Single-cell reference mapping to construct and extend cell-type hierarchies

Single-cell genomics is now producing an ever-increasing amount of datasets that, when integrated, could provide large-scale reference atlases of tissue in health and disease. Such large-scale atlases increase the scale and generalizability of analyses and enable combining knowledge generated by individual studies. Specifically, individual...

Predicting Metabolic Adaptation Under Dynamic Substrate Conditions Using a Resource-Dependent Kinetic Model: A Case Study Using Saccharomyces cerevisiae

Exposed to changes in their environment, microorganisms will adapt their phenotype, including metabolism, to ensure survival. To understand the adaptation principles, resource allocation-based approaches were successfully applied to predict an optimal proteome allocation under (quasi) steady-state conditions. Nevertheless, for a general,...

Influence of oxygen concentration on the metabolism of Penicillium chrysogenum

In large-scale bioreactors, there is often insufficient mixing and as a consequence, cells experience uneven substrate and oxygen levels that influence product formation. In this study, the influence of dissolved oxygen (DO) gradients on the primary and secondary metabolism of a high producing industrial strain of Penicillium chrysogenum was...

Preliminary results from a field experiment on e-bike safety: Speed choice and mental workload for middle-aged and elderly cyclists

To study the safety of e-bikes for the elderly, an experimental field study was conducted, using instrumented bicycles and comparing two age groups: older cyclists, n= 29, mean age = 70, SD = 4.2 and middle-aged cyclists, n = 29, mean age = 38, SD = 4.3. All were regular cyclists. They rode a fixed route with a length of about 3.5 km: once on an...

Design and implementation of a new algorithm simulating the deformation of fabric reinforced plastics

Approximatietheorie in Delft

Exact en niet exact in de wiskunde

Over differentievergelijkingen