Safety regulation: The lessons of workplace safety rule management for managing the regulatory burden

There is a strong political consensus in a number of countries that occupational safety and health regulation is stifling industrial innovation and development and is feeding a culture of damaging risk aversion and petty bureaucracy. In a number of countries this has led to proposals to repeal regulations and reduce the regulatory burden. The...

Computational identification of insertional mutagenesis targets for cancer gene discovery

Insertional mutagenesis is a potent forward genetic screening technique used to identify candidate cancer genes in mouse model systems. An important, yet unresolved issue in the analysis of these screens, is the identification of the genes affected by the insertions. To address this, we developed Kernel Convolved Rule Based Mapping (KC-RBM). KC...

Somatic structural rearrangements in genetically engineered mouse mammary tumors

Background: Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E...

Identification of Networks of Co-Occurring, Tumor-Related DNA Copy Number Changes Using a Genome-Wide Scoring Approach

Tumorigenesis is a multi-step process in which normal cells transform into malignant tumors following the accumulation of genetic mutations that enable them to evade the growth control checkpoints that would normally suppress their growth or result in apoptosis. It is therefore important to identify those combinations of mutations that...

Capacity Reductions at Incidents Sites on Motorways

Incidents cause a large part of the delays in road networks. This is caused by a decrease of the capacity at the incident site. A detailed knowledge of the queue discharge rate can improve for instance the traffic prediction and thereby improve delay information or routing advice. Therefore, this study determines the queue discharge rate for...

Using Aspect Orientation in Legacy Environments for Reverse Engineering using Dynamic Analysis: An Industrial Experience Report

Preprint of article published in: Journal of Systems and Software (Elsevier), 82 (4), 2009; doi:10.1016/j.jss.2008.09.031 This paper reports on the challenges of using aspect-oriented programming (AOP) to aid in re-engineering a legacy C application. More specifically, we describe how AOP helps in the important reverse engineering step which...

ALMD: A modeling environment for ILES

Further development of Large Eddy Simulation faces as major obstacle the strong coupling between subgrid-scale model and the truncation error of the numerical discretization. Recent analyzes indicate that for certain discretizations and certain flow configurations the truncation error itself can act as implicit SGS model. Relevant...

Spin structure of the proton from polarized inclusive deep-inelastic muon-proton scattering

Energetics and kinetics of maltose transport in Saccharomyces cerevisiae: A continuous culture study

International Conference on Physical Modeling of Transport and Dispersion

Proceedings of the 4th conference organized by IAHR (section on experimental methods and physical modeling) on scale effects. Special keynotes and invited presentations describe the contributions of Dr. Keulegan and their relation to present work in mixing processes, stratified flow and other areas of fluid mechanics. These proceedings contain...

Netwerken in de elektrotechniek

The influence of gas streams and magnetic fields on electric discharges part 3: arcs in transverse magnetic fields at atmospheric pressure

Experimental results in air at a pressure of one atmosphere on the behaviour of arcs under the action of applied magnetic fields are given for two electrode materials (graphite and brass) and different electrode configurations. These results extend earlier work, in annular gaps using graphite, to larger electrode path lengths on graphite and...

The influence of gas streams and magnetic fields on electric discharges: Part 2. The shape of an arc rotating round an annular gap

The shape of the column of a d.c. electric arc rotating in an annular gap between carbon electrodes is derived using a simple model for the arc, which is based on the concept of a solid conductor with uniform current density in a transverse uniform magnetic field and an opposing uniform flow field. It is shown that the shape for steady rotation...

The influence of gas streams and magnetic fields on electric discharges: Part I. Arcs at atmospheric pressure in annular gaps

This Note describes an experiment al study of the motion and electric properties of a d.c. arc moving round an annular gap under the action of a magnetic field. The dependence of the motion on the arc current, magnetic field and gap width is given for values up to 750 ampss, 940 gauss and 3.2 cm respectively. The electrical characteristics of a...

On the synthesis of three-terminal networks composed of the two kinds of elements

On the synthesis of 3-terminal RC networks

This report is concerned with the synthesis of 3-terminal RC networks according to three specified network functions. Some necessary conditions for physical real-izability are derived from first principles by an algebraic method. The possibility of synthesis is shown to depend upon a certain inequality but the weakest conditions required in...