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Coupling extracellular glycan composition with metagenomic data in papermill and brewery anaerobic granular sludges

Doloman, Anna (author), de Bruin, S. (author), van Loosdrecht, Mark C.M. (author), Sousa, Diana Z. (author), Lin, Y. (author)

Glycans are crucial for the structure and function of anaerobic granular sludge in wastewater treatment. Yet, there is limited knowledge regarding the microorganisms and biosynthesis pathways responsible for glycan production. In this study, we analysed samples from anaerobic granular sludges treating papermill and brewery wastewater,...

journal article 2024

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Pre-transplant kidney quality evaluation using photoacoustic imaging during normothermic machine perfusion

Nikolaev, Anton V. (author), Fang, Yitian (author), Essers, Jeroen (author), Panth, Kranthi M. (author), Ambagtsheer, Gisela (author), Clahsen-van Groningen, Marian C. (author), Minnee, Robert C. (author), van Soest, G. (author), de Bruin, Ron W.F. (author)

Due to the shortage of kidneys donated for transplantation, surgeons are forced to use the organs with an elevated risk of poor function or even failure. Although the existing methods for pre-transplant quality evaluation have been validated over decades in population cohort studies across the world, new methods are needed as long as delayed...

journal article 2024

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Evaluation of recursive Bayesian filters for modal contribution estimation in high-tech compliant mechanisms

de Bruin, P. E. (author), Kaczmarek, M.B. (author), Kok, M. (author), Hassan HosseinNia, S. (author)

This study evaluates three recursive Bayesian input and state estimation algorithms, as introduced in the field of Structural Health Monitoring, for estimating modal contributions for high-tech compliant mechanisms. The aim of estimating modal contributions is the use for active vibration control. High-tech compliant motion stages allow for...

journal article 2023

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Creating Conjugated C−C Bonds between Commercial Carbon Electrode and Molecular Catalyst for Oxygen Reduction to Hydrogen Peroxide

Biemolt, J. (author), Meeus, Eva J. (author), de Zwart, Felix J. (author), de Graaf, Jeen (author), Laan, Petrus C.M. (author), de Bruin, Bas (author), Burdyny, T.E. (author), Rothenberg, Gadi (author), Yan, Ning (author)

Immobilizing molecular catalysts on electrodes is vital for electrochemical applications. However, creating robust electrode-catalyst interactions while maintaining good catalytic performance and rapid electron transfer is challenging. Here, without introducing any foreign elements, we show a bottom-up synthetic approach of constructing the...

journal article 2023

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Real-time laser speckle contrast imaging measurement during normothermic machine perfusion in pretransplant kidney assessment

Fang, Yitian (author), van Ooijen, Lisanne (author), Ambagtsheer, Gisela (author), Nikolaev, Anton V. (author), Clahsen-van Groningen, Marian C. (author), Dankelman, J. (author), de Bruin, Ron W.F. (author), Minnee, Robert C. (author)

Objectives: Normothermic machine perfusion (NMP) provides a platform for pre-transplant kidney quality assessment that is essential for the use of marginal donor kidneys. Laser speckle contrast imaging (LSCI) presents distinct advantages as a real-time and noncontact imaging technique for measuring microcirculation. In this study, we aimed to...

journal article 2023

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Sialylation and Sulfation of Anionic Glycoconjugates Are Common in the Extracellular Polymeric Substances of Both Aerobic and Anaerobic Granular Sludges

Chen, L.M. (author), de Bruin, S. (author), Pronk, M. (author), Sousa, Diana Z. (author), van Loosdrecht, Mark C.M. (author), Lin, Y. (author)

Anaerobic and aerobic granular sludge processes are widely applied in wastewater treatment. In these systems, microorganisms grow in dense aggregates due to the production of extracellular polymeric substances (EPS). This study investigates the sialylation and sulfation of anionic glyconconjugates in anaerobic and aerobic granular sludges...

journal article 2023

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Redundancy and the role of protein copy numbers in the cell polarization machinery of budding yeast

Brauns, Fridtjof (author), Iñigo de la Cruz, L.M. (author), Daalman, W.K. (author), de Bruin, Ilse (author), Halatek, Jacob (author), Laan, L. (author), Frey, Erwin (author)

How can a self-organized cellular function evolve, adapt to perturbations, and acquire new sub-functions? To make progress in answering these basic questions of evolutionary cell biology, we analyze, as a concrete example, the cell polarity machinery of Saccharomyces cerevisiae. This cellular module exhibits an intriguing resilience: it...

journal article 2023

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Computational mechanistic studies of ruthenium catalysed methanol dehydrogenation

de Zwart, Felix J. (author), Sinha, V. (author), Trincado, Monica (author), Grützmacher, Hansjörg (author), de Bruin, Bas (author)

Homogeneous ruthenium catalysed methanol dehydrogenation could become a key reaction for hydrogen production in liquid fuel cells. In order to improve existing catalytic systems, mechanistic insight is paramount in directing future studies. Herein, we describe what computational mechanistic research has taught us so far about ruthenium...

journal article 2022

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Stepping into the shoes of the policy maker: Results of a Participatory Value Evaluation for the Dutch long term COVID-19 strategy

Mouter, N. (author), Jara, Karen Trujillo (author), Hernández, J.I. (author), Kroesen, M. (author), de Vries, M.O. (author), Geijsen, Tom (author), Kroese, Floor (author), Uiters, Ellen (author), de Bruin, Marijn (author)

Background: The COVID-19 outbreak early 2020 was followed by an unprecedented package of measures. The relative calmness of the pandemic early 2022 provides a momentum to prepare for various scenarios. Objectives: As acceptance of COVID-19 measures is key for public support we investigated citizens’ preferences towards imposing measures in four...

journal article 2022

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How Culture Influences Individual Behavior During a Pandemic: A Social Simulation of the COVID-19 Crisis

Kreulen, Kurt (author), de Bruin, B. (author), Ghorbani, Amineh (author), Mellema, René (author), Kammler, Christian (author), Vanhee, Loïs (author), Dignum, Frank (author), Dignum, Virginia (author)

Since its first appearance in Wuhan (China), countries have been employing, to varying degrees of success, a series of non-pharmaceutical interventions aimed at limiting the spread of SARS-CoV-2 within their populations. In this article, we build on scientific work that demonstrates that culture is part of the explanation for the observed...

journal article 2022

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The Role of Vacancies in a Ti₂CT_x MXene-Derived Catalyst for Butane Oxidative Dehydrogenation

Ronda-Lloret, M. (author), Slot, T. K. (author), van Leest, N. P. (author), de Bruin, B. (author), Sloof, W.G. (author), Batyrev, E. (author), Sepúlveda-Escribano, A. (author), Ramos-Fernandez, E. V. (author), Rothenberg, G. (author), Shiju, N. R. (author)

MXenes are a new family of 2D carbides or nitrides that have attracted attention due to their layered structure, tunable surface groups and high electrical conductivity. Here, we report for the first time that the Ti₂CT_x MXene catalyses the selective oxidative dehydrogenation of n-butane to butenes and 1,3-butadiene....

journal article 2022

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Sulfated glycosaminoglycan-like polymers are present in an acidophilic biofilm from a sulfidic cave

de Bruin, S. (author), Vasquez Cardenas, D. (author), Sarbu, S. M. (author), Meysman, F.J.R. (author), Sousa, D. Z. (author), van Loosdrecht, Mark C.M. (author), Lin, Y. (author)

Sulfated glycosaminoglycans (sGAG) are negatively charged extracellular polymeric substances that occur in biofilms from various environments. Yet, it remains unclear whether these polymers are acquired from the external environment or produced by microbes in the biofilm. To resolve this, we analyzed the presence of sGAGs in samples of an...

journal article 2022

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School Furniture and Anthropometric Fit, the Gap Between Theory and Practice

de Bruin, R. (author), Castellucci, Héctor I. (author)

The chairs' editorial for the theme track 'Sound and Design'

journal article 2022

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Quantitative assessment of impact and sensitivity of imaging spectroscopy for monitoring of ageing of archival documents

Padoan, R. (author), Klein, Marvin E. (author), Groves, R.M. (author), de Bruin, Gerrit (author), Steemers, Ted A.G. (author), Strlič, Matija (author)

Ageing of historical documents often results in changes in the optical properties of the constituent materials. Imaging spectroscopy (IS) can be a valuable tool for monitoring of such changes, if the method fulfils two important conditions. Firstly, compared to natural ageing, the accumulated light dose from repeated measurements of the...

journal article 2021

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Nitrogen Oxide Emissions from U.S. Oil and Gas Production: Recent Trends and Source Attribution

Dix, Barbara (author), de Bruin, Joep (author), Roosenbrand, E.J. (author), Vlemmix, T. (author), Francoeur, Colby (author), Gorchov-Negron, Alan (author), McDonald, Brian (author), Zhizhin, Mikhail (author), Elvidge, Christopher (author), Veefkind, j. Pepijn (author), Levelt, Pieternel Felicitas (author), de Gouw, Joost (author)

U.S. oil and natural gas production volumes have grown by up to 100% in key production areas between January 2017 and August 2019. Here we show that recent trends are visible from space and can be attributed to drilling, production, and gas flaring activities. By using oil and gas activity data as predictors in a multivariate regression to...

journal article 2020

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Fine-tuning deep RL with gradient-free optimization

de Bruin, T.D. (author), Kober, J. (author), Tuyls, Karl (author), Babuska, R. (author)

Deep reinforcement learning makes it possible to train control policies that map high-dimensional observations to actions. These methods typically use gradient-based optimization techniques to enable relatively efficient learning, but are notoriously sensitive to hyperparameter choices and do not have good convergence properties. Gradient...

journal article 2020

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Interactions between cyclists and automated vehicles: Results of a photo experiment*

Hagenzieker, Marjan (author), van der Kint, Sander (author), Vissers, Luuk (author), van Schagen, Ingrid N.L.G. (author), de Bruin, Jonathan (author), van Gent, P. (author), Commandeur, Jacques J.F. (author)

Cyclists may have incorrect expectations of the behaviour of automated vehicles in interactions with them, which could bring extra risks in traffic. This study investigated whether expectations and behavioural intentions of cyclists when interacting with automated cars differed from those with manually driven cars. A photo experiment was...

journal article 2019

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Integrating state representation learning into deep reinforcement learning

de Bruin, T.D. (author), Kober, J. (author), Tuyls, K.P. (author), Babuska, R. (author)

Most deep reinforcement learning techniques are unsuitable for robotics, as they require too much interaction time to learn useful, general control policies. This problem can be largely attributed to the fact that a state representation needs to be learned as a part of learning control policies, which can only be done through fitting expected...

journal article 2018

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Experience selection in deep reinforcement learning for control

de Bruin, T.D. (author), Kober, J. (author), Tuyls, K.P. (author), Babuska, R. (author)

Experience replay is a technique that allows off-policy reinforcement-learning methods to reuse past experiences. The stability and speed of convergence of reinforcement learning, as well as the eventual performance of the learned policy, are strongly dependent on the experiences being replayed. Which experiences are replayed depends on two...

journal article 2018

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Chronic kidney failure mineral bone disorder leads to a permanent loss of hematopoietic stem cells through dysfunction of the stem cell niche

Aleksinskaya, Marina A. (author), Monge, Matthieu (author), Siebelt, Michiel (author), Slot, Edith M. (author), Koekkoek, Karin M. (author), de Bruin, Ruben G. (author), Massy, Ziad A. (author), Weinans, Harrie (author), Rabelink, Ton J. (author), Fibbe, Willem E. (author), Jan van Zonneveld, Anton (author), van Pel, Melissa (author)

In chronic kidney disease (CKD), endothelial injury, is associated with disease progression and an increased risk for cardiovascular complications. Circulating cells with vascular reparative functions are hematopoietic and also reduced in CKD. To explore the mechanistic basis behind these observations, we have investigated hematopoietic stem...

journal article 2018