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Contribution of Red Blood Cells and Platelets to Blood Clot Computed Tomography Imaging and Compressive Mechanical Characteristics

Cahalane, Rachel M.E. (author), Cruts, Janneke M.H. (author), van Beusekom, Heleen M.M. (author), de Maat, Moniek P.M. (author), Dijkshoorn, Marcel (author), van der Lugt, Aad (author), Gijsen, F.J.H. (author)

Thrombus computed tomography (CT) imaging characteristics may correspond with thrombus mechanical properties and thus predict thrombectomy success. The impact of red blood cell (RBC) content on these properties (imaging and mechanics) has been widely studied. However, the additional effect of platelets has not been considered. The objective...

journal article 2024

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The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics

Jansen, Imke (author), Cahalane, Rachel (author), Hengst, Ranmadusha (author), Akyildiz, A.C. (author), Farrell, Eric (author), Gijsen, F.J.H. (author), Aikawa, Elena (author), van der Heiden, Kim (author), Wissing, Tamar (author)

The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovascular events. In essence, the rupture of the plaque cap is a mechanical event, which occurs when the local stress exceeds the local tissue strength. However, due to inter- and intra-cap heterogeneity, the resulting ultimate...

review 2024

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Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models

Wieringa, André (author), Ewoldt, Tim (author), Gangapersad, Ravish N. (author), Gijsen, Matthias (author), Parolya, N. (author), Kats, Chantal J. A. R. (author), Spriet, Isabel (author), Endeman, Henrik (author), Haringman, Jasper J. (author)

In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likelihood of clinical success. To optimize antibiotic treatment, we aimed to develop beta-lactam target...

journal article 2023

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The association between human blood clot analogue computed tomography imaging, composition, contraction, and mechanical characteristics

Cruts, Janneke M. H. (author), Giezen, Jo-Anne (author), van Gaalen, Kim (author), Beurskens, Robert (author), Ridwan, Yanto (author), Dijkshoorn, Marcel L. (author), Boodt, Nikki (author), Gijsen, F.J.H. (author), Cahalane, R.M.E. (author)

Background<br/>Clot composition, contraction, and mechanical properties are likely determinants of endovascular thrombectomy success. A pre-interventional estimation of these properties is hypothesized to aid in selecting the most suitable treatment for different types of thrombi. Here we determined the association between the aforementioned...

journal article 2023

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Tensile and Compressive Mechanical Behaviour of Human Blood Clot Analogues

Cahalane, R.M.E. (author), de Vries, J.J. (author), de Maat, Moniek P.M. (author), van Gaalen, Kim (author), van Beusekom, Heleen M. (author), van der Lugt, Aad (author), Fereidoonnezhad, B.F. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)

Endovascular thrombectomy procedures are significantly influenced by the mechanical response of thrombi to the multi-axial loading imposed during retrieval. Compression tests are commonly used to determine compressive ex vivo thrombus and clot analogue stiffness. However, there is a shortage of data in tension. This study compares the tensile...

journal article 2023

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Cross-Sectional Validation of a Novel Computed Tomography-Based Carotid Mean Calcium Density Measurement

Cahalane, R.M.E. (author), Akyildiz, A.C. (author), Kavousi, Maryam (author), Vernooij, Meike W. (author), Ikram, M. Kamran (author), Gijsen, F.J.H. (author), Bos, Daniel (author)

Background The purpose of this study was to validate a technique for measuring mean calcium density and to determine associations of cardiovascular risk factors with carotid calcium density. Methods and Results We performed a cross-sectional study in a random sample of 100 stroke-free participants from the population-based Rotterdam Study....

journal article 2023

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A tissue-engineered model of the atherosclerotic plaque cap: Toward understanding the role of microcalcifications in plaque rupture

Jansen, Imke (author), Crielaard, Hanneke (author), Wissing, Tamar (author), Bouten, Carlijn (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author), Farrell, Eric (author), van der Heiden, Kim (author)

Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has been suggested, through computational models, that the presence of microcalcifications in the atherosclerotic cap can increase the risk of cap rupture. However, the experimental confirmation of this hypothesis is still lacking. In this study,...

journal article 2023

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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Crielaard, Hanneke (author), Guvenir Torun, Su (author), Wissing, Tamar B. (author), de Miguel Muñoz, Pablo (author), Kremers, Gert Jan (author), Gijsen, F.J.H. (author), Van Der Heiden, Kim (author), Akyildiz, A.C. (author)

The rupture of atherosclerotic plaques in coronary and carotid arteries is the primary cause of fatal cardiovascular events. However, the rupture mechanics of the heterogeneous, highly collagenous plaque tissue, and how this is related to the tissue's fibrous structure, are not known yet. Existing pipelines to study plaque mechanics are...

journal article 2022

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Multicomponent material property characterization of atherosclerotic human carotid arteries through a Bayesian Optimization based inverse finite element approach

Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), de Korte, Chris L. (author), van der Steen, Antonius F.W. (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author)

Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid...

journal article 2022

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Thrombus mechanics: How can we contribute to improve diagnostics and treatment?

Migliavacca, Francesco (author), Luraghi, G. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)

contribution to periodical 2022

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Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study

Luraghi, G. (author), Bridio, Sara (author), Lissoni, Vittorio (author), Dubini, Gabriele (author), Dwivedi, Anushree (author), McCarthy, Ray (author), Fereidoonnezhad, B.F. (author), McGarry, Patrick (author), Gijsen, F.J.H. (author)

Mechanical thrombectomy (MT) treatment of acute ischemic stroke (AIS) patients typically involves use of stent retrievers or aspiration catheters alone or in combination. For in silico trials of AIS patients, it is crucial to incorporate the possibility of thrombus fragmentation during the intervention. This study focuses on two aspects of...

journal article 2022

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The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis

Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author)

The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two...

journal article 2022

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Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture

Wissing, T. B. (author), Van der Heiden, K. (author), Serra, S.M. (author), Smits, A. I.P.M. (author), Bouten, C. V.C. (author), Gijsen, F.J.H. (author)

A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material properties, and the stochastic nature of the event. Here, we aim to create tissue engineered...

journal article 2022

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Morphometric and Mechanical Analyses of Calcifications and Fibrous Plaque Tissue in Carotid Arteries for Plaque Rupture Risk Assessment

Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)

Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...

journal article 2021

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Identification of the haemodynamic environment permissive for plaque erosion

McElroy, Michael (author), Kim, Yongcheol (author), Niccoli, Giampaolo (author), Vergallo, Rocco (author), Langford-Smith, Alexander (author), Crea, Filippo (author), Gijsen, F.J.H. (author), Johnson, Thomas (author), Keshmiri, Amir (author)

Endothelial erosion of atherosclerotic plaques is the underlying cause of approximately 30% of acute coronary syndromes (ACS). As the vascular endothelium is profoundly affected by the haemodynamic environment to which it is exposed, we employed computational fluid dynamic (CFD) analysis of the luminal geometry from 17 patients with optical...

journal article 2021

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SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture

Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author)

Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....

journal article 2021

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Mechanical Characterization of Thrombi Retrieved with Endovascular Thrombectomy in Patients with Acute Ischemic Stroke

Boodt, Nikki (author), Snouckaert Van Schauburg, Philip R.W. (author), Hund, Hajo M. (author), Fereidoonnezhad, B.F. (author), McGarry, J. Patrick (author), Akyildiz, A.C. (author), Van Es, Adriaan C.G.M. (author), Van Der Lugt, Aad (author), Gijsen, F.J.H. (author)

Background and Purpose: Mechanical properties of thromboemboli play an important role in the efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke. However, very limited data on mechanical properties of human stroke thrombi are available. We aimed to mechanically characterize thrombi retrieved with EVT, and to assess the...

journal article 2021

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Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach

Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)

Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...

journal article 2020

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4-D Echo-Particle Image Velocimetry in a Left Ventricular Phantom

Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, Tom (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, Johan G. (author)

Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...

journal article 2020

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Tomographic PIV in a model of the left ventricle: 3D flow past biological and mechanical heart valves

Saaid, Hicham (author), Voorneveld, Jason (author), Schinkel, C.V. (author), Westenberg, Jos (author), Gijsen, F.J.H. (author), Segers, Patrick (author), Verdonck, Pascal (author), de Jong, N. (author), Kenjeres, S. (author)

Left ventricular flow is intrinsically complex, three-dimensional and unsteady. Its features are susceptible to cardiovascular pathology and treatment, in particular to surgical interventions involving the valves (mitral valve replacement). To improve our understanding of intraventricular fluid mechanics and the impact of various types of...

journal article 2019