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Wever, Mark (author), Romera, Alvaro (author), Shah, Munir (author), Wognum, Nel (author)Researchers are increasingly working in large, integrated science programmes. This is supposed to lead to several benefits, including creating and enhancing synergies amongst projects, improving collaboration and knowledge exchanges amongst researchers from different disciplines, and generating a higher return on investments in R&D. In...journal article 2023
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Chen, Shaohang (author), Zhang, Jiaan (author), Zeng, Zhigang (author), Dai, Zongjie (author), Wang, Qinhong (author), Wever, Ron (author), Hollmann, F. (author), Zhang, W. (author)A chemoenzymatic method for the synthesis of haloethers is presented. A combination of enzymatic hypohalite synthesis with spontaneous oxidation of alkenes and nucleophilic attack by various alcohols enabled the synthesis of a wide range of haloethers. The reaction system has been characterised and current imitations have been worked out. In...journal article 2022
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Wever, Mark (author), Romera, Alvaro (author), Wognum, Nel (author), Shah, Munir (author)To solve complex problems, researchers are increasingly working in large, integrated research programmes. Integration of projects within a single programme rather than supporting a range of individual, more autonomous projects, is supposed to lead to several benefits, including: creating and enhancing synergies amongst projects, improving...conference paper 2022
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Li, Huanhuan (author), Younes, S.H.H. (author), Chen, Shaohang (author), Duan, Peigao (author), Cui, Chengsen (author), Wever, Ron (author), Zhang, Wuyuan (author), Hollmann, F. (author)In this contribution, we report chemoenzymatic bromodecarboxylation (Hunsdiecker-type) of α,ß-unsaturated carboxylic acids. The extraordinarily robust chloroperoxidase from Curvularia inaequalis (CiVCPO) generated hypobromite from H2O2 and bromide, which then spontaneously reacted with a broad range of unsaturated carboxylic acids and yielded...journal article 2022
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Wever, Mark (author), Shah, Munir (author), Wognum, Nel (author), Sharifi, Mostafa (author), O'Leary, Niall (author)Researchers often lack critical information to decide what type of integrated research approach - multi-, inter- or transdisciplinary - is needed at the start of a project. In the present paper, we aim to contribute insights regarding these difficulties by discussing the case study of the ongoing development of shared information management...journal article 2022
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Michel, Adrien (author), Schaefli, Bettina (author), Wever, Nander (author), Zekollari, H. (author), Lehning, Michael (author), Huwald, Hendrik (author)River ecosystems are highly sensitive to climate change and projected future increase in air temperature is expected to increase the stress for these ecosystems. Rivers are also an important socio-economic factor impacting, amongst others, agriculture, tourism, electricity production, and drinking water supply and quality. In addition to...journal article 2022
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Wever, Mark (author), Wognum, Nel (author), Shah, Munir (author), O'Leary, Niall (author), Onofrei, George (author)Systemic risks are potentially harmful events, that could severely disrupt an entire industry or economy. Examples include the bankruptcy of keystone companies and biosecurity incursions. According to the United Nations, detecting and managing systemic risk represents one of the main challenges of the 21st century. Due to increasing...conference paper 2021
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Wever, Ron (author), Renirie, R. (author), Hollmann, F. (author)In this chapter the catalytic and structural properties of the vanadium chloroperoxidases will be discussed with an emphasis on their superb activity and stability under operational conditions. These properties make these enzymes attractive catalysts in organic synthesis and allow a number of applications. Some of the more recent findings are...book chapter 2020
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Höfler, G.T. (author), But, A. (author), Younes, S.H.H. (author), Wever, Ron (author), Paul, C.E. (author), Arends, I.W.C.E. (author), Hollmann, F. (author)The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.journal article 2020
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Izeboud, M. (author), Lhermitte, S.L.M. (author), Van Tricht, K. (author), Lenaerts, J. T.M. (author), Van Lipzig, N. P.M. (author), Wever, N. (author)To better understand and quantify the impact of clouds on the Greenland Ice Sheet surface mass balance (SMB), we study the spatiotemporal variability of the cloud radiative effect (CRE). The total CRE is separated in short-term and long-term impacts by performing multiple simulations with the SNOWPACK model for 2001-+2010. The annual total...journal article 2020
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Xu, X. (author), But, A. (author), Wever, Ron (author), Hollmann, F. (author)The chemoenzymatic oxidative decarboxylation of glutamic acid to the corresponding nitrile using the vanadium chloroperoxidase from Curvularia inaequalis (CiVCPO) as HOBr generation catalysts has been investigated. Product inhibition was identified as major limitation. Nevertheless, 1630000 turnovers and k<sub>cat</sub> of 75 s<sup>−1</sup>...journal article 2020
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Dunmire, D. (author), Lenaerts, J.T.M. (author), Banwell, Alison (author), Wever, N. (author), Shragge, J. (author), Lhermitte, S.L.M. (author), Drews, R. (author), Pattyn, F. (author), Hansen, J.S.S. (author), Willis, I.C. (author), Miller, J. (author), Keenan, E. (author)Between 1992 and 2017, the Antarctic Ice Sheet (AIS) lost ice equivalent to 7.6 ± 3.9 mm of sea level rise. AIS mass loss is mitigated by ice shelves that provide a buttress by regulating ice flow from tributary glaciers. However, ice-shelf stability is threatened by meltwater ponding, which may initiate, or reactivate preexisting, fractures,...journal article 2020
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Yuan, Bo (author), Mahor, Durga (author), Fei, Qiang (author), Wever, Ron (author), Alcalde, Miguel (author), Zhang, Wuyuan (author), Hollmann, F. (author)Peroxyzymes simply use H2O2 as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H2O2 can be addressed by a controlled supply of H2O2, ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both...journal article 2020
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Wever, Mark (author), Wognum, Nel (author), Shah, Munir (author), Sharifi, Mostafa (author), Reis, Marlon M. (author)Over the last decade, transparency schemes have started to undergo a radical transformation. This transformation is driven by advancements in cloud computing, cryptography and automated measurement technology, which have made it possible to develop shared information management systems (SIMS). These SIMS form the backbone of the latest, state...conference paper 2020
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Kausch, T. (author), Lhermitte, S.L.M. (author), T. M. Lenaerts, Jan (author), Wever, Nander (author), Inoue, Mana (author), Pattyn, Frank (author), Sun, Sainan (author), Wauthy, Sarah (author), Tison, Jean-Louis (author), Jan Van De Berg, Willem (author)About 20 % of all snow accumulation in Antarctica occurs on the ice shelves. There, ice rises control the spatial surface mass balance (SMB) distribution by inducing snowfall variability and wind erosion due to their topography. Moreover these ice rises buttress the ice flow and represent ideal drilling locations for ice cores. In this study...journal article 2020
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Younes, S.H.H. (author), Tieves, F. (author), Lan, Dongming (author), Wang, Yonghua (author), Süss, Philipp (author), Brundiek, Henrike (author), Wever, Ron (author), Hollmann, F. (author)A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the...journal article 2019
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Datta, Rajashree Tri (author), Tedesco, Marco (author), Fettweis, Xavier (author), Agosta, Cecile (author), Lhermitte, S.L.M. (author), Lenaerts, Jan T.M. (author), Wever, Nander (author)Surface meltwater ponding has been implicated as a major driver for recent ice shelf collapse as well as the speedup of tributary glaciers in the northeast Antarctic Peninsula. Surface melt on the NAP is impacted by the strength and frequency of westerly winds, which result in sporadic foehn flow. We estimate changes in the frequency of foehn...journal article 2019
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Zhang, W. (author), Fernandez Fueyo, E. (author), Ni, Y. (author), van Schie, M.M.C.H. (author), Gacs, Jenö (author), Renirie, R. (author), Wever, Ron (author), Mutti, Francesco G. (author), Rother, Dörte (author), Alcalde, Miguel (author), Hollmann, F. (author)Peroxygenases offer an attractive means to address challenges in selective oxyfunctionalization chemistry. Despite this, their application in synthetic chemistry remains challenging due to their facile inactivation by the stoichiometric oxidant H<sub>2</sub>O<sub>2</sub>. Often atom-inefficient peroxide generation systems are required, which...journal article 2018
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Dong, J. (author), Fernandez Fueyo, E. (author), Li, Jingbo (author), Guo, Zheng (author), Renirie, Rokus (author), Wever, Ron (author), Hollmann, F. (author)The vanadium-dependent chloroperoxidase from Curvularia inaequalis is a stable and efficient biocatalyst for the hydroxyhalogenation of a broad range of alkenes into halohydrins. Up to 1 200 000 TON with 69 s−1 TOF were observed for the biocatalyst. A bienzymatic cascade to yield epoxides as reaction products is presented.journal article 2017
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Steger, C.R. (author), Reijmer, C.H. (author), van den Broeke, MR (author), Wever, N. (author), Forster, R.R. (author), Koenig, L.S. (author), Kuipers Munneke, P. (author), Lehning, M. (author), Lhermitte, S.L.M. (author), Ligtenberg, SRM (author), Miège, C. (author), Noël, B.P.Y. (author)Runoff has recently become the main source of mass loss from the Greenland Ice Sheet and is an important contributor to global sea level rise. Linking runoff to surface meltwater production is complex, as meltwater can be retained within the firn by refreezing or perennial liquid water storage. To constrain these uncertainties, the outputs of...journal article 2017