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Oldhoff, M. G.E. (author), Mirzaali, Mohammad J. (author), Tümer, N. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) offers great design freedom that enables objects with desired unique and complex geometry and topology to be readily and cost-effectively fabricated. The overall benefits of AM are well known, such as increased material and resource efficiency, enhanced design and production flexibility, the ability to create...journal article 2021
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...journal article 2021
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Cuellar Lopez, J.S. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author), Breedveld, P. (author), Smit, G. (author)Various upper-limb prostheses have been designed for 3D printing but only a few of them are based on bio-inspired design principles and many anatomical details are not typically incorporated even though 3D printing offers advantages that facilitate the application of such design principles. We therefore aimed to apply a bio-inspired approach...journal article 2021
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van Hengel, I.A.J. (author), Lacin, M. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Surface biofunctionalization is frequently applied to enhance the functionality and longevity of orthopedic implants. Here, we investigated the osteogenic effects of additively manufactured porous Ti6Al4V implants whose surfaces were biofunctionalized using plasma electrolytic oxidation (PEO) in Ca/P-based electrolytes with or without...journal article 2021
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Nouri Goushki, M. (author), Angeloni, L. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Boukany, P. (author), Mirzaali, Mohammad J. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The surface topography of implantable devices is of crucial importance for guiding the cascade of events that starts from the initial contact of the cells with the surface and continues until the complete integration of the device in its immediate environment. There is, however, limited quantitative information available regarding the...journal article 2021
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Additive manufacturing of non-assembly deployable mechanisms for the treatment of large bony defectsLeeflang, M.A. (author), Bobbert, F.S.L. (author), Zadpoor, A.A. (author)Porous biomaterials are often used to treat large bony defects or fractured vertebras. Most of such biomaterials are made of metals and their alloys and have a pre-defined, fixed shape. Due to their predefined fixed shape, however, they are not suitable for implantation through minimally invasive surgical procedures. To overcome this problem,...journal article 2021
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Zadpoor, A.A. (author)Meta-biomaterials are designer biomaterials with unusual and even unprecedented properties that primarily originate from their geometrical designs at different (usually smaller) length scales. This concept has been primarily used in the context of orthopedic biomaterials with the ultimate aim of improving the bone tissue regeneration performance...journal article 2020
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van Manen, T. (author), Janbaz, S. (author), Ganjian, M. (author), Zadpoor, A.A. (author)Self-folding of complex origami-inspired structures from flat states allows for the incorporation of a multitude of surface-related functionalities into the final 3D device. Several self-folding techniques have therefore been developed during the last few years to fabricate such multi-functional devices. The vast majority of such approaches...journal article 2020
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Mirzaali, Mohammad J. (author), Cruz Saldivar, M. (author), Herranz de la Nava, Alba (author), Gunashekar, Deepthishre (author), Nouri Goushki, M. (author), Doubrovski, E.L. (author), Zadpoor, A.A. (author)Hard biological tissues (e.g., nacre and bone) have evolved for millions of years, enabling them to overcome the conflict between different mechanical properties. The key to their success lies in the combination of limited material ingredients (i.e., hard and soft constituents) and mechanistic ingredients (e.g., functional gradients and building...journal article 2020
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Kolken, H.M.A. (author), Lietaert, K. (author), van der Sloten, T. (author), Pouran, B. (author), Meynen, A. (author), Van Loock, G. (author), Weinans, Harrie (author), Scheys, L. (author), Zadpoor, A.A. (author)The innovative design of orthopedic implants could play an important role in the development of life-lasting implants, by improving both primary and secondary implant fixations. The concept of meta-biomaterials aims to achieve a unique combination of mechanical, mass transport, and biological properties through optimized topological design of...journal article 2020
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Modaresifar, K. (author), Kunkels, Lorenzo (author), Ganjian, M. (author), Tümer, N. (author), Hagen, C.W. (author), Otten, L.G. (author), Hagedoorn, P.L. (author), Angeloni, L. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Recent progress in nano-/micro-fabrication techniques has paved the way for the emergence of synthetic bactericidal patterned surfaces that are capable of killing the bacteria via mechanical mechanisms. Different design parameters are known to affect the bactericidal activity of nanopatterns. Evaluating the effects of each parameter, isolated...journal article 2020
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Mechanics of bioinspired functionally graded soft-hard composites made by multi-material 3D printingMirzaali, Mohammad J. (author), Herranz de la Nava, A. (author), Gunashekar, D. (author), Nouri Goushki, M. (author), Veeger, R. P.E. (author), Grossman, Q. (author), Angeloni, L. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Ruffoni, D. (author), Doubrovski, E.L. (author), Zadpoor, A.A. (author)Functional gradients are material transitions that are found in nature and are known to result in materials with superior properties and multiple functionalities. The emerging multi-material 3D printing (=additive manufacturing, AM) techniques provide a powerful tool for the design and fabrication of bioinspired functionally graded materials ...journal article 2020
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van Hengel, I.A.J. (author), Gelderman, F. S.A. (author), Athanasiadis, S. (author), Minneboo, M.B. (author), Weinans, Harrie (author), Fluit, A. C. (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)The holy grail of orthopedic implant design is to ward off both aseptic and septic loosening for long enough that the implant outlives the patient. Questing this holy grail is feasible only if orthopedic biomaterials possess a long list of functionalities that enable them to discharge the onerous task of permanently replacing the native bone...journal article 2020
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De Witte, Tinke Marie (author), Wagner, Angela M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Peppas, Nicholas A. (author)To guide the natural bone regeneration process, bone tissue engineering strategies rely on the development of a scaffold architecture that mimics the extracellular matrix and incorporates important extracellular signaling molecules, which promote fracture healing and bone formation pathways. Incorporation of growth factors into particles...journal article 2020
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Razzi, F. (author), Fratila-Apachitei, E.L. (author), Fahy, N. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Apachitei, I. (author), Farrell, E. (author), Zadpoor, A.A. (author)Additive manufacturing (AM) techniques have provided many opportunities for the rational design of porous metallic biomaterials with complex and precisely controlled topologies that give rise to unprecedented combinations of mechanical, physical, and biological properties. These favorable properties can be enhanced by surface...journal article 2020
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van Hengel, I.A.J. (author), Tierolf, M. W.A.M. (author), Valerio, V. P.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Effective preventive measures against implant-associated infection (IAI) are desperately needed. Therefore, the development of self-defending implants with intrinsic antibacterial properties has gained significant momentum. Biomaterials biofunctionalized with silver (Ag) have resulted in effective antibacterial biomaterials, yet regularly...journal article 2020
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Bobbert, F.S.L. (author), Janbaz, S. (author), van Manen, T. (author), Li, Y. (author), Zadpoor, A.A. (author)Deployable meta-implants aim to minimize the invasiveness of orthopaedic surgeries by allowing for changes in their shape and size that are triggered by an external stimulus. Multi-stability enables deployable implants to transform their shape from some compact retracted state to the deployed state where they take their full sizes and are...journal article 2020
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van Hengel, I.A.J. (author), Putra, N.E. (author), Tierolf, M. W.A.M. (author), Minneboo, M.B. (author), Fluit, A. C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Antibiotic-resistant bacteria are frequently involved in implant-associated infections (IAIs), making the treatment of these infections even more challenging. Therefore, multifunctional implant surfaces that simultaneously possess antibacterial activity and induce osseointegration are highly desired in order to prevent IAIs. The incorporation...journal article 2020
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Janbaz, S. (author), Narooei, K. (author), van Manen, T. (author), Zadpoor, A.A. (author)Mechanical metamaterials are usually designed to exhibit novel properties and functionalities that are rare or even unprecedented. What is common among most previous designs is the quasi-static nature of their mechanical behavior. Here, we introduce a previously unidentified class of strain rate-dependent mechanical metamaterials. The...journal article 2020
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Karami, K. (author), Blok, A. (author), Weber, L.R.M. (author), Ahmadi, S.M. (author), Petrov, R.H. (author), Nikolic, Ksenija (author), Borisov, E.V. (author), Leeflang, M.A. (author), Ayas, C. (author), Zadpoor, A.A. (author), Mehdipour, M. (author), Reinton, T.E. (author), Popovich, V. (author)Additive manufacturing technologies in general and laser powder bed fusion (L-PBF) in particular have been on the rise in different applications, including biomedical implants. The effects of the various L-PBF process parameters on the microstructure and properties of Ti6Al4V lattice structures have been studied before. However, the...journal article 2020