Selective Water Addition: Investigations of hydratases from the genus Rhodococcus

Water addition reactions to (un)-activated double bonds are very rewarding reactions as they elegantly introduce a hydroxyl-group thereby often adding value to the generated product by establishing a novel stereocentre in tertiary, chiral alcohols. However, performing selective water addition reactions is an extremely challenging task using...

Enantioselective Michael Addition of Water

The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important ?-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent...