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Rudnik‐Jansen, Imke (author), Tellegen, Anna R. (author), Pouran, B. (author), Schrijver, Karin (author), Meij, Björn P. (author), Emans, Pieter J. (author), de Gendt, Erin (author), Thomas, Rachel E. (author), Kik, Marja J.L. (author), de Visser, Huub M. (author), Weinans, Harrie (author), Egas, Annelies (author), van Maarseveen, Erik (author), Woike, Nina (author), Mihov, George (author), Thies, Jens (author), Tryfonidou, Marianna A. (author), Creemers, Laura B. (author)Background and Purpose: Corticosteroids are intra-articularly injected to relieve pain in joints with osteoarthritis (OA) or acute tissue damage such as ligament or tendon tears, despite its unverified contraindication in unstable joints. Biomaterial-based sustained delivery may prolong reduction of inflammatory pain, while avoiding harmful...journal article 2019
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Croes, M. (author), Kruyt, M. C. (author), Boot, W. (author), Pouran, B. (author), Braham, M. V. (author), Pakpahan, S.A. (author), Weinans, Harrie (author), Vogely, H.C. (author), Fluit, A.C. (author), Dhert, W.J. (author), Alblas, J. (author), Öner, F.C. (author)Immune cells and their soluble factors regulate skeletal cells during normal bone regeneration and pathological bone formation. Bacterial infections can trigger immune responses that activate pro-osteogenic pathways, but these are usually overshadowed by osteolysis and concerns of systemic inflammation. The aim of this study was to determine...journal article 2019
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Koolen, Marianne K.E. (author), Kruyt, Moyo C. (author), Öner, Fetullah C. (author), Schaden, Wolfgang (author), Weinans, Harrie (author), van der Jagt, Olav P. (author)Summary: Extracorporeal shockwave therapy showed a pronounced effect on bone mass in previous animal studies. We showed in this pilot study that a single treatment with unfocused shockwave therapy in unselected patients does not show side effects. Although our study did not show any effect of shockwave on BMD, the limited sample size does not...journal article 2019
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Snijders, T.E. (author), Schlösser, Tom P.C. (author), van Gaalen, S.M. (author), Castelein, R.M. (author), Weinans, Harrie (author), de Gast, A. (author)Background: Acetabular cup orientation plays a key role in implant stability and the success of total hip arthroplasty. To date, the orientation has been measured with different imaging modalities and definitions, leading to lack of consensus on optimal cup placement. A 3-dimensional (3D) concept involving a trigonometric description enables...journal article 2018
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Rahnamay Moshtagh, P. (author), Korthagen, Nicoline M. (author), Plomp, Saskia G. (author), Pouran, B. (author), Castelein, Rene M. (author), Zadpoor, A.A. (author), Weinans, Harrie (author)This study aims to investigate the earliest alterations of bone and cartilage tissues as a result of different exercise protocols in the knee joint of Wistar rats. We hypothesize that pretraining to a continuous intense running protocol would protect the animals from cartilage degeneration. Three groups of animals were used: (i) an adaptive ...journal article 2018
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Kolken, H.M.A. (author), Janbaz, S. (author), Leeflang, M.A. (author), Lietaert, K. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Rationally designed meta-biomaterials present unprecedented combinations of mechanical, mass transport, and biological properties favorable for tissue regeneration. Here we introduce hybrid meta-biomaterials with rationally-distributed values of negative (auxetic) and positive Poisson’s ratios, and use them to design meta-implants that unlike...journal article 2018
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Li, Y. (author), Jahr, H. (author), Lietaert, K. (author), Pavanram, P. (author), Yilmaz, A. (author), Fockaert, L.I. (author), Leeflang, M.A. (author), Pouran, B. (author), Gonzalez Garcia, Y. (author), Weinans, Harrie (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most...journal article 2018
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Pouran, B. (author), Moshtagh, Parisa R. (author), Arbabi, V. (author), Snabel, Jessica (author), Stoop, Reinout (author), Ruberti, Jeffrey (author), Malda, Jos (author), Zadpoor, A.A. (author), Weinans, Harrie (author)An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether...journal article 2018
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de Visser, H.M. (author), Mastbergen, S. C. (author), Ravipati, S. (author), Welsing, P. M.J. (author), Pinto, F.C. (author), Lafeber, F.P.J.G. (author), Chapman, V. (author), Barrett, D. A. (author), Weinans, Harrie (author)Objective Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally...journal article 2018
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Ahmadi, S.M. (author), Hedayati, R. (author), Li, Y (author), Lietaert, K. (author), Tümer, N. (author), Fatemi, A. (author), Rans, C.D. (author), Pouran, B. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is, however, not clear to what extent the material type...journal article 2018
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de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...journal article 2018
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Koolen, Marianne K.E. (author), Pouran, B. (author), Oner, Fetullah C. (author), Zadpoor, A.A. (author), van der Jagt, Olav P. (author), Weinans, Harrie (author)Bone substitutes are frequently used in clinical practice but often exhibit limited osteoinductivity. We hypothesized that unfocused shockwaves enhance the osteoinductivity of bone substitutes and improve osteointegration and angiogenesis. Three different bone substitutes, namely porous tricalcium phosphate, porous hydroxyapatite and porous...journal article 2018
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Croes, M. (author), de Visser, H. (author), Meij, B. P. (author), Lietart, K. (author), van der Wal, B. C.H. (author), Vogely, H. C. (author), Fluit, A. C. (author), Boel, C. H.E. (author), Alblas, J. (author), Weinans, Harrie (author), Amin Yavari, S. (author)A model is needed to study the effectiveness of different anti-bacterial coatings on complex metal implants in a bone environment. This article shares data on the design of porous titanium implants for intramedullary implantation in the proximal rat tibia. The implant length, diameter and porosity were optimized after testing on cadaveric...journal article 2018
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Kuperus, J.S. (author), Smit, E.J.M. (author), Pouran, B. (author), van Hamersvelt, R.W. (author), van Stralen, Marijn (author), Seevinck, P.R. (author), Buckens, C.F. (author), Bleys, Ronald L.A.W. (author), Weinans, Harrie (author), Oner, F. C. (author), de Jong, P.A. (author), Verlaan, J-J (author)Diffuse idiopathic skeletal hyperostosis (DISH) is often theorized to be an ossification of the anterior longitudinal ligament (ALL). Using computed tomography (CT) imaging and cryomacrotome sectioning, we investigated the spatial relationship between the ALL and newly formed bone in DISH to test this hypothesis. In the current study, four...journal article 2018
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Mirzaali, Mohammad J. (author), Van Dongen, I. C.P. (author), Tümer, N. (author), Weinans, Harrie (author), Amin Yavari, S. (author), Zadpoor, A.A. (author)Nanopillar arrays that are bactericidal but not cytotoxic against the host cells could be used in implantable medical devices to prevent implant-associated infections. It is, however, unclear what heights, widths, interspacing, and shape should be used for the nanopillars to achieve the desired antibacterial effects while not hampering the...journal article 2018
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Mirahmadi, F. (author), Koolstra, J. H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G. H. (author), Snabel, J. (author), Stoop, R. (author), Arbabi, V. (author), Weinans, Harrie (author), Everts, V. (author)Objective: Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical...journal article 2018
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Longoni, A. (author), Knežević, L. (author), Schepers, K. (author), Weinans, Harrie (author), Rosenberg, A.J.W.P. (author), Gawlitta, D. (author)Tissue engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. Such constructs typically consist of multipotent mesenchymal stromal cells (MSCs) forming a cartilage template in vitro, which can be implanted to stimulate bone formation in vivo. The use of...journal article 2018
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Aleksinskaya, Marina A. (author), Monge, Matthieu (author), Siebelt, Michiel (author), Slot, Edith M. (author), Koekkoek, Karin M. (author), de Bruin, Ruben G. (author), Massy, Ziad A. (author), Weinans, Harrie (author), Rabelink, Ton J. (author), Fibbe, Willem E. (author), Jan van Zonneveld, Anton (author), van Pel, Melissa (author)In chronic kidney disease (CKD), endothelial injury, is associated with disease progression and an increased risk for cardiovascular complications. Circulating cells with vascular reparative functions are hematopoietic and also reduced in CKD. To explore the mechanistic basis behind these observations, we have investigated hematopoietic stem...journal article 2018
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Kamperman, T. (author), Henke, S. (author), Zoetebier, B. (author), Ruiterkamp, N. (author), Wang, R. (author), Pouran, B. (author), Weinans, Harrie (author), Karperien, M. (author), Leijten, J (author)In situ gelation of water-in-oil polymer emulsions is a key method to produce hydrogel particles. Although this approach is in principle ideal for encapsulating bioactive components such as cells, the oil phase can interfere with straightforward presentation of crosslinker molecules. Several approaches have been developed to induce in-emulsion...journal article 2017
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Bobbert, F.S.L. (author), Lietaert, K. (author), Eftekhari, A.A. (author), Pouran, B. (author), Ahmadi, S.M. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Porous biomaterials that simultaneously mimic the topological, mechanical, and mass transport properties of bone are in great demand but are rarely found in the literature. In this study, we rationally designed and additively manufactured (AM) porous metallic biomaterials based on four different types of triply periodic minimal surfaces (TPMS)...journal article 2017