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de Kater, E.P. (author), Blom, M.N. (author), van Doorn, T.C. (author), Tieu, Q.H. (author), Jager, D.J. (author), Sakes, A. (author), Breedveld, P. (author)The success rate of spinal fusion surgery is mainly determined by the fixation strength of the spinal bone anchors. This study explores the use of an L-shaped spinal bone anchor that is intended to establish a macro-shape lock with the posterior cortical layer of the vertebral body, thereby increasing the pull-out resistance of the anchor. The...journal article 2024
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Lussenburg, K.M. (author), van Starkenburg, R.I.B. (author), Sakes, A. (author), Breedveld, P. (author)Metal additive manufacturing is a promising technology for the production of functional medical products, due to its high shape complexity and resolution, and ability to withstand sterilization temperatures. This study explores the possibility of designing a completely non-assembly steerable surgical instrument using Selective Laser Melting....journal article 2024
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Oud, Michelle (author), Breedveld, Sebastiaan (author), Rojo-Santiago, Jesús (author), Giżyńska, Marta Krystyna (author), Kroesen, Michiel (author), Habraken, S.J.M. (author), Perko, Z. (author), Heijmen, Ben (author), Hoogeman, M.S. (author)Objective. In head-and-neck cancer intensity modulated proton therapy, adaptive radiotherapy is currently restricted to offline re-planning, mitigating the effect of slow changes in patient anatomies. Daily online adaptations can potentially improve dosimetry. Here, a new, fully automated online re-optimization strategy is presented. In a...journal article 2024
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Trauzettel, F. (author), Vander Poorten, Emmanuel (author), Ourak, Mouloud (author), Dankelman, J. (author), Breedveld, P. (author)While articulated surgical instruments have enabled the proliferation of minimally invasive interventions, procedures such as laparo-endoscopic single-site surgery are waning in popularity. One potential reason for this decline is a lack of sufficiently dexterous instruments. Although multi-steerable instruments exist, these are often complex...journal article 2024
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Lussenburg, K.M. (author), Scali, Marta (author), Stolk, Maarten (author), Robijns, D. (author), Sakes, A. (author), Breedveld, P. (author)A vitrectome is a commonly used instrument in eye surgery, which is used to cut and aspirate the vitreous body out of the eye. The mechanism of the vitrectome consists of miniature components that need to be assembled by hand due to their size. Non-assembly 3D printing, in which fully functional mechanisms can be produced in a single production...journal article 2023
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de Kater, E.P. (author), Müller, R. (author), Sakes, A. (author), Breedveld, P. (author)The fixation strength of pedicle screws could be increased by fixating along the much stronger cortical bone layer, which is not possible with the current rigid and straight bone drills. Inspired by the tsetse fly, a single-plane steerable bone drill was developed. The drill has a flexible transmission using two stacked leaf springs such that...journal article 2023
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van den Berg, A. (author), de Vries, B. (author), Breedveld, Z.A. (author), van Mierlo, A.M.A. (author), Tijhuis, M.J. (author), Marchal Crespo, L. (author)Immersive Virtual Reality (IVR) has gained popularity in neurorehabilitation for its potential to increase patients’ motivation and engagement. A crucial yet relatively unexplored aspect of IVR interfaces is the patients’ representation in the virtual world, such as with an avatar. A higher level of embodiment over avatars has been shown to...journal article 2023
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Fung-A-Jou, Zola (author), Bloemberg, J. (author), Breedveld, P. (author)Needles are commonly used in medical procedures. However, current needle designs have some disadvantages. Therefore, a new generation of hypodermic needles and microneedle patches drawing inspiration from mechanisms found in nature (i.e. bioinspiration) is being developed. In this systematic review, 80 articles were retrieved from Scopus, Web...journal article 2023
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Lussenburg, K.M. (author), van Starkenburg, R.I.B. (author), Bruins, Mathijs (author), Sakes, A. (author), Breedveld, P. (author)Parts produced with metal additive manufacturing often suffer from a poor surface finish. Surface finishing techniques are effective to improve the quality of 3D printed surfaces, however they have as downsides that they also slightly change the geometry of the part, in an unpredictable way. This effect on the geometrical features of complex...journal article 2023
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Kortman, V.G. (author), Sakes, A. (author), Endo, Gen (author), Breedveld, P. (author)Gripping slippery and flexible tissues during minimal invasive surgery (MIS) is often challenging using a conventional tissue gripper. A force grip has to compensate for the low friction coefficient between the gripper’s jaws and the tissue surface. This study focuses on the development of a suction gripper. This device applies a pressure...journal article 2023
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Lussenburg, K.M. (author), Scali, M. (author), Sakes, A. (author), Breedveld, P. (author)Stereolithography is emerging as a promising additive manufacturing technology for a range of applications in the medical domain. However, for miniature, medical devices such as those used in ophthalmic surgery, a number of production challenges arise due to the small size of the components. In this work, we investigate the challenges of...journal article 2022
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Culmone, C. (author), Jager, D.J. (author), Breedveld, P. (author)With the increase in Natural Orifice Transluminal Endoscopic Surgery procedures, there is an increasing demand for surgical instruments with additional degrees of freedom, able to travel along tortuous pathways and guarantee dexterity and high accuracy without compromising the surrounding environment. The implementation of follow-the-leader...journal article 2022
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Culmone, C. (author), van Starkenburg, R.I.B. (author), Smit, G. (author), Breedveld, P. (author)In laparoscopy, a small incision size improves the surgical outcome but increases at the same time the rigidity of the instrument, with consequent impairment of the surgeon’s maneuverability. Such reduction introduces new challenges, such as the loss of wrist articulation or the impossibility of overcoming obstacles. A possible approach is using...journal article 2022
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Oud, Michelle (author), Breedveld, Sebastiaan (author), Giżyńska, Marta (author), Kroesen, Michiel (author), Hutschemaekers, Stefan (author), Habraken, S.J.M. (author), Petit, Steven (author), Perko, Z. (author), Heijmen, Ben (author), Hoogeman, M.S. (author)Background and purpose: In intensity modulated proton therapy (IMPT), the impact of setup errors and anatomical changes is commonly mitigated by robust optimization with population-based setup robustness (SR) settings and offline replanning. In this study we propose and evaluate an alternative approach based on daily plan selection from...journal article 2022
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de Kater, E.P. (author), Sakes, A. (author), Bloemberg, J. (author), Jager, D.J. (author), Breedveld, P. (author)Tissue transport is a challenge during Minimally Invasive Surgery (MIS) with the current suction-based instruments as the increasing length and miniaturisation of the outer diameter requires a higher pressure. Inspired by the wasp ovipositor, a slender and bendable organ through which eggs can be transported, a flexible transport mechanism for...journal article 2021
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Culmone, C. (author), Lussenburg, K.M. (author), Alkemade, J.P.E. (author), Smit, G. (author), Sakes, A. (author), Breedveld, P. (author)In the field of medical instruments, additive manufacturing allows for a drastic reduction in the number of components while improving the functionalities of the final design. In addition, modifications for users’ needs or specific procedures become possible by enabling the production of single customized items. In this work, we present the...journal article 2021
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van Assenbergh, S.P. (author), Culmone, C. (author), Breedveld, P. (author), Dodou, D. (author)Current surgical grippers rely on friction grip, where normal loads (i.e. pinch forces) are translated into friction forces. Operating errors with surgical grippers are often force-related, including tissue slipping out of the gripper because of too low pinch forces and tissue damaging due to too high pinch forces. Here, we prototyped a...journal article 2021
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Cuellar Lopez, J.S. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author), Breedveld, P. (author), Smit, G. (author)Various upper-limb prostheses have been designed for 3D printing but only a few of them are based on bio-inspired design principles and many anatomical details are not typically incorporated even though 3D printing offers advantages that facilitate the application of such design principles. We therefore aimed to apply a bio-inspired approach...journal article 2021
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Ali, A. (author), Szili-Torok, Tamas (author), Stijnen, Marco (author), Breedveld, P. (author), Dodou, D. (author)Purpose: In previous studies we developed two mechanical prototypes of steerable catheters: the Sigma, which uses joysticks to actuate two steerable tip segments, and the Epsilon, which has a handle that is an enlarged version of the tip. In this study, we present a first performance evaluation of the prototypes in the cardiac environment....journal article 2020
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Oud, Michelle (author), Kolkman-Deurloo, Inger Karine (author), Mens, J.W. (author), Lathouwers, D. (author), Perko, Z. (author), Heijmen, Ben (author), Breedveld, Sebastiaan (author)Purpose: To develop and evaluate a fast, automated multi-criterial treatment planning approach for adaptive high-dose-rate (HDR) intracavitary + interstitial brachytherapy (BT) for locally advanced cervical cancer. Methods and materials: Twenty-two previously delivered single fraction MRI-based HDR treatment plans (SF<sub>clin</sub>) were...journal article 2020