Gomez de Santos, P. (author), Cervantes, Fadia V. (author), Tieves, F. (author), Plou, Francisco J. (author), Hollmann, F. (author), Alcalde, Miguel (author) By mimicking the role of human liver P450 monooxygenases, fungal unspecific peroxygenases (UPOs) can perform a range of highly selective oxyfunctionalization reactions on pharmacological compounds, including O-dealkylations and hydroxylations, thereby simulating drug metabolism. Here we have benchmarked human drug metabolite (HDM) synthesis...
journal article 2019
