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Wahyulaksana, G. (author), Wei, Luxi (author), Schoormans, Jasper (author), Voorneveld, J.D. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Vos, H.J. (author)Suppressing tissue clutter is an essential step in blood flow estimation and visualization, even when using ultrasound contrast agents. Blind source separation (BSS)-based clutter filter for high-framerate ultrasound imaging has been reported to perform better in tissue clutter suppression than the conventional frequency-based wall filter and...journal article 2022
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Hopf, Y.M. (author), Ossenkoppele, Boudewine W. (author), Soozande, Mehdi (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, Chao (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)In this article, an application-specific integrated circuit (ASIC) for 3-D, high-frame-rate ultrasound imaging probes is presented. The design is the first to combine element-level, high-voltage (HV) transmitters and analog front-ends, subarray beamforming, and in-probe digitization in a scalable fashion for catheter-based probes. The...journal article 2022
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Guo, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)This article presents a compact analog front-end (AFE) circuit for ultrasound receivers with linear-in-dB continuous gain control for time-gain compensation (TGC). The AFE consists of two variable-gain stages, both of which employ a novel complementary current-steering network (CCSN) as the interpolator to realize continuously variable gain....journal article 2022
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Simoes dos Santos, D. (author), Fool, F. (author), Kim, Taehoon (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)Over the past decades, real-time three-dimensional (3D) medical ultrasound has attracted much attention since it enables clinicians to diagnose more accurately. This calls for ultrasound matrix transducers with a large number of elements, which can be interfaced with an application-specific integrated circuit (ASIC) for data reduction. An...conference paper 2021
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Collado Lara, G. (author), Heymans, Sophie V. (author), Rovituso, M. (author), Carlier, Bram (author), Toumia, Yosra (author), Verweij, M.D. (author), Vos, H.J. (author), de Jong, N. (author), Daeichin, V. (author)The potential of proton therapy to improve the conformity of the delivered dose to the tumor volume is currently limited by range uncertainties. Injectable superheated nanodroplets have recently been proposed for ultrasound-based in vivo range verification, as these vaporize into echogenic microbubbles on proton irradiation. In previous...journal article 2021
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Wei, Luxi (author), Wahyulaksana, G. (author), Meijlink, Bram (author), Ramalli, Alessandro (author), Noothout, E.C. (author), Verweij, M.D. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Vos, H.J. (author)Volumetric ultrasound imaging of blood flow with microbubbles enables a more complete visualization of the microvasculature. Sparse arrays are ideal candidates to perform volumetric imaging at reduced manufacturing complexity and cable count. However, due to the small number of transducer elements, sparse arrays often come with high clutter...journal article 2021
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Voorneveld, J.D. (author), Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), Mutluer, Ferit O. (author), van der Steen, A.F.W. (author), Ten Cate, Folkert (author), de Jong, N. (author), Vos, H.J. (author), Van den Bosch, Annemien E. (author), Bosch, Johan G. (author)High-frame-rate (HFR) echo-particle image velocimetry (echoPIV) is a promising tool for measuring intracardiac blood flow dynamics. In this study, we investigate the optimal ultrasound contrast agent (UCA: SonoVue) infusion rate and acoustic output to use for HFR echoPIV (PRF = 4900 Hz) in the left ventricle (LV) of patients. Three infusion...journal article 2021
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Waasdorp, R. (author), Mugge, W. (author), Vos, H.J. (author), De Groot, Jurriaan H. (author), Verweij, M.D. (author), de Jong, N. (author), Schouten, A.C. (author), Daeichin, V. (author)Skeletal muscles generate force, enabling movement through a series of fast electro-mechanical activations coordinated by the central nervous system. Understanding the underlying mechanism of such fast muscle dynamics is essential in neuromuscular diagnostics, rehabilitation medicine and sports biomechanics. The unique combination of...journal article 2021
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Sabbadini, A. (author), Caenen, A.F.M. (author), Keijzer, L.B.H. (author), van Neer, P.L.M.J. (author), Vos, H.J. (author), de Jong, N. (author), Verweij, M.D. (author)Shear wave elastography (SWE) has the potential to determine cardiac tissue stiffness from non-invasive shear wave speed measurements, important, e.g., for predicting heart failure. Previous studies showed that waves traveling in the interventricular septum (IVS) may display Lamb-like dispersive behaviour, introducing a thickness-frequency...journal article 2021
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Kim, Taehoon (author), Fool, F. (author), Simoes dos Santos, D. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This paper presents an ultrasound transceiver application-specific integrated circuit (ASIC) directly integrated with an array of 12 × 80 piezoelectric transducer elements to enable next-generation ultrasound probes for 3D carotid artery imaging. The ASIC, implemented in a 0.18 µm high-voltage Bipolar-CMOS-DMOS (HV BCD) process, adopted a...journal article 2021
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Keijzer, Lana B.H. (author), Caenen, A.F.M. (author), Voorneveld, J.D. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, Johan G. (author), Vos, H.J. (author)Natural and active shear wave elastography (SWE) are potential ultrasound-based techniques to non-invasively assess myocardial stiffness, which could improve current diagnosis of heart failure. This study aims to bridge the knowledge gap between both techniques and discuss their respective impacts on cardiac stiffness evaluation. We recorded...journal article 2020
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Sabbadini, A. (author), Keijzer, L.B.H. (author), Vos, H.J. (author), de Jong, N. (author), Verweij, M.D. (author)Shear wave elastography (SWE) might allow non-invasive assessment of cardiac stiffness by relating shear wave propagation speed to material properties. However, after aortic valve closure, when natural shear waves occur in the septal wall, the stiffness of the muscle decreases significantly, and the effects of such temporal variation of...journal article 2020
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Chen, Z. (author), Soozande, M. (author), Vos, H.J. (author), Bosch, J.G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This article quantitatively analyzes the impact of bit errors in digitized RF data on ultrasound image quality. The quality of B-mode images in both linear array and phased array imaging is evaluated by means of three objective image quality metrics: peak signal-to-noise ratio, structural similarity index, and contrast-to-noise ratio, when...journal article 2020
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Mozaffarzadeh, M. (author), Soozande, M. (author), Fool, F. (author), Pertijs, M.A.P. (author), Vos, H.J. (author), Verweij, M.D. (author), Bosch, Johan G. (author), de Jong, N. (author)Recently, we realized a prototype matrix transducer consisting of 48 rows of 80 elements on top of a tiled set of Application Specific Integrated Circuits (ASICs) implementing a row-level control connecting one transmit/receive channel to an arbitrary subset of elements per row. A fully sampled array data acquisition is implemented by a...journal article 2020
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Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, Tom (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, Johan G. (author)Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...journal article 2020
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Sabbadini, A. (author), Caenen, A.F.M. (author), Vos, H.J. (author), de Jong, N. (author), Verweij, M.D. (author)Shear Wave Elastography (SWE) has been proposed to investigate cardiac health by non-invasively monitoring tissue stiffness. Previous work has shown that the plate-like geometry of the Interventricular Septum (IVS) may result in a dispersion similar to Lamb waves, complicating the link between shear wave speed and cardiac stiffness. However, the...journal article 2019
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- Soozande, Mehdi (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Vos, H.J. (author), Bosch, J.G. (author), de Jong, N. (author) poster 2019
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Waasdorp, R. (author), Mugge, W. (author), Vos, H.J. (author), de Groot, J.H. (author), de Jong, N. (author), Verweij, M.D. (author), Schouten, A.C. (author), Daeichin, V. (author)Current methods to track the progression and evaluate treatment of muscular dystrophies are scarce. The electromechanical delay (EMD), defined as the time lag from muscle electrical activity to motion onset, has been proposed as a biomarker, but provides only limited insight in the pathophysiol-ogy of muscle function. This work proposes and...conference paper 2019
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Fool, F. (author), Vos, H.J. (author), Shabanimotlagh, M. (author), Soozande, M. (author), Mozaffarzadeh, M. (author), Kim, T. (author), Kang, E. (author), Pertijs, M.A.P. (author), de Jong, N. (author), Verweij, M.D. (author)To accurately investigate the state of the carotid artery by the local haemodynamics and motion of the plaque using ultrasound, high-frame rate volumetric imaging is necessary. We have specifically designed a matrix array for this purpose. In this proceeding we will focus on imaging a volumetric flow profile using this matrix. For this...conference paper 2019
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Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Dan J. (author), Geleijnse, Marcel L. (author), van der Steen, A.F.W. (author), Bosch, Johan G. (author), de Jong, N. (author), Vos, H.J. (author)For the quantification of myocardial function, myocardial stiffness can potentially be measured non-invasively using shear wave elastography. Clinical diagnosis requires high precision. In 10 healthy volunteers, we studied the reproducibility of the measurement of propagation speeds of shear waves induced by aortic and mitral valve closure ...journal article 2019