On the identification of hypoxic regions in subject-specific cerebral vasculature by combined CFD/MRI

A long-time exposure to lack of oxygen (hypoxia) in some regions of the cerebrovascular system is believed to be one of the causes of cerebral neurological diseases. In the present study, we show how a combination of magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) can provide a noninvasive alternative for studying...

Subclinical liver traits are associated with structural and hemodynamic brain imaging markers

Background & Aims: Impaired liver function affects brain health and therefore understanding potential mechanisms for subclinical liver disease is essential. We assessed the liver–brain associations using liver measures with brain imaging markers, and cognitive measures in the general population. Methods: Within the population-based...

Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art...

A 1024-Channel 268 nW/pixel 36x36 μm²/ch Data-Compressive Neural Recording IC for High-Bandwidth Brain-Computer Interfaces

This paper presents a neural recording IC featuring lossy compression during digitization, thus preventing data deluge and enabling a compact active digital pixel design. The wired-OR-based compression discards unwanted baseline samples while allowing the reconstruction of spike samples. The IC features a 32x32 MEA with 36 μ m pixel pitch and...

GLM-Regularized Low-Rank Factorization For Extracting Functional Response From Swept-3D Functional Ultrasound

Functional ultrasound (fUS) is an emerging neuroimaging modality that indirectly measures neural activity by detecting fluctuations in local blood dynamics. fUS acquisitions typically rely on the use of a 1D array transducer, which records hemodynamic activity in a single plane. A new technique named swept-3D fUS imaging obtains a full 3D...

Advanced MR Techniques for Preoperative Glioma Characterization: Part 1

Preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise...

Adaptive optics in single objective inclined light sheet microscopy enables three-dimensional localization microscopy in adult Drosophila brains

Single-molecule localization microscopy (SMLM) enables the high-resolution visualization of organelle structures and the precise localization of individual proteins. However, the expected resolution is not achieved in tissue as the imaging conditions deteriorate. Sample-induced aberrations distort the point spread function (PSF), and high...

Timing and localization of myasthenia gravis-related gene expression

Myasthenia gravis (MG) is an acquired autoimmune disorder caused by autoantibodies binding acetylcholine receptors (AChR), muscle-specific kinase (MuSK), agrin or low-density lipoprotein receptor-related protein 4 (Lrp4). These autoantibodies inhibit neuromuscular transmission by blocking the function of these proteins and thereby cause...

Organ-on-Silicon

The cost and the development time of pharamecutical products are often severely affected by the in vitro tests currently employed in pharmaceutical R&D. These assays are often failing to accurately recapitulate diseases and to predict human responses to new medicines. Organ-on-Chip (OOC) devices are designed to result in advanced in vitro...

Assessing brain structure and function with diffusion-weighted MRI: Application to stroke

Human brain consists of grey and white matter. Grey matter largely forms the<br/>outer layer of the brain, and is responsible for decision making and functioning<br/>of the human body. Complementary, the white matter (WM) contains the<br/>communication pathways between the grey matter areas. Diffusion-weighted<br/>magnetic resonance imaging ...

Wavefield focusing with reduced cranial invasiveness

Wavefield focusing can be achieved by Time-Reversal Mirrors, which involve in- and output signals that are infinite in time and waves propagating through the entire medium. Here, an alternative solution for wavefield focusing is presented. This solution is based on a new integral representation where in- and output signals are finite in time,...