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Nanbakhsh, K. (author), Kluba, M.M. (author), Pahl, Barbara (author), Bourgeois, Florian (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Platinum is widely used as the electrode material for implantable devices. Owing to its high biostability and corrosion resistivity, platinum could also be used as the main metallization for tracks in active implants. Towards this goal, in this work we investigate the stability of parylene-coated Pt tracks using passive and active tests. The...conference paper 2019
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Akgün, O.C. (author), Serdijn, W.A. (author)With the continuous developments in science and engineering, specifically in the fields of electronics and manufacturing, implantable electronic devices have become a reality during the last decades. Implantable electronic devices have hard design constraints: 1) As small size as possible to reduce tissue damage, 2) Minimum heat generation to...abstract 2019
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Wardhana, Gandhika K (author), Serdijn, W.A. (author), Vollebregt, S. (author), Giagka, Vasiliki (author), Vollebregt, Sten (author)Neural interface in the form of microelectrodes are used to monitor and treat spinal cord injury and other neurological disorders by the means of recording and stimulation. Despite of the apparent result of these electrical interventions, understanding of the mechanism behind neural stimulation is still inadequate. The use of optical monitoring...abstract 2019
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Bakhshaee Babaroud, N. (author), Kluba, M.M. (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Active implantable medical devices have been developed for diagnosis, monitoring and treatment of large variety of neural disorders. Since the mechanical properties of these devices need to be matched to the tissue, soft materials, such as polymers are often preferred as a substrate [1]. Parylene is a good candidate, as it is highly...abstract 2019
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Malissovas, Anastasios (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)As the era of Bioelectronic medicines (BEms) evolves, new technological challenges are generated, including miniaturized devices that are encapsulated with flexible materials and energized by wireless power transmission (WPT) techniques. Among them, magnetostatic, also known as inductive, and ultrasound (US) are the most viable candidates for...abstract 2019
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Martins Da Ponte, R. (author), Huang, C. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)Optogenetics is a neuromodulation method that holds great potential for the realization of advanced neuroprostheses due to its precise spatial-temporal control of neuronal activity [1]. The development of novel optogenetic implants (optrodes) may open new doors to investigate complex brain circuitry and chronical brain disorders, such as...abstract 2019
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Martins Da Ponte, R. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)Incubators in cell cultures are used to grow and maintain cells under optimal temperature alongside other key variables, such as pH, humidity, atmospheric conditions etc. As enzymatic activity and protein synthesis proceed optimally at 37.5 oC, a temperature rise can cause protein denaturation, whereas a drop in temperature can slow down...abstract 2019
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Nanbakhsh, K. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)The main goal of bioelectronic medicine is to, one day, replace conventional chemical drugs with miniaturized implants. This way, tiny electrical pulses will be locally delivered to a small group of neurons in order to influence and modify biological functions. Developing such implants, however, has brought many new challenges both in the...abstract 2019
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Pak, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Electronic components in the form of application-specific integrated circuits (ASICs) establishing the communication between the body and the implant, such as stimulation and recording, have, nowadays, become essential elements for current and future generations of implantable devices, as medicine is looking into substituting its traditional...abstract 2019
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Martins Da Ponte, R. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)This research reports on the design and co-fabrication of a time-mode signal-processing in situ temperature sensor customized for the Cytostrech, an organ-on-a-chip (OOC) device. The circuit was fabricated using an in-house integrated circuit technology (BiCMOS7) that requires only seven lithographic steps to fabricate npn and MOS devices, and...abstract 2019
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Hosman, T.B. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Electronic implants are becoming a valuable tool to explore as well as regulate neural activity, potentially overcoming neural disabilities that are not yet curable. For effective exploration and regulation, it has become increasingly necessary to cover larger areas of neural tissue and to interact at a higher resolution by means of electrode...abstract 2019
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Pak, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Electronic components in the form of application-specific integrated circuits (ASICs) establishing the communication between the body and the implant, such as stimulation and recording, have, nowadays, become essential elements for current and future generations of implantable devices, as medicine is looking into substituting its traditional...abstract 2019
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Akgün, O.C. (author), Mangia, Mauro (author), Pareschi, Fabio (author), Rovatti, Riccardo (author), Setti, Gianluca (author), Serdijn, W.A. (author)This paper presents the design of an ultra-low energy, rakeness-based compressed sensing (CS) system that utilizes time-mode (TM) signal processing (TMSP). To realize TM CS operation, the presented implementation makes use of monostable multivibrator based analog-to-time converters, fixed-width pulse generators, basic digital gates and an...conference paper 2019
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Urso, A. (author), Giagka, Vasiliki (author), van Dongen, M.N. (author), Serdijn, W.A. (author)In order to recruit neurons in excitable tissue, constant current neural stimulators are commonly used. Recently, ultra high-frequency (UHF) stimulation has been proposed and proven to have the same efficacy as constant-current stimulation. UHF stimulation uses a fundamentally different way of activating the tissue: each stimulation phase is...journal article 2019
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Urso, A. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)This manuscript points out some mistakes in the Introduction and in the table of comparison of a paper already published in this journal by Hsu and Schmid [1]. Although the main claim of [1] is still preserved, we believe the paper needs to be rectified for scientific correctness of the work. In [1], the first High Frequency Switched...journal article 2019
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Rout, S. (author), Mangia, Mauro (author), Pareschi, Fabio (author), Setti, Gianluca (author), Rovatti, Riccardo (author), Serdijn, W.A. (author)Atrial electrograms (AEGs) acquired with a high spatio-temporal resolution are a promising approach for early detection of atrial fibrillation. Due to the high data rate, transmission of AEG signals is expensive in terms of power consumption and resources, making its adoption a challenge for low-power wireless devices. In this paper, we...abstract 2019
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Urso, A. (author), Serdijn, W.A. (author)In this paper, a power-efficient multiphase Recursive Switched Capacitor (RSC) converter is presented. Conventionally, RSC converters are used to obtain many different output voltages from a fixed input voltage. Here, the converter provides a fixed output voltage of 1 V at 1 mA from an input voltage ranging from 1.4 V to 4.5 V. It has one...conference paper 2018
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Giagka, Vasiliki (author), Serdijn, W.A. (author)Patients suffering from conditions such as paralysis, diabetes or rheumatoid arthritis could in the future be treated in a personalised manner using bioelectronic medicines (BEms) (Nat Rev Drug Discov 13:399–400, 2013, Proc Natl Acad Sci USA 113:8284–9, 2016, J Intern Med 282:37–45, 2017). To deliver this personalised therapy based on...journal article 2018
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Rezaeiyan, Y. (author), Zamani, M. (author), Shoaei, Omid (author), Serdijn, W.A. (author)There is an increasing demand for low power, low voltage, and small size analog readout bio-potential systems. This paper presents an analog front-end for measuring the intra-cardiac signals in implantable and also external ambulatory ECG cardiac recording applications. The analog front-end benefits from voltage to frequency conversion...journal article 2018
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Dezyani, M. (author), Ghafoorifard, Hassan (author), Sheikhaei, Samad (author), Serdijn, W.A. (author)This paper presents a 60 mV input voltage start-up system for thermoelectric energy harvesting. A new process tolerant inverter cell is proposed, which is functional at supply voltages as low as 60 mV. Using the proposed unit cell, a ring <br/>oscillator has been implemented. The ring oscillator is followed by 40 charge-pump stages, an ultra...journal article 2018