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Varela, I. (author), Klijn, C.N. (author), Stephens, P.J. (author), Mudie, L.J. (author), Stebbings, L. (author), Galappaththige, D. (author), Van der Gulden, H. (author), Schut, E. (author), Klarenbeek, S. (author), Campbell, P.J. (author), Wessels, L.F.A. (author), Stratton, M.R. (author), Jonkers, J. (author), Futreal, P.A. (author), Adams, D.J. (author)
Background: Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E...
journal article 2010
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Holstege, H. (author), Van Beers, E. (author), Velds, A. (author), Liu, X. (author), Joosse, S.A. (author), Klarenbeek, S. (author), Schut, E. (author), Kerkhoven, R. (author), Klijn, C.N. (author), Wessels, L.F.A. (author), Nederlof, P.M. (author), Jonkers, J. (author)
Background: Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give...
journal article 2010