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Bouwknegt, J. (author), Koster, C.C. (author), Vos, A.M. (author), Ortiz Merino, R.A. (author), Wassink, Mats (author), Luttik, M.A.H. (author), van den Broek, M.A. (author), Hagedoorn, P.L. (author), Pronk, J.T. (author)Background: In most fungi, quinone-dependent Class-II dihydroorotate dehydrogenases (DHODs) are essential for pyrimidine biosynthesis. Coupling of these Class-II DHODHs to mitochondrial respiration makes their in vivo activity dependent on oxygen availability. Saccharomyces cerevisiae and closely related yeast species harbor a cytosolic Class...journal article 2021
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de Maar, Josanne S. (author), Rousou, Charis (author), van Elburg, Benjamin (author), Vos, H.J. (author), Lajoinie, Guillaume P.R. (author), Bos, Clemens (author), Moonen, Chrit T.W. (author), Deckers, Roel (author)Chemotherapy efficacy is often reduced by insufficient drug uptake in tumor cells. The combination of ultrasound and microbubbles (USMB) has been shown to improve drug delivery and to enhance the efficacy of several drugs in vitro and in vivo, through effects collectively known as sonopermeation. However, clinical translation of USMB therapy...journal article 2021
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Collado Lara, G. (author), Heymans, Sophie V. (author), Rovituso, M. (author), Carlier, Bram (author), Toumia, Yosra (author), Verweij, M.D. (author), Vos, H.J. (author), de Jong, N. (author), Daeichin, V. (author)The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous...journal article 2021
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de Vries, R. (author), van Arnhem, N. (author), Sinnige, T. (author), Vos, Roelof (author), Veldhuis, L.L.M. (author)This article describes an experimental investigation of the aerodynamic interaction that occurs between distributed propellers in forward flight. To this end, three propellers were installed in close proximity in a wind tunnel, and the changes in their performance, flow-field characteristics, and noise production were quantified using...journal article 2021
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Bouwknegt, J. (author), Koster, C.C. (author), Vos, A.M. (author), Ortiz Merino, R.A. (author), Wassink, Mats (author), Luttik, M.A.H. (author), van den Broek, M.A. (author), Hagedoorn, P.L. (author), Pronk, J.T. (author)Following publication of the original article [1], the authors reported errors in the text of the Results section and in Table 2. It refers to a mutation in a yeast gene as VPS1<sup>I410L</sup> and to the corresponding change in the Vps1 amino-acid sequence as I410L. The correct descriptions should read VPS1<sup>I401L</sup> and I401L,...journal article 2021
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Salles, Sebastien (author), Shepherd, Jami (author), Vos, Hendrik J. (author), Renaud, G.G.J. (author)Intraosseous blood circulation is thought to have a critical role in bone growth and remodeling, fracture healing, and bone disorders. However, it is rarely considered in clinical practice because of the absence of a suitable noninvasive in vivo measurement technique. In this work, we assessed blood perfusion in tibial cortical bone...journal article 2021
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Jin, Junling (author), Verbeurgt, J. (author), De Sloover, Lars (author), Stal, Cornelis (author), Deruyter, Greet (author), Montreuil, Anne Lise (author), Vos, S.E. (author), De Maeyer, Philippe (author), De Wulf, Alain (author)Beach Surface Moisture (BSM) is a key attribute in the coastal investigations of land-atmospheric water and energy fluxes, groundwater resource budgets and coastal beach/dune development. In this study, an attempt has been made for the first time to estimate BSM from terrestrial LiDAR intensity data based on the Support Vector Regression (SVR...journal article 2021
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Anders, K.P. (author), Winiwarter, L. (author), Mara, H. (author), Lindenbergh, R.C. (author), Vos, S.E. (author), Höfle, B. (author)Near-continuously acquired terrestrial laser scanning (TLS) data contains valuable information on natural surface dynamics. An important step in geographic analyses is to detect different types of changes that can be observed in a scene. For this, spatiotemporal segmentation is a time series-based method of surface change analysis that...journal article 2021
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di Biase, V. (author), Hanssen, R.F. (author), Vos, S.E. (author)Anthropogenic activities and climate change in coastal areas require continuous monitoring for a better understanding of environmental evolution and for the implementation of protection strate-gies. Surface moisture is one of the important drivers of coastal variability because it highly affects shoreward sand transport via aeolian processes....journal article 2021
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Poppema, Daan W. (author), Wijnberg, Kathelijne M. (author), Mulder, Jan P.M. (author), Vos, S.E. (author), Hulscher, Suzanne J.M.H. (author)In sandy environments, like the beach-dune system, buildings not only affect the airflow, but also the aeolian sediment transport in their surroundings. In this study, we determine how the horizontal size of sediment deposition patterns around buildings depends on the building's dimensions. Four one-day experiments were conducted at the beach...journal article 2021
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Wei, Luxi (author), Wahyulaksana, G. (author), Meijlink, Bram (author), Ramalli, Alessandro (author), Noothout, E.C. (author), Verweij, M.D. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Vos, H.J. (author)Volumetric ultrasound imaging of blood flow with microbubbles enables a more complete visualization of the microvasculature. Sparse arrays are ideal candidates to perform volumetric imaging at reduced manufacturing complexity and cable count. However, due to the small number of transducer elements, sparse arrays often come with high clutter...journal article 2021
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van Arnhem, N. (author), de Vries, R. (author), Sinnige, T. (author), Vos, Roelof (author), Veldhuis, L.L.M. (author)In this combined experimental and numerical study, the propeller–airframe aerodynamic interaction is characterized for an aircraft configuration with propellers mounted to the horizontal tailplane. The contributions of the propeller and airframe to the overall loading are distinguished in the experimental analyses by using a combination of...journal article 2021
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- Venot, Jean Philippe (author), Vos, Jeroen (author), Zwarteveen, Margreet (author), Mdee, Anna (author), Ertsen, M.W. (author), Cleaver, Frances (author), Lankford, Bruce (author), Swatuk, Larry (author), Linton, Jamie (author), Harris, Leila M. (author) journal article 2021
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Lane, R. (author), Vos, Y. (author), Wolters, A.E. (author), van Kessel, L.C.P.M. (author), Chen, S. Elisa (author), Liv, Nalan (author), Klumperman, Judith (author), Giepmans, Ben N.G. (author), Hoogenboom, J.P. (author)Large-scale electron microscopy (EM) allows analysis of both tissues and macromolecules in a semi-automated manner, but acquisition rate forms a bottleneck. We reasoned that a negative bias potential may be used to enhance signal collection, allowing shorter dwell times and thus increasing imaging speed. Negative bias potential has previously...journal article 2021
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Kooijman, L. (author), Dodou, D. (author), Jansen, S. T. (author), Themans, T. S. (author), Russell, J. N.M. (author), Petermeijer, S.M. (author), Doorman, J. R.C. (author), Hablé, J. H. (author), Neubert, D. S. (author), Vos, M. J.C. (author), de Winter, J.C.F. (author)Much psychological research uses pupil diameter measurements to investigate the cognitive and emotional effects of visual stimuli. A potential problem is that accommodating at a nearby point causes the pupil to constrict. This study examined to what extent accommodation is a confounder in pupillometry research. Participants solved...journal article 2021
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Voorneveld, J.D. (author), Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), Mutluer, Ferit O. (author), van der Steen, A.F.W. (author), Ten Cate, Folkert (author), de Jong, N. (author), Vos, H.J. (author), Van den Bosch, Annemien E. (author), Bosch, Johan G. (author)High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion...journal article 2021
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Waasdorp, R. (author), Mugge, W. (author), Vos, H.J. (author), De Groot, Jurriaan H. (author), Verweij, M.D. (author), de Jong, N. (author), Schouten, A.C. (author), Daeichin, V. (author)Skeletal muscles generate force, enabling movement through a series of fast electro-mechanical activations coordinated by the central nervous system. Understanding the underlying mechanism of such fast muscle dynamics is essential in neuromuscular diagnostics, rehabilitation medicine and sports biomechanics. The unique combination of...journal article 2021
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Roelofs, M.N. (author), Kurowicka, D. (author), Vos, Roelof (author)Technology forecasting is an essential starting point for conceptual design of any complex engineering system. In fact, many research projects are focused on developing a small set of promising technologies to a suitable readiness level. However, selecting a set of technologies from a larger pool is a nontrivial task, opposed by uncertainty...journal article 2021
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Vos, J. (author), Farah, H. (author), Hagenzieker, Marjan (author)The actual speed behaviour when drivers approach a curve is very relevant to assess the road design and safety but is mostly overlooked in the scientific literature. Most research into curve driving behaviour is focussed at the behaviour inside the curve, although the speed selection is done before curve entry. The main objective of this...journal article 2021
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Perli, T. (author), Vos, A.M. (author), Bouwknegt, J. (author), Dekker, W.J.C. (author), Wiersma, S.J. (author), Mooiman, C. (author), Ortiz Merino, R.A. (author), Daran, J.G. (author), Pronk, J.T. (author)Neocallimastigomycetes are unique examples of strictly anaerobic eukaryotes. This study investigates how these anaerobic fungi bypass reactions involved in synthesis of pyridine nucleotide cofactors and coenzyme A that, in canonical fungal pathways, require molecular oxygen. Analysis of Neocallimastigomycetes proteomes identified a candidate...journal article 2021