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van Lennep, Johan (Hans) P.A. (author), van Middendorp, Henriët (author), Veldhuijzen, Dieuwke S. (author), Peerdeman, Kaya J. (author), Blythe, Joseph S. (author), Thomaidou, Mia A. (author), Heyman, Tom (author), Evers, A.W.M. (author)
This study investigated for the first time the effects of individual and combined application of 3 learning techniques (verbal suggestions, classical conditioning, and observational learning) on placebo analgesia and extinction. Healthy participants (N = 206) were assigned to 8 different groups in which they were taught through either a...
journal article 2023
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Thomaidou, Mia A. (author), Blythe, Joseph S. (author), Veldhuijzen, Dieuwke S. (author), Peerdeman, Kaya J. (author), van Lennep, Johan (Hans) P.A. (author), Giltay, Erik J. (author), Cremers, Henk R. (author), Evers, A.W.M. (author)
Learning and negative outcome expectations can increase pain sensitivity, a phenomenon known as nocebo hyperalgesia. Here, we examined how a targeted pharmacological manipulation of learning would impact nocebo responses and their brain correlates. Participants received either a placebo (n = 27) or a single 80 mg dose of d-cycloserine (a...
journal article 2022
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van Lennep, Johan (Hans) Peter Alexander (author), Trossèl, Faye (author), Perez, Roberto Silvio Giovanni Maria (author), Otten, René Hubert Joseph (author), van Middendorp, Henriët (author), Evers, A.W.M. (author), Szadek, Karolina Maria (author)
Background and Objective: The current treatments of primary musculoskeletal low back pain (LBP) have a low to moderate efficacy, which might be improved by looking at the contribution of placebo effects. However, the size of true placebo effects in LBP is unknown. Therefore, a systematic review and meta-analysis were executed of randomized...
review 2021