Low-cost shaping of electrical stimulation waveforms for bioelectronic medicine with improved efficiency and selectivity

Electrical stimulation is proven to be an effective way of neuromodulation in bioelectronic medicine (e.g. cochlear implants, deep brain stimulators, etc.), delivering localized treatment by the means of electrical pulses. To increase the stimulation efficiency and neural-type selectivity, there is an increasing interest to employ non...

Multichannel current-mode stimulator with channel-specific regulated power supply

Developing neuroprosthetic bioelectronic devices requires wirelessly-powered implantable stimulator systems with hundreds to thousands of output channels. Power efficiency optimization is crucial for scaling up the number of output channels. Current-mode electrical stimulation is favored for safety but is power-inefficient in conventional...

Energy efficiency of pulse shaping in electrical stimulation: the interdependence of biophysical effects and circuit design losses

Power efficiency in electrical stimulator circuits is crucial for developing large-scale multichannel applications like bidirectional brain-computer interfaces and neuroprosthetic devices. Many state-of-the-art papers have suggested that some non-rectangular pulse shapes are more energy-efficient for exciting neural excitation than the...

Pre-Filtering of Stimuli for Improved Energy Efficiency in Electrical Neural Stimulation

This work proposes a guideline for designing more energy-efficient electrical stimulators by analyzing the frequency spectrum of the stimuli. It is shown that the natural low-pass characteristic of the neuron’s membrane limits the energy transfer efficiency from the stimulator to the cell. Thus, to improve the transfer efficiency, it is proposed...

Stent with Piezoelectric Transducers for High Spatial Resolution Ultrasound Neuromodulation- a Finite Element Analysis

Deep brain stimulation is currently the only technique used in the clinical setting to modulate the neural activity of deep brain nuclei. Recently, low-intensity transcranial focused ultrasound (LIFU) has been shown to reversibly modulate brain activity through a transcranial pathway. Transcranial LIFU requires a low-frequency ultrasound of...