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Poot, D.H.J. (author), van der Heijden, R.A.J. (author), van Middelkoop, Marienke (author), Oei, Edwin H.G. (author), Klein, S. (author)Purpose: To identify the optimal combination of pharmacokinetic model and arterial input function (AIF) for quantitative analysis of blood perfusion in the patellar bone using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Materials and Methods: This method design study used a random subset of five control subjects from an...journal article 2018
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huizinga, w (author), Poot, D.H.J. (author), Vernooij, Meike W. (author), Roshchupkin, G.V. (author), bron, E.E. (author), Ikram, M.A. (author), Rueckert, D. (author), Niessen, W.J. (author), Klein, S. (author)Both normal aging and neurodegenerative disorders such as Alzheimer's disease (AD) cause morphological changes of the brain. It is generally difficult to distinguish these two causes of morphological change by visual inspection of magnetic resonance (MR) images. To facilitate making this distinction and thus aid the diagnosis of...journal article 2018
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Guyader, Jean Marie (author), Huizinga, W. (author), Poot, D.H.J. (author), van Kranenburg, Matthijs (author), Uitterdijk, André (author), Niessen, W.J. (author), Klein, S. (author)The most widespread technique used to register sets of medical images consists of selecting one image as fixed reference, to which all remaining images are successively registered. This pairwise scheme requires one optimization procedure per pair of images to register. Pairwise mutual information is a common dissimilarity measure applied to a...journal article 2018
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Aydoğan, Reyhan (author), Marsa Maestre, I. (author), Klein, Mark (author), Jonker, C.M. (author)Automated negotiation mechanisms can be helpful in contexts where users want to reach mutually satisfactory agreements about issues of shared interest, especially for complex problems with many interdependent issues. A variety of automated negotiation mechanisms have been proposed in the literature. The effectiveness of those mechanisms, however...journal article 2018
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Meeuwsen, F.C. (author), Guédon, A.C.P. (author), Klein, J. (author), van der Elst, Maarten (author), Dankelman, J. (author), van den Dobbelsteen, J.J. (author)Introduction: Electrosurgery is used in 80% of surgical procedures. The technique allows surgeons to skilfully dissect tissues and achieve haemostasis. Since improper use of electrosurgery can lead to serious adverse events, training is required to potentially reduce the number and severity of these events. In this study we evaluate education...journal article 2018
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van der Heijden, R.A.J. (author), Poot, D.H.J. (author), Ekinci, Melek (author), Kotek, Gyula (author), van Veldhoven, Peter L.J. (author), Klein, S. (author), Verhaar, Jan A.N. (author), Krestin, Gabriel P. (author), Bierma-Zeinstra, Sita M.A. (author), van Middelkoop, Marienke (author), Oei, Edwin H.G. (author)Background: Altered perfusion might play an important role in the pathophysiology of patellofemoral pain (PFP), a common knee complaint with unclear pathophysiology. Purpose: To investigate differences in dynamic contrast-enhanced (DCE)-MRI perfusion parameters between patients with PFP and healthy control subjects. Population/Subjects...journal article 2018
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Klein, M. (author), Eslami Mossallam, B. (author), Gonzalez Arroyo, D.W. (author), Depken, S.M. (author)Due to their specificity, efficiency, and ease of programming, CRISPR-associated nucleases are popular tools for genome editing. On the genomic scale, these nucleases still show considerable off-target activity though, posing a serious obstacle to the development of therapies. Off targeting is often minimized by choosing especially high...journal article 2018
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Guerra Santin, O. (author), Bosch, H. (author), Budde, P. (author), Konstantinou, T. (author), Boess, S.U. (author), Klein, T. (author), Silvester, S. (author)A number of facade solutions have been developed in recent years to solve the problem of large-scale renovation of housing. In the Netherlands, housing associations have the ambition to achieve an energy-neutral renovation approach, and so, some aim at energy neutrality. However, few address the complexity of multi-family rental dwellings and...journal article 2018
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Prieto Hoces, A.I. (author), Knaack, U. (author), Klein, T. (author), Auer, Thomas (author)Cooling demands in buildings have drastically increased in recent decades and this trend is set to continue into the near future, due to increasing standards of living and global climate change, among the most relevant factors. Besides energy consumption, the use of refrigerants in common vapour compression cooling technologies is a source of...journal article 2018
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Louter, P.C. (author), Akilo, M.A. (author), Miri, Bahareh (author), Neeskens, Tim (author), Ribeiro Silveira, Rafael (author), Topcu, Özhan (author), van der Weijde, Iris (author), Zha, Congrui (author), Bilow, M. (author), Turrin, M. (author), Klein, T. (author), O'Callaghan, James (author)Thin glass – such as commonly applied for displays and touchscreen on electronic devices like smartphone and tablets – offers interesting characteristics for architectural applications. Due to its high strength and small thickness the glass can easily be bent in architecturally appealing curvatures, while the small thickness of the glass offers...journal article 2018
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Azcarate Aguerre, J.F. (author), den Heijer, A.C. (author), Klein, T. (author)The Circular Economy (CE) attempts to realign business incentives, across all fields of human industry, to support the preservation of raw materials within closed economic loops. Within this conceptual frame, Product-Service Systems (PSS) combine the use of tangible products such as building technologies, with intangible maintenance and...journal article 2017
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Martinez Lombardia, Esther (author), Lapeire, Linsey (author), Maurice, Vincent (author), De Graeve, Iris (author), Klein, Lorena (author), Marcus, Philippe (author), Verbeken, Kim (author), Kestens, L.A.I. (author), Gonzalez Garcia, Y. (author), Mol, J.M.C. (author), Terryn, H.A. (author)When aiming for an increased and more sustainable use of metals a thorough knowledge of the corrosion phenomenon as function of the local metal microstructure is of crucial importance. In this work, we summarize the information presented in our previous publications[1-3] and present an overview of the different local (electrochemical) techniques...journal article 2017
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Klein, M. (author), Chandradoss, S.D. (author), Depken, S.M. (author), Joo, C. (author)MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss...journal article 2017
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Sun, Wei (author), Poot, D.H.J. (author), Smal, Ihor (author), Yang, Xuan (author), Niessen, W.J. (author), Klein, S. (author)Image registration is typically formulated as an optimization process, which aims to find the optimal transformation parameters of a given transformation model by minimizing a cost function. Local minima may exist in the optimization landscape, which could hamper the optimization process. To eliminate local minima, smoothing the cost function...journal article 2017
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Guerra Santin, O. (author), Boess, S.U. (author), Konstantinou, T. (author), Romero Herrera, N.A. (author), Klein, T. (author), Silvester, S. (author)Large differences between the expected and actual energy consumption have been found in energy efficient dwellings. Research has shown that these differences are partially caused by occupant behaviour. The financing and payback periods of low carbon technologies are often uncertain because of the impact of the occupants on building...journal article 2017
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- Guédon, A.C.P. (author), Spruit, S. (author), Wauben, L.S.G.L. (author), van der Elst, M. (author), Doorn, N. (author), Dankelman, J. (author), van den Dobbelsteen, J.J. (author), Klein, J. (author) journal article 2017
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Prieto Hoces, A.I. (author), Knaack, U. (author), Klein, T. (author), Auer, T (author)This paper seeks to present a panorama of cooling related research in office buildings, categorising reported research experiences from the past 25 years in order to identify knowledge gaps and define current paths and trends for further exploration. The general goal behind this research is to support the design of sustainable office...journal article 2017
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Prieto Hoces, A.I. (author), Knaack, U. (author), Auer, Thomas (author), Klein, T. (author)Solar energy has been actively promoted as a clean energy source since 1973’s oil crisis, evidenced by the emergence of initiatives such as the Solar Heating & Cooling Programme of the International Energy Agency or the US Department of Energy. Nonetheless, solar technologies have not been widely used in the built environment, limiting their...journal article 2017
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Prieto Hoces, A.I. (author), Knaack, U. (author), Auer, Thomas (author), Klein, T. (author)Solar cooling systems have gained increased attention these last years, for its potential to lower indoor temperatures using renewable energy. However, architectural integration of these systems in buildings has not been fully explored. Current developments such as small scale solar driven heat pumps and solar cooling kits commercially available...journal article 2017
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Prieto Hoces, A.I. (author), Klein, T. (author), Knaack, U. (author), Auer, Thomas (author)The integration of decentralised building services into façade components presents advantages from functional and constructional standpoints. However, this integrated approach has not been massively implemented, having only stand-alone buildings and façade concepts as examples. This paper seeks to identify the main perceived problems at...journal article 2017