Integrated learning of mutational signatures and prediction of DNA repair deficiencies

Motivation: Many tumors show deficiencies in DNA damage repair. These deficiencies can play a role in the disease, but also expose vulnerabilities with therapeutic potential. Targeted treatments exploit specific repair deficiencies, for instance based on synthetic lethality. To decide which patients could benefit from such therapies requires the...

Effects of flexible water level management on flood risk in areas outside primary levees around the IJsselmeer and Markermeer

Since 2019, Rijkswaterstaat has been applying flexible water level management in the IJsselmeer and Markermeer to make the Dutch water system more robust and future proof. The fixed target water level of -0.20 m NAP during summer is replaced by a flexible water level in which the water level can fluctuate between -0.10 and -0.30 m NAP to enlarge...

Exploring new Coloring Methods for Image Triangulations

Minimalistic, low-poly images have gotten more popular in recent years. But making these low-poly images by hand can be time intensive. For this reason, a lot of research has gone into how to triangulate an image (semi-)automatically. In previous works, only constant color and bilinear interpolation have been used to color the triangles in the...

(in)human architecture: The confrontation between automated waste infrastructure and the human urban context in 2100 Amsterdam

As a part of the Complex Projects Graduation Studio this project is set in 2100 Amsterdam and part of a collective research and design effort to look forward in architecture and urbanism. Due to technological advancements, automation and the advent of the circular economy, it may be advantageous to locate a recycling and sorting facility inside...

Faalkosten en budgetoverschrijdingen

Dit boekje is de neerslag van het thema ‘Faalkosten en budgetoverschrijdingen’,<br/>onderdeel van het BSc-vak ‘Bouwkunde als wetenschappelijke discipline’:<br/>Literatuuronderzoek (BK2AC1).

Field-test of nacelle-based lidar to explore its applications for Vattenfall as wind park operator

The market share of wind energy is related to many factors, including politics, social acceptance and financial feasibility. In light of reducing the Levelised Energy Cost (LEC) generated from wind energy, power company Vattenfall is continuously looking for new ways of monitoring and improving wind turbine yield. Recent publications have shown...

Investigating the Relevance of the Pecking Order Theory and the Agency Costs of Free Cash Flow Theory in the Eyes of Investors

Nowadays companies hold increased amounts of cash (Dittmar 2008; Schauten, van Dijk and Van der Waal 2008). Literature gives two contradictory theories that may influence the valuation of these cash holdings by investors in the market. The pecking order theory predicts that managers have more information about the state of the firm than outside...

De kosten voor het opzetten van een kadaster in ontwikkelingslanden

De titel van het onderzoek luidt ” de kosten voor het opzetten van een kadaster in ontwikkelingslanden Het doel van dit onderzoek was het onderzoeken van de opbouw van de kosten die ontstaan als men een kadaster in een ontwikkelingsland wil opzetten. Bij het opzetten van een nieuw kadaster, of het verbeteren van een bestaand kadastraal systeem,...

Simulatie van een kruispunt met verkeersafhankelijke regeling

A comparison has been made between several control strategies for a isolated signalized intersection* one method with a optimized fixed cycletime and four vehicle-actuated types of control. The comparison has been made by simulation on a IBM 360/65 computer. For the simplest vehicle-actuated case the results have been compared with theoretical...