Supportive interventions for family caregivers of patients with advanced cancer: A systematic review

Objective: Family caregivers are often intensively involved in palliative and end-of-life cancer care. A variety of interventions to support family caregivers have been developed, differing in target population, modality, and components. We aimed to systematically examine characteristics and the effectiveness of interventions to support...

Consensus definition of advance care planning in dementia: A 33-country Delphi study

INTRODUCTION: Existing advance care planning (ACP) definitional frameworks apply to individuals with decision-making capacity. We aimed to conceptualize ACP for dementia in terms of its definition and issues that deserve particular attention. METHODS: Delphi study with phases: (A) adaptation of a generic ACP framework by a task force of the...

The role of acculturation in the process of advance care planning among Chinese immigrants: A narrative systematic review

Background: Acculturation is the process of two different cultures coming into contact. It is unclear how acculturation influences Chinese immigrants’ engagement in advance care planning due to the complexity and multifaceted nature of both acculturation and advance care planning. Aims: To synthesize evidence regarding the role of Chinese...

Metro Mapping: development of an innovative methodology to co-design care paths to support shared decision making in oncology

Treatment decision-making can be complex, notably when there are multiple treatments available, with different (probabilities of) benefits and harms, for example, survival and side effects.1 It is precisely in these complex situations that the preferences of the patient are of utmost importance, as the trade-offs of benefits and harms are...

Experiences and perceptions of continuous deep sedation: An interview study among Dutch patients and relatives

Background: The incidence of continuous deep sedation (CDS) has more than doubled over the last decade in The Netherlands, while reasons for this increase are not fully understood. Patients and relatives have an essential role in deciding on CDS. We hypothesize that the increase in CDS practice is related to the changing role of patients and...

Unmet care needs of patients with advanced cancer and their relatives: multicentre observational study

Objectives: The care needs of patients with advanced cancer and their relatives change throughout the disease trajectory. This study focused on the care-related problems and needs of patients with advanced cancer and their relatives. This was done from the perspective of centres for information and support. Methods: This cross-sectional study...

Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation

Accumulating evidence demonstrates important roles for metabolism in cell fate determination. However, it is a challenge to assess metabolism at a spatial resolution that acknowledges both heterogeneity and cellular dynamics in its tissue microenvironment. Using a multi-omics platform to study cell-type-specific dynamics in metabolism in...

Analyzing cell-type-specific dynamics of metabolism in kidney repair

A common drawback of metabolic analyses of complex biological samples is the inability to consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this limitation, we present an advanced high-spatial-resolution metabolomics approach using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI...

The bigger picture of shared decision making: A service design perspective using the care path of locally advanced pancreatic cancer as a case

Purpose: Solutions to improve the implementation of shared decision making (SDM) in oncology often focus on the consultation, with limited effects. In this study, we used a service design perspective on the care path of locally advanced pancreatic cancer (LAPC). We aimed to understand how experiences of patients, their significant others, and...

Mapping atmospheric aerosols with a citizen science network of smartphone spectropolarimeters

To assess the impact of atmospheric aerosols on health, climate, and air traffic, aerosol properties must be measured with fine spatial and temporal sampling. This can be achieved by actively involving citizens and the technology they own to form an atmospheric measurement network. We establish this new measurement strategy by developing and...