van Beek, C. (author), Koning, J.R.A. (author), Hendrikse, H. (author)With the ongoing development of offshore wind in cold regions where the foundations are exposed to sea ice, there is a strong need for data to validate the numerically predicted dynamic interaction between ice and structure used for design. Full-scale data is non-existent and only a limited number of experimental campaigns in ice tanks have been...conference paper 2021
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Koning, A.M. (author), Nuijens, Louise (author), Bosveld, F. C. (author), Siebesma, A.P. (author), van Dorp, P. A. (author), Jonker, H.J.J. (author)This study investigates how wind shear and momentum fluxes in the surface- and boundary layer vary across wind and cloud regimes. We use a 9-year-long data set from the Cabauw observatory complemented by (8.2 × 8.2 (Formula presented.)) daily Large Eddy Simulation (LES) hindcasts. An automated algorithm classifies observed and simulated days...journal article 2021
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van der Gracht, Esmé T.I. (author), Beyrend, Guillaume (author), Abdelaal, T.R.M. (author), Pardieck, Iris N. (author), Wesselink, Thomas H. (author), van Haften, Floortje J. (author), van Duikeren, Suzanne (author), Koning, Frits (author), Arens, Ramon (author)SummaryFactors that govern the complex formation of memory T cells are not completelyunderstood. A better understanding of thedevelopment of memory Tcell hetero-geneity is however required to enhance vaccination and immunotherapy ap-proaches. Here we examined the impact of pathogen- and tissue-specific cueson memory CD8+T cell heterogeneity...journal article 2021
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Somarakis, Antonios (author), van Unen, Vincent (author), Koning, Frits (author), Lelieveldt, B.P.F. (author), Höllt, T. (author)Tissue functionality is determined by the characteristics of tissue-resident cells and their interactions within their microenvironment. Imaging Mass Cytometry offers the opportunity to distinguish cell types with high precision and link them to their spatial location in intact tissues at sub-cellular resolution. This technology produces large...journal article 2021
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de Vries, Natasja L. (author), Mahfouz, A.M.E.T.A. (author), Koning, Frits (author), de Miranda, Noel F.C.C. (author)Cancers are characterized by extensive heterogeneity that occurs intratumorally, between lesions, and across patients. To study cancer as a complex biological system, multidimensional analyses of the tumor microenvironment are paramount. Single-cell technologies such as flow cytometry, mass cytometry, or single-cell RNA-sequencing have...review 2020
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Velichko, E. (author), Tian, B. (author), Nikolaeva, Tatiana (author), Koning, J.R.A. (author), van Duynhoven, John (author), Bouwman, W.G. (author)A versatile cell for X-ray and neutron scattering experiments on samples under shear has been designed. To our knowledge, it is the first shear cell which can be used for both SAXS and SANS in respectively synchrotron or reactor beamlines. The cell is mainly intended for scattering experiments in so-called “1–2 plane geometry” but can also be...journal article 2019
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Li, Na (author), van Unen, Vincent (author), Guo, Nannan (author), Abdelaal, T.R.M. (author), Somarakis, Antonios (author), Eggermont, Jeroen (author), Mahfouz, A.M.E.T.A. (author), Chuva de Sousa Lopes, Susana M. (author), Lelieveldt, B.P.F. (author), Koning, Frits (author)The human fetal immune system must protect the infant against the sudden exposure to a large variety of pathogens upon birth. While it is known that the fetal immune system develops in sequential waves, relatively little is known about the composition of the innate and adaptive immune system in the tissues. Here, we applied high-dimensional...journal article 2019
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de Vries, N.L. (author), Van Unen, Vincent (author), Ijsselsteijn, Marieke E. (author), Abdelaal, T.R.M. (author), Van Der Breggen, Ruud (author), Farina Sarasqueta, Arantza (author), Mahfouz, A.M.E.T.A. (author), Peeters, Koen C.M.J. (author), Höllt, T. (author), Lelieveldt, B.P.F. (author), Koning, Frits (author), De Miranda, Noel F.C.C. (author)Objective: A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of...journal article 2019
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Kraan, Oscar (author), Kramer, Gert Jan (author), Nikolic, I. (author), Chappin, E.J.L. (author), Koning, Vinzenz (author)Full decarbonisation of the electricity system is one of the key elements to limit global warming. As this transition takes place, the electricity system must maintain system adequacy and remain affordable to consumers. In liberalised electricity markets investors are seen as key actors driving this transition. Due to the intermittent...journal article 2019
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Abdelaal, T.R.M. (author), van Unen, Vincent (author), Höllt, T. (author), Koning, Frits (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)Mass cytometry by time-of-flight (CyTOF) is a valuable technology for high-dimensional analysis at the single cell level. Identification of different cell populations is an important task during the data analysis. Many clustering tools can perform this task, which is essential to identify “new” cell populations in explorative experiments....journal article 2019
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Beyrend, Guillaume (author), van der Gracht, Esmé (author), Yilmaz, Ayse (author), van Duikeren, Suzanne (author), Camps, Marcel (author), Höllt, T. (author), Vilanova Bartroli, A. (author), van Unen, Vincent (author), Koning, Frits (author), de Miranda, Noel F. C. C. (author), Arens, Ramon (author), Ossendorp, Ferry (author)Background: The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of patients. Combination immunotherapy offers an attractive avenue to develop more effective cancer therapies by improving the efficacy and duration of the tumor-specific T-cell...journal article 2019
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Abdelaal, T.R.M. (author), Höllt, T. (author), van Unen, Vincent (author), Lelieveldt, B.P.F. (author), Koning, Frits (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)Motivation: High-dimensional mass cytometry (CyTOF) allows the simultaneous measurement of multiple cellular markers at single-cell level, providing a comprehensive view of cell compositions.<br/>However, the power of CyTOF to explore the full heterogeneity of a biological sample at the singlecell level is currently limited by the number of...journal article 2019
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Redeker, Anke (author), Remmerswaal, Ester B.M. (author), van der Gracht, Esmé T.I. (author), Welten, Suzanne P.M. (author), Höllt, T. (author), Koning, Frits (author), Cicin-Sain, Luka (author), Nikolich-Žugich, Janko (author), ten Berge, Ineke J.M. (author), van Lier, René A. W. (author), van Unen, Vincent (author), Arens, Ramon (author)The relationship between human cytomegalovirus (HCMV) infections and accelerated immune senescence is controversial. Whereas some studies reported a CMV-associated impaired capacity to control heterologous infections at old age, other studies could not confirm this. We hypothesized that these discrepancies might relate to the variability in the...journal article 2018
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Li, Na (author), van Unen, Vincent (author), Höllt, T. (author), Thompson, Allan (author), van Bergen, Jeroen (author), Pezzotti, N. (author), Eisemann, E. (author), Vilanova Bartroli, A. (author), Chuva de Sousa Lopes, S.M. (author), Lelieveldt, B.P.F. (author), Koning, Frits (author)Innate lymphoid cells (ILCs) are abundant in mucosal tissues and involved in tissue homeostasis and barrier function. Although several ILC subsets have been identified, it is unknown if additional heterogeneity exists, and their differentiation pathways remain largely unclear. We applied mass cytometry to analyze ILCs in the human fetal...journal article 2018