SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer's disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer's disease, and SORL1 variants increase risk for late-onset AD. To understand the contribution of SORL1 mutations to AD pathogenesis,...

Hydrodynamic Forces on Ships in Dredged Channels

An extension of two-dimensional sail theory

Ship motions in shallow water

Ship Motions and Sea Loads

Sinkage and trim in shallow water of finite width

Shallow water flows past slender bodies