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Ioannou, O. (author), Geldermans, Bob (author), Klein, T. (author), Wandl, Alex (author)This paper introduces a methodological framework to integrate circularity in architectural curricula and the building blocks that led to its conceptualisation. The first block (Part A) examines how complexity has affected learning and architectural education, in particular. The paper departs from the notion that knowledge produces further...journal article 2022
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Azcarate Aguerre, J.F. (author), Klein, T. (author), Konstantinou, T. (author), Veerman, Martijn (author)The servitisation of the built environment, through the implementation of product–service systems, is considered a promising business strategy to achieve a circular economy transition. This servitisation faces a number of practical challenges, among them the technological readiness and effective integration and application of existing and...journal article 2022
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Kragt, A.J.J. (author), van den Ham, E.R. (author), Sentjens, H. (author), Netherlands, Eindhoven (author), Klein, T. (author)The type of glazing implemented in a building plays an important role in the heat management of a building. Solar heat entering through glazing causes overheating of interior spaces and increases building’s cooling load. In this work, the energy saving potential of window films based on Cholesteric Liquid Crystals (CLC) is explored. This...journal article 2022
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Azcarate Aguerre, J.F. (author), Conci, Mira (author), Zils, Markus (author), Hopkinson, Peter (author), Klein, T. (author)The regulatory drive to accelerate the clean energy and circular economy transitions in the European building stock is currently failing to overcome systemic implementation barriers. These barriers include high initial investment costs, misaligned financial incentives among stakeholders, and the relatively low cost of less sustainable energy and...journal article 2022
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He, Songbo (author), Kramer, Thomas Sjouke (author), Klein, Frederike Gerda Hiltje (author), Chandel, Anshu (author), Tegudeer, Zhuorigebatu (author), Heeres, Andre (author), Liu, C. (author), Pidko, E.A. (author), Heeres, Hero Jan (author)The catalytic conversion of glycerol to aromatics (GTA, e.g., benzene, toluene, and xylenes, BTX) over a shaped H-ZSM-5/Al<sub>2</sub>O<sub>3</sub> (60/40 wt%) catalyst was investigated in a continuous fixed-bed reactor to study the addition of the Al<sub>2</sub>O<sub>3</sub> binder in the catalyst formulation on catalyst performance. The...journal article 2022
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Eslami Mossallam, B. (author), Klein, M. (author), Smagt, Constantijn V.D. (author), Sanden, Koen V.D. (author), Jones, Stephen K. (author), Hawkins, John A. (author), Finkelstein, Ilya J. (author), Depken, S.M. (author)The S. pyogenes (Sp) Cas9 endonuclease is an important gene-editing tool. SpCas9 is directed to target sites based on complementarity to a complexed single-guide RNA (sgRNA). However, SpCas9-sgRNA also binds and cleaves genomic off-targets with only partial complementarity. To date, we lack the ability to predict cleavage and binding activity...journal article 2022
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Starmans, Martijn P.A. (author), Timbergen, Milea J.M. (author), Vos, Melissa (author), Renckens, Michel (author), Grünhagen, Dirk J. (author), van Leenders, Geert J.L.H. (author), Niessen, W.J. (author), Visser, Jacob J. (author), Klein, Stefan (author)Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs’ molecular analysis. The aim of this study was to evaluate radiomics for distinguishing GISTs from other intra-abdominal tumors, and in GISTs, predict the c-KIT, PDGFRA, BRAF mutational status, and mitotic...journal article 2022
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Malubhoy, Zahabiya (author), Bahia, Frederico Mendonça (author), de Valk, Sophie Claire (author), de Hulster, A.F. (author), Rendulić, Toni (author), Ortiz, Juan Paulo Ragas (author), Xiberras, Joeline (author), Klein, Mathias (author), Mans, R. (author), Nevoigt, Elke (author)Background: The microbial production of succinic acid (SA) from renewable carbon sources via the reverse TCA (rTCA) pathway is a process potentially accompanied by net-fixation of carbon dioxide (CO<sub>2</sub>). Among reduced carbon sources, glycerol is particularly attractive since it allows a nearly twofold higher CO<sub>2</sub>-fixation...journal article 2022
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Schöffer, S.I. (author), Klein, S.A. (author), Aravind, P.V. (author), Pecnik, Rene (author)New technologies are being developed to produce electricity cleaner and more efficient. Promising technologies among these are the solid oxide fuel cell and the supercritical carbon dioxide Brayton cycle. This study investigates the potential of integrating both technologies. The solid oxide fuel cell is known as a potentially clean and...journal article 2021
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Bron, Esther E. (author), Klein, Stefan (author), Papma, Janne M. (author), Jiskoot, Lize C. (author), Venkatraghavan, Vikram (author), Linders, Jara (author), Aalten, Pauline (author), De Deyn, Peter Paul (author), Niessen, W.J. (author)This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network ...journal article 2021
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Sabidussi, E. R. (author), Klein, S. (author), Caan, M. W.A. (author), Bazrafkan, S. (author), den Dekker, A. J. (author), Sijbers, J. (author), Niessen, W.J. (author), Poot, D.H.J. (author)In this paper, we propose the use of Recurrent Inference Machines (RIMs) to perform T<sub>1</sub> and T<sub>2</sub> mapping. The RIM is a neural network framework that learns an iterative inference process based on the signal model, similar to conventional statistical methods for quantitative MRI (QMRI), such as the Maximum Likelihood...journal article 2021
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Venkatraghavan, Vikram (author), Vinke, Elisabeth J. (author), Bron, Esther E. (author), Niessen, W.J. (author), Arfan Ikram, M. (author), Klein, S. (author), Vernooij, Meike W. (author)Data-driven disease progression models have provided important insight into the timeline of brain changes in AD phenotypes. However, their utility in predicting the progression of pre-symptomatic AD in a population-based setting has not yet been investigated. In this study, we investigated if the disease timelines constructed in a case...journal article 2021
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Padoan, R. (author), Klein, Marvin E. (author), Groves, R.M. (author), de Bruin, Gerrit (author), Steemers, Ted A.G. (author), Strlič, Matija (author)Ageing of historical documents often results in changes in the optical properties of the constituent materials. Imaging spectroscopy (IS) can be a valuable tool for monitoring of such changes, if the method fulfils two important conditions. Firstly, compared to natural ageing, the accumulated light dose from repeated measurements of the...journal article 2021
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Paunović, Nevena (author), Bao, Yinyin (author), Coulter, Fergal Brian (author), Masania, K. (author), Geks, Anna Karoline (author), Klein, Karina (author), Rafsanjani, Ahmad (author), Cadalbert, Jasmin (author), Franzen, Daniel (author)Central airway obstruction is a life-threatening disorder causing a high physical and psychological burden to patients. Standard-of-care airway stents are silicone tubes, which provide immediate relief but are prone to migration. Thus, they require additional surgeries to be removed, which may cause tissue damage. Customized bioresorbable airway...journal article 2021
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Haghighi, Z. (author), Dehnavi, Mahboubeh Angali (author), Konstantinou, T. (author), van den Dobbelsteen, A.A.J.F. (author), Klein, T. (author)Researchers have reported that despite technological development in photovoltaic technology and substantial cost reduction, there is still a narrow interest in architectural photovoltaic applications (APA). Lack of interest is correlated to various bottlenecks, and one of them is a lack of knowledge among architects on the possibilities and...journal article 2021
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Li, Bo (author), Niessen, W.J. (author), Klein, Stefan (author), de Groot, Marius (author), Ikram, M. Arfan (author), Vernooij, Meike W. (author), Bron, Esther E. (author)This work presents a single-step deep-learning framework for longitudinal image analysis, coined Segis-Net. To optimally exploit information available in longitudinal data, this method concurrently learns a multi-class segmentation and nonlinear registration. Segmentation and registration are modeled using a convolutional neural network and...journal article 2021
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Angus, Lindsay (author), Starmans, M.P.A. (author), Rajicic, Ana (author), Odink, Arlette E. (author), Jalving, Mathilde (author), Niessen, W.J. (author), Visser, Jacob J. (author), Sleijfer, Stefan (author), Klein, Stefan (author), van der Veldt, Astrid A.M. (author)Patients with BRAF mutated (BRAF-mt) metastatic melanoma benefit significantly from treatment with BRAF inhibitors. Currently, the BRAF status is determined on archival tumor tissue or on fresh tumor tissue from an invasive biopsy. The aim of this study was to evaluate whether radiomics can predict the BRAF status in a non-invasive manner....journal article 2021
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Castillo, J.M. (author), Starmans, M.P.A. (author), Arif, M. (author), Niessen, W.J. (author), Klein, Stefan (author), Bangma, Chris H. (author), Schoots, Ivo G. (author), Veenland, J.F. (author)Radiomics applied in MRI has shown promising results in classifying prostate cancer lesions. However, many papers describe single-center studies without external validation. The issues of using radiomics models on unseen data have not yet been sufficiently addressed. The aim of this study is to evaluate the generalizability of radiomics...journal article 2021
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Huizinga, W. (author), Poot, D.H.J. (author), Vinke, E. J. (author), Wenzel, F. (author), Bron, E. E. (author), Ikram, M. A. (author), Niessen, W.J. (author), Vernooij, M. W. (author), Klein, S. (author)For the segmentation of magnetic resonance brain images into anatomical regions, numerous fully automated methods have been proposed and compared to reference segmentations obtained manually. However, systematic differences might exist between the resulting segmentations, depending on the segmentation method and underlying brain atlas. This...journal article 2021
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Venkatraghavan, Vikram (author), Klein, S. (author), Fani, Lana (author), Ham, Leontine S. (author), Vrooman, Henri (author), Ikram, M. Kamran (author), Niessen, W.J. (author), Bron, Esther E. (author)Alzheimer's disease (AD) is the most common form of dementia and is phenotypically heterogeneous. APOE is a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM). Since DEBM is a data...journal article 2020