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Li, G. (author), Trausel, F. (author), van der Helm, M. (author), Klemm, B. (author), Breve, T. (author), van Rossum, S.A.P. (author), Hartono, Muhamad (author), Gerlings, Harm H.P.J. (author), Lovrak, M. (author), van Esch, J.H. (author), Eelkema, R. (author)Dynamic regulation of chemical reactivity is important in many complex chemical reaction networks, such as cascade reactions and signal transduction processes. Signal responsive catalysts could play a crucial role in regulating these reaction pathways. Recently, supramolecular encapsulation was reported to regulate the activities of...journal article 2021
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van den Berg, Boudewijn (author), Manoochehri, M. (author), Kasting, Mindy (author), Schouten, A.C. (author), van der Helm, F.C.T. (author), Buitenweg, Jan R. (author)A sustained sensory stimulus with a periodic variation of intensity creates an electrophysiological brain response at associated frequencies, referred to as the steady-state evoked potential (SSEP). The SSEPs elicited by the periodic stimulation of nociceptors in the skin may represent activity of a brain network that is primarily involved in...journal article 2021
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Geelen, J.E. (author), Branco, Mariana P. (author), Ramsey, Nick F. (author), van der Helm, F.C.T. (author), Mugge, W. (author), Schouten, A.C. (author)Motion capture systems are extensively used to track human movement to study healthy and pathological movements, allowing for objective diagnosis and effective therapy of conditions that affect our motor system. Current motion capture systems typically require marker placements which is cumbersome and can lead to contrived movements.Here, we...conference paper 2021
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van der Helm, M. (author), de Beun, Tuanke (author), Eelkema, R. (author)Catalysis is an essential function in living systems and provides a way to control complex reaction networks. In natural out-of-equilibrium chemical reaction networks (CRNs) driven by the consumption of chemical fuels, enzymes provide catalytic control over pathway kinetics, giving rise to complex functions. Catalytic regulation of man-made...journal article 2021
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van Trigt, B. (author), Leenen, A.J.R. (author), Hoozemans, Marco J.M. (author), van der Helm, F.C.T. (author), Veeger, H.E.J. (author)Upper extremity injuries are common in baseball. One of these is the ulnar collateral ligament (UCL) injury. In the field of sports injuries, most research focuses on average kinematics and kinetics between subjects, whereas focusing on within-subject variability appears to be more relevant for determining injury risk. We constructed a simple...journal article 2020
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Yang, Y. (author), Yao, Jun (author), Dewald, Julius (author), van der Helm, F.C.T. (author), Schouten, A.C. (author)This paper introduces the Cross-frequency Amplitude Transfer Function (CATF), a model-free method for quantifying nonlinear stimulus-response interaction based on phase-locked amplitude relationship. The CATF estimates the amplitude transfer from input frequencies at stimulation signal to their harmonics/intermodulation at the response signal....journal article 2020
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Lemus Perez, D.S. (author), Berry, Andrew (author), Jabeen, S. (author), Jayaraman, Chandrasekaran (author), Hohl, Kristen (author), van der Helm, F.C.T. (author), Jayaraman, Arun (author), Vallery, H. (author)Gyroscopic actuators are appealing for wearable applications due to their ability to provide overground balance support without obstructing the legs. Multiple wearable robots using this actuation principle have been proposed, but none has yet been evaluated with humans. Here we use the GyBAR, a backpack-like prototype portable robot, to...journal article 2020
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Breve, T. (author), Filius, M. (author), Araman, Can (author), van der Helm, M. (author), Hagedoorn, P.L. (author), Joo, C. (author), van Kasteren, Sander I. (author), Eelkema, R. (author)Supramolecular encapsulation is known to alter chemical properties of guest molecules. We have applied this strategy of molecular encapsulation to temporally control the catalytic activity of a stable copper(I)–carbene catalyst. Encapsulation of the copper(I)–carbene catalyst by the supramolecular host cucurbit[7]uril (CB[7]) resulted in the...journal article 2020
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Bastiaansen, Bram J.C. (author), Wilmes, Erik (author), Brink, Michel S. (author), de Ruiter, Cornelis J. (author), Savelsbergh, Geert J.P. (author), Steijlen, A.S.M. (author), Jansen, K.M.B. (author), van der Helm, F.C.T. (author), Goedhart, Edwin A. (author), van der Laan, Doris (author), Vegter, Riemer J.K. (author), Lemmink, Koen A.P.M. (author)Current athlete monitoring practice in team sports is mainly based on positional data measured by global positioning or local positioning systems. The disadvantage of these measurement systems is that they do not register lower extremity kinematics, which could be a useful measure for identifying injury-risk factors. Rapid development in...journal article 2020
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van der Helm, M. (author), Wang, Chang Lin (author), Fan, B. (author), Macchione, M. (author), Mendes, E. (author), Eelkema, R. (author)Signal transduction in living systems is the conversion of information into a chemical change, and is the principal process by which cells communicate. In nature, these functions are encoded in non-equilibrium (bio)chemical reaction networks (CRNs) controlled by enzymes. However, man-made catalytically controlled networks are rare. We...journal article 2020
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Zhou, Yuntao (author), Piergentili, I. (author), Hong, Jennifer (author), van der Helm, M. (author), Macchione, M. (author), Li, Y. (author), Eelkema, R. (author), Luo, Sanzhong (author)Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an...journal article 2020
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Happee, R. (author), de Bruijn, E. (author), Forbes, Patrick (author), van Drunen, P. (author), van Dieën, Jaap H. (author), van der Helm, F.C.T. (author)The human head-neck system requires continuous muscular stabilization in the presence of gravity and trunk motion. This chapter presents experimental and modeling efforts, applying mechanical perturbations to seated subjects, evaluating trunk and head motion, to investigate postural stabilization.<br/><br/>A detailed multisegment neck model has...book chapter 2019
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van der Helm, M. (author), Bracco Garcia, M.P. (author), Busch, H. (author), Szymańska, Katarzyna (author), Jarzȩbski, Andrzej B. (author), Hanefeld, U. (author)Enzymes are supreme catalysts when it comes to high enantiopurities and their immobilization will pave the way for continuous operation. In this context, we show the covalent immobilization of hydroxynitrile lyases HbHNL (from Hevea brasiliensis) and MeHNL (from Manihot esculenta) in a siliceous monolithic microreactor for continuous...journal article 2019
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van der Helm, Steven (author), Coppola, M. (author), McGuire, K.N. (author), de Croon, G.C.H.E. (author)We present a range-based solution for indoor relative localization by micro air vehicles (MAVs), achieving sufficient accuracy for leader–follower flight. Moving forward from previous work, we removed the dependency on a common heading measurement by the MAVs, making the relative localization accuracy independent of magnetometer readings. We...journal article 2019
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van der Helm, M. (author), Klemm, B. (author), Eelkema, R. (author)Even though enzymes are the cornerstones of living systems, it has so far proven difficult to deploy artificial catalysts in a biological setting. Organocatalysts are arguably well-suited artificial catalysts for this purpose because, compared with enzymes and inorganic catalysts, they are simpler, often less toxic and widely accessible. This...review 2019
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- Bendor, R. (author), van der Helm, A.J.C. (author), Jaśkiewicz, T.J. (author) book 2018
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Naddaf Dezfuli, S. (author), Brouwer, J.C. (author), Mol, J.M.C. (author), van der Helm, F.C.T. (author), Zhou, J. (author)Recent studies have shown great potential of Mg matrix composites for biodegradable orthopedic devices. However, the poor structural integrity of these composites, which results in excessive localized corrosion and premature mechanical failure, has hindered their widespread applications. In this research, an in-situ Powder Metallurgy (PM)...journal article 2018
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Vlaar, M.P. (author), Birpoutsoukis, Georgios (author), Lataire, John (author), Schouten, A.C. (author), Schoukens, Johan (author), van der Helm, F.C.T. (author)Joint manipulation elicits a response from the sensors in the periphery which, via the spinal cord, arrives in the cortex. The average evoked cortical response recorded using electroencephalography was shown to be highly nonlinear; a linear model can only explain 10% of the variance of the evoked response, and over 80% of the response is...journal article 2018
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Filatova, O.G. (author), van Vliet, L.J. (author), Schouten, A.C. (author), Kwakkel, Gert (author), van der Helm, F.C.T. (author), Vos, F.M. (author)Better insight into white matter (WM) alterations after stroke onset could help to understand the underlying recovery mechanisms and improve future interventions. MR diffusion imaging enables to assess such changes. Our goal was to investigate the relation of WM diffusion characteristics derived from diffusion models of increasing complexity...journal article 2018
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Chen, B. (author), Medici, R. (author), van der Helm, M. (author), van Zwet, Y.A.A. (author), Gjonaj, L. (author), van der Geest, R.C.S. (author), Otten, L.G. (author), Hanefeld, U. (author)Rhodococcus strains are ubiquitous in nature and known to metabolise a wide variety of compounds. At the same time, asymmetric reduction of C=C bonds is important in the production of high-valued chiral building blocks. In order to evaluate if Rhodococci can be used for this task, we have probed several Rhodococcus rhodochrous and R....journal article 2018