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Caso, O. (author), Verhoeven, Wesley (author)
book chapter 2018
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Bracher, J.M. (author), Verhoeven, M.D. (author), Wisselink, H. Wouter (author), Crimi, B. (author), Nijland, Jeroen G. (author), Driessen, Arnold J.M. (author), Klaassen, Paul (author), van Maris, A.J.A. (author), Daran, J.G. (author), Pronk, J.T. (author)
Background: l-Arabinose occurs at economically relevant levels in lignocellulosic hydrolysates. Its low-affinity uptake via the Saccharomyces cerevisiae Gal2 galactose transporter is inhibited by d-glucose. Especially at low concentrations of l-arabinose, uptake is an important rate-controlling step in the complete conversion of these...
journal article 2018
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Bracher, J.M. (author), Martinez-Rodriguez, Oscar A. (author), Dekker, W.J.C. (author), Verhoeven, M.D. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)
Expression of a heterologous xylose isomerase, deletion of the GRE3 aldose-reductase gene and overexpression of genes encoding xylulokinase (XKS1) and non-oxidative pentose-phosphate-pathway enzymes (RKI1, RPE1, TAL1, TKL1) enables aerobic growth of Saccharomyces cerevisiae on d-xylose. However, literature reports differ on whether anaerobic...
journal article 2018
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Papapetridis, I. (author), Verhoeven, M.D. (author), Wiersma, S.J. (author), Goudriaan, M. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)
Simultaneous fermentation of glucose and xylose can contribute to improved productivity and robustness of yeast-based processes for bioethanol production from lignocellulosic hydrolysates. This study explores a novel laboratory evolution strategy for identifying mutations that contribute to simultaneous utilisation of these sugars in batch...
journal article 2018
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Verhoeven, M.D. (author), de Valk, S.C. (author), Daran, J.G. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)
D-Glucose, D-xylose and L-arabinose are major sugars in lignocellulosic hydrolysates. This study explores fermentation of glucose-xylose-arabinose mixtures by a consortium of three ‘specialist’ Saccharomyces cerevisiae strains. A D-glucose- and L-arabinose-tolerant xylose specialist was constructed by eliminating hexose phosphorylation in an...
journal article 2018
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Verhoeven, M.D. (author), Bracher, J.M. (author), Nijland, Jeroen G. (author), Bouwknegt, J. (author), Daran, J.G. (author), Driessen, Arnold J.M. (author)
Cas9-assisted genome editing was used to construct an engineered glucose-phosphorylation-negative S. cerevisiae strain, expressing the Lactobacillus plantaruml-arabinose pathway and the Penicillium chrysogenum transporter PcAraT. This strain, which showed a growth rate of 0.26 h−1 on l-arabinose in aerobic batch cultures, was subsequently...
journal article 2018
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Verhoeven, M.D. (author), Lee, Misun (author), Kamoen, L. (author), van den Broek, M.A. (author), Janssen, Dick B. (author), Daran, J.G. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)
Combined overexpression of xylulokinase, pentose-phosphate-pathway enzymes and a heterologous xylose isomerase (XI) is required but insufficient for anaerobic growth of Saccharomyces cerevisiae on d-xylose. Single-step Cas9-assisted implementation of these modifications yielded a yeast strain expressing Piromyces XI that showed fast aerobic...
journal article 2017
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Jansen, Mickel L.A. (author), Bracher, J.M. (author), Papapetridis, I. (author), Verhoeven, M.D. (author), de Bruijn, J.A. (author), de Waal, P. (author), van Maris, A.J.A. (author), Klaassen, P (author), Pronk, J.T. (author)
The recent start-up of several full-scale ‘second generation’ ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. After a discussion of the challenges that these novel industrial contexts impose on yeast strains,...
journal article 2017
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de Jong, P.M.A. (author), Bussink, F. J L (author), Verhoeven, RPM (author), de Gelder, N (author), van Paassen, M.M. (author), Mulder, Max (author)
journal article 2017
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Martinez-Rubi, O. (author), Verhoeven, S. (author), Van Meersbergen, M. (author), Schûtz, M. (author), Van Oosterom, P. (author), Gonçalves, R. (author), Tijssen, T. (author)
Powered by WebGL, some renderers have recently become available for the visualization of point cloud data over the web, for example Plasio or Potree. We have extended Potree to be able to visualize massive point clouds and we have successfully used it with the second national Lidar survey of the Netherlands, AHN2, with 640 billion points. In...
conference paper 2015
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Romagnoli, G. (author), Verhoeven, M.D. (author), Mans, R. (author), Fleury Rey, Y. (author), Bel-Rhlid, R. (author), Van den Broek, M. (author), Maleki Seifar, R. (author), Ten Pierick, A. (author), Thompson, M. (author), Müller, V. (author), Wahl, S.A. (author), Pronk, J.T. (author), Daran, J.M. (author)
Most available knowledge on fungal arginine metabolism is derived from studies on Saccharomyces cerevisiae, in which arginine catabolism is initiated by releasing urea via the arginase reaction. Orthologues of the S. cerevisiae genes encoding the first three enzymes in the arginase pathway were cloned from Kluyveromyces lactis and shown to...
journal article 2014
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Heusdens, R. (author), Engelen, S. (author), Buist, P.J. (author), Noroozi, A. (author), Sundaramoorthy, P.P. (author), Verhoeven, C.J.M. (author), Bentum, M. (author), Gill, E.K.A. (author)
Pulsars with their periodic pulses and known positions are ideal beacons for navigation. The challenge, however, is the detection of the very weak pulsar signals that are submerged in noise. Radio based approaches allow the use of advanced techniques and methods for the detection and acquisition of such weak signals. In this paper, an effective...
conference paper 2012
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Engelen, S. (author), Gill, E.K.A. (author), Verhoeven, C.J.M. (author)
Satellite swarms, consisting of a large number of identical, miniaturized and simple satellites, are claimed to provide an implementation for specific space missions which require high reliability. However, a consistent model of how reliability and availability on mission level is linked to cost- and time-effective design of the individual swarm...
conference paper 2012
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Veiga, T. (author), Gombert, A.K. (author), Landes, N. (author), Verhoeven, M.D. (author), Kiel, J.A.K.W. (author), Krikken, A. (author), Nijland, J.G. (author), Touw, H. (author), Luttik, M.A.H. (author), Van der Toorn, J.C. (author), Driessen, A.J.M. (author), Bovenberg, R.A.L. (author), Van den Berg, M.A. (author), Van der Klei, I.J. (author), Pronk, J.T. (author), Daran, J.M. (author)
Industrial production of semi-synthetic cephalosporins by Penicillium chrysogenum requires supplementation of the growth media with the side-chain precursor adipic acid. In glucose-limited chemostat cultures of P. chrysogenum, up to 88% of the consumed adipic acid was not recovered in cephalosporin-related products, but used as an additional...
journal article 2012
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Kestilä, A.A. (author), Engelen, S. (author), Gill, E.K.A. (author), Verhoeven, C.J.M. (author), Bentum, M.J. (author), Irahhauten, Z. (author)
Interstellar navigation poses significant challenges in all aspects of a spacecraft. One of them is reliable, low-cost, real-time navigation, especially when there is a considerable distance between Earth and the spacecraft in question. In this paper, a complete system for navigation using pulsar radio emissions is described and analysed. The...
conference paper 2010
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Sundaramoorthy, P.P. (author), Gill, E. (author), Verhoeven, C.J.M. (author)
Embracing reduced requirements and leveraging commercial technology has led to a fast growing small satellite industry. Although most interest in small satellites has hovered around the micro satellites through to the picosatellites, academic interest now extends up to the sub 100 g range of satellites as well. Femto-satellites with a mass range...
conference paper 2010
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Gill, E.K.A. (author), Verhoeven, C. (author), Gill, K. (author), De Milliano, M. (author)
Operations of satellites in Low-Earth Orbit (LEO) have been based on exploiting the maximum time of visibility of satellites over their ground stations. In this paper, it is shown that a key parameter for communication between a satellite and a ground station is not the time of visibility but the amount of telemetry data which can be transmitted...
conference paper 2010
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Verhoeven, C. (author), Bentum, M. (author)
journal article 2010
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Bentum, M.J. (author), Verhoeven, C.J.M. (author), Boonstra, A.J. (author), Van der Veen, A.J. (author), Gill, E.K.A. (author)
OLFAR, Orbiting Low Frequency Antennas for Radio Astronomy, will be a space mission to observe the universe frequencies below 30 MHz, as it was never done before with an orbiting telescope. Because of the ionospheric scintillations below 30 MHz and the opaqueness of the ionosphere below 15 MHz, a space mission is the only opportunity for this as...
conference paper 2009
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De Milliano, M.J. (author), Verhoeven, C.J.M. (author)
The communication systems currently used on nanosatellites are usually well-proven commercial-off-the-shelf units with data rates up to 9.6 kbps. A careful analysis shows that by using advancements in microelectronics, a higher communication performance can be achieved, even within the power and mass limitations of a nanosatellite. This paper...
conference paper 2008
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