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Venkatraghavan, Vikram (author), Vinke, Elisabeth J. (author), Bron, Esther E. (author), Niessen, W.J. (author), Arfan Ikram, M. (author), Klein, S. (author), Vernooij, Meike W. (author)Data-driven disease progression models have provided important insight into the timeline of brain changes in AD phenotypes. However, their utility in predicting the progression of pre-symptomatic AD in a population-based setting has not yet been investigated. In this study, we investigated if the disease timelines constructed in a case...journal article 2021
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Venkatraghavan, Vikram (author), Klein, S. (author), Fani, Lana (author), Ham, Leontine S. (author), Vrooman, Henri (author), Ikram, M. Kamran (author), Niessen, W.J. (author), Bron, Esther E. (author)Alzheimer's disease (AD) is the most common form of dementia and is phenotypically heterogeneous. APOE is a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM). Since DEBM is a data...journal article 2020