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Wiegmans, B. (author), Mouter, N. (author), Vanelslander, Thierry (author), Verweij, Stefan (author)The cost-benefit analysis (CBA) is a widely used approach for the appraisal of transport projects, but criticisms on it have led to the development of alternatives such as the BENEFIT approach. This book chapter analyzes three cases of infrastructure investments in port areas in Belgium and the Netherlands, by application of the BENEFIT approach...book chapter 2022
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Guo, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)This article presents a compact analog front-end (AFE) circuit for ultrasound receivers with linear-in-dB continuous gain control for time-gain compensation (TGC). The AFE consists of two variable-gain stages, both of which employ a novel complementary current-steering network (CCSN) as the interpolator to realize continuously variable gain....journal article 2022
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Hakakzadeh, Soheil (author), Mozaffarzadeh, M. (author), Mostafavi, S.. (author), Kavehvash, Zahra (author), Rajendran, Praveenbalaji (author), Verweij, M.D. (author), de Jong, N. (author), Pramanik, Manojit (author)In photoacoustic tomography (PAT) systems, the tangential resolution decreases due to the finite size of the transducer as the off-center distance increases. To address this problem, we propose a multi-angle detection approach in which the transducer used for data acquisition rotates around its center (with specific angles) as well as around...journal article 2022
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Spiekhout, Sander (author), Voorneveld, J.D. (author), Van Elburg, Benjamin (author), Renaud, G.G.J. (author), Segers, Tim (author), Lajoinie, Guillaume P.R. (author), Versluis, Michel (author), Verweij, M.D. (author), de Jong, N. (author), Bosch, Johannes G. (author)Ultrasound (US) contrast agents consist of microbubbles ranging from 1 to 10 μm in size. The acoustical response of individual microbubbles can be studied with high-frame-rate optics or an "acoustical camera"(AC). The AC measures the relative microbubble oscillation while the optical camera measures the absolute oscillation. In this article,...journal article 2022
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Kim, Taehoon (author), Fool, F. (author), Simoes dos Santos, D. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) directly integrated with an array of 12 × 80 piezoelectric transducer elements to enable next-generation ultrasound probes for 3D carotid artery imaging. The ASIC, implemented in a 0.18 µm high-voltage Bipolar-CMOS-DMOS (HV BCD) process, adopted a...journal article 2021
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Mozaffarzadeh, M. (author), Verweij, M.D. (author), Daeichin, V. (author), de Jong, N. (author), Renaud, G.G.J. (author)Transcranial ultrasound imaging is a suitable technology for diagnosis of strokes as it is safe, portable, relatively inexpensive and available in emergency medicine services, however it currently offers poor image quality due to the phase aberration caused by the human skull. In this work, we evaluate an approach for two-dimensional...conference paper 2021
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Hakakzadeh, Soheil (author), Mozaffarzadeh, M. (author), Mostafavi, Seyed Masood (author), Amjadian, Mohammadreza (author), Kavehvash, Zahra (author), Verweij, M.D. (author), de Jong, N. (author)In circular photoacoustic computed tomography, for data acquisition, a single-element transducer rotates around the region of interest (ROI). Due to the limited acceptance angle of the finite size transducer, the reconstructed image becomes blurred, and tangential resolution/contrast degrades in off-center locations in the ROI. In this paper, we...conference paper 2021
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Simoes dos Santos, D. (author), Fool, F. (author), Kim, Taehoon (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)Over the past decades, real-time three-dimensional (3D) medical ultrasound has attracted much attention since it enables clinicians to diagnose more accurately. This calls for ultrasound matrix transducers with a large number of elements, which can be interfaced with an application-specific integrated circuit (ASIC) for data reduction. An...conference paper 2021
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Collado Lara, G. (author), Heymans, Sophie V. (author), Rovituso, M. (author), Carlier, Bram (author), Toumia, Yosra (author), Verweij, M.D. (author), Vos, H.J. (author), de Jong, N. (author), Daeichin, V. (author)The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous...journal article 2021
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van Willigen, D.M. (author), Kang, E. (author), Janjic, Jovana (author), Noothout, E.C. (author), Chang, Z.Y. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This article presents an application-specific integrated circuit (ASIC) designed for intra-vascular ultrasound imaging that interfaces 64 piezoelectric transducer elements to an imaging system using a single micro-coaxial cable. Thus, it allows a single-element transducer to be replaced by a transducer array to enable 3-D imaging. The 1.5-mm...journal article 2021
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), Sabbadini, A. (author), de Jong, N. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author)Current ultrasonic clamp-on flow meters consist of a pair of single-element transducers that are carefully positioned before use. This positioning process consists of manually finding the distance between the transducer elements, along the pipe axis, for which maximum signal-to-noise ratio (SNR) is achieved. This distance depends on the sound...journal article 2021
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), de Jong, N. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author)Acoustic wave propagation in ultrasonic flow measurements is typically assumed to be linear and reciprocal. However, if the transmitting transducer generates a sufficiently high pressure, nonlinear wave propagation effects become significant. In flow measurements, this would translate into more information to estimate the flow and therefore a...journal article 2021
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Wei, Luxi (author), Wahyulaksana, G. (author), Meijlink, Bram (author), Ramalli, Alessandro (author), Noothout, E.C. (author), Verweij, M.D. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Vos, H.J. (author)Volumetric ultrasound imaging of blood flow with microbubbles enables a more complete visualization of the microvasculature. Sparse arrays are ideal candidates to perform volumetric imaging at reduced manufacturing complexity and cable count. However, due to the small number of transducer elements, sparse arrays often come with high clutter...journal article 2021
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Mozaffarzadeh, M. (author), Moore, Colman (author), Golmoghani, Erfan Barzegar (author), Mantri, Yash (author), Hariri, Ali (author), Jorns, Alec (author), Fu, Lei (author), Verweij, M.D. (author), de Jong, N. (author)Simultaneous visualization of the teeth and periodontium is of significant clinical interest for image-based monitoring of periodontal health. We recently reported the application of a dual-modality photoacoustic-ultrasound (PA-US) imaging system for resolving periodontal anatomy and periodontal pocket depths in humans. This work utilized a...journal article 2021
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Waasdorp, R. (author), Mugge, W. (author), Vos, H.J. (author), De Groot, Jurriaan H. (author), Verweij, M.D. (author), de Jong, N. (author), Schouten, A.C. (author), Daeichin, V. (author)Skeletal muscles generate force, enabling movement through a series of fast electro-mechanical activations coordinated by the central nervous system. Understanding the underlying mechanism of such fast muscle dynamics is essential in neuromuscular diagnostics, rehabilitation medicine and sports biomechanics. The unique combination of...journal article 2021
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Sabbadini, A. (author), Caenen, A.F.M. (author), Keijzer, L.B.H. (author), van Neer, P.L.M.J. (author), Vos, H.J. (author), de Jong, N. (author), Verweij, M.D. (author)Shear wave elastography (SWE) has the potential to determine cardiac tissue stiffness from non-invasive shear wave speed measurements, important, e.g., for predicting heart failure. Previous studies showed that waves traveling in the interventricular septum (IVS) may display Lamb-like dispersive behaviour, introducing a thickness-frequency...journal article 2021
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Beekers, D.I. (author), Vegter, Merel (author), Lattwein, Kirby R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)Ultrasound insonification of microbubbles can locally increase vascular permeability to enhance drug delivery. To control and optimize the therapeutic potential, we need to better understand the underlying biological mechanisms of the drug delivery pathways. The aim of this in vitro study was to elucidate the microbubble-endothelial cell...journal article 2020
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), Willigen, D. M. van (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)During ultrasonic clamp-on flow metering, Lamb waves propagating in the pipe wall may limit the measurement accuracy by introducing absolute errors in the flow estimates. Upon reception, these waves can interfere with the up and downstream waves refracting from the liquid, and disturb the measurement of the transit time difference that is used...journal article 2020
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Mozaffarzadeh, M. (author), Minonzio, C.G. (author), de Jong, N. (author), Verweij, M.D. (author), Hemm, Simone (author), Daeichin, V. (author)Phase aberration in transcranial ultrasound imaging (TUI) caused by the human skull leads to an inaccurate image reconstruction. In this article, we present a novel method for estimating the speed of sound and an adaptive beamforming technique for phase aberration correction in a flat polyvinylchloride (PVC) slab as a model for the human...journal article 2020
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Massaad Mouawad, J.M. (author), van Neer, P.L.M.J. (author), van Willigen, D.M. (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)Current ultrasonic clamp-on flow meters are manually calibrated. This process is based on manual placement of two single-element transducers along a pipe wall. Due to the usually unknown pipe properties and inhomogeneities in the pipe geometry, the axial distance of the transducers needs to be manually calibrated to align the location of the...journal article 2020