⁸⁹Zr-Trastuzumab PET/CT Imaging of HER2-Positive Breast Cancer for Predicting Pathological Complete Response after Neoadjuvant Systemic Therapy: A Feasibility Study

Background: Approximately 20% of invasive ductal breast malignancies are human epidermal growth factor receptor 2 (HER2)-positive. These patients receive neoadjuvant systemic therapy (NAT) including HER2-targeting therapies. Up to 65% of patients achieve a pathological complete response (pCR). These patients might not have needed surgery....

Navigating multiple contexts to integrate system transformation programs

This paper unpacks how actors navigate the multiple organizational, interorganizational and industry contexts that are associated with system transformation programs for addressing wicked, societal problems. Because system transformation programs can only succeed when changes are implemented by multiple organizations, an increased...

Innovating across boundaries; a process study on digital innovation

Tapping into past design experiences: Knowledge sharing and creation during novice-expert design consultations

Designing is a knowledge-intensive activity. For novice design engineers, an important means of acquiring knowledge is to consult experienced colleagues. We observed novice–expert consultations as part of three engineering projects in a large aerospace company. Seven meetings were analysed in detail regarding the design activity, the content,...

Novice-Expert Design Consultations: Findings from a Field Study

This study aimed to investigate the process of novice-expert consultation meetings in an organizational context by identifying phases of the discourse and analysing the nature of these phases. An empirical study was performed at Rolls-Royce Aerospace Engineering by capturing 7 audio-records of meetings between trainees (novices) and expert...

Novice–expert consultations as a vehicle for organizational learning - a field study in engineering product development

Product development is a knowledge intensive activity and organizational learning across projects and functions is vital for its success. This paper explores novice–expert consultations as a vehicle of social learning through a detailed analysis of meetings during an engineering training programme. Although the meetings were initiated for the...