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Betjes, M.A. (author), Zheng, X.Z. (author), Kok, R.N.U. (author), van Zon, Jeroen S. (author), Tans, S.J. (author)Organoids have emerged as powerful model systems to study organ development and regeneration at the cellular level. Recently developed microscopy techniques that track individual cells through space and time hold great promise to elucidate the organizational principles of organs and organoids. Applied extensively in the past decade to embryo...review 2021
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Santos, Luis Felipe de Paula (author), Alderliesten, R.C. (author), Kok, Winand (author), Ribeiro, Bruno (author), de Oliveira, Juliana Bovi (author), Costa, Michelle Leali (author), Botelho, Edson Cocchieri (author)The use of carbon nanotube buckypapers (BP) has boosted their use in polymeric composites. However, their low permeability makes processing difficult and limits their use. This work's essential contribution is to define the best parameters to process the buckypapers through vacuum filtration technique and the use of electrospun poly (ether...journal article 2021
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Marijnissen, Richard J.C. (author), Kok, M. (author), Kroeze, Carolien (author), van Loon-Steensma, J.M. (author)In this paper the safety of a double-dike system (or twin dikes) is assessed. Such a system consist of two parallel lines of flood defences. During storms the combined strength of the parallel flood defences must prevent flooding of the hinterland. A culvert can be implemented for the tidal exchange of sea water to enable new land-uses in the...journal article 2021
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Eckhoff, Karsten (author), Kok, M. (author), Lucia, Sergio (author), Seel, Thomas (author)Inertial measurement units are commonly used in a growing number of application fields to track or capture motions of kinematic chains, such as human limbs, exoskeletons or robotic actuators. A major challenge is the presence of magnetic disturbances that results in unreliable magnetometer readings. Recent research revealed that this problem...journal article 2021
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Khokhani, Paree (author), Rahmani, Nada R. (author), Kok, Anne (author), Öner, F. Cumhur (author), Alblas, Jacqueline (author), Weinans, Harrie (author), Kruyt, Moyo C. (author), Croes, Michiel (author)Therapeutic pathogen recognition receptor (PRR) ligands are reaching clinical practice following their ability to skew the immune response in a specific direction. We investigated the effects of various therapeutic PRR ligands on bone cell differentiation and inflammation. Following stimu-lation, alkaline phosphatase (ALP) activity (Day 10),...journal article 2021
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Kok, G. (author), Pelevic, N. (author), Chiribiri, A. (author), Milidonis, X. (author), Nazir, M. (author), Capstick, M. (author), Drost, S. (author), Poelma, C. (author), Schaeffter, T. (author)In the medical sector, various imaging methodologies or modalities (e.g. MRI, PET, CT) are used to assess the health of various parts of the bodies of patients. One such investigation is the blood flow or perfusion of the heart muscle, expressed as the (blood) flow rate normalized by the mass of the volume of interest. Currently there is no...journal article 2021
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Weygers, Ive (author), Kok, M. (author), Seel, Thomas (author), Shah, Darshan (author), Taylan, Orçun (author), Scheys, Lennart (author), Hallez, Hans (author), Claeys, Kurt (author)Skin-attached inertial sensors are increasingly used for kinematic analysis. However, their ability to measure outside-lab can only be exploited after correctly aligning the sensor axes with the underlying anatomical axes. Emerging model-based inertial-sensor-to-bone alignment methods relate inertial measurements with a model of the joint to...journal article 2021
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Vittorietti, M. (author), Kok, Piet J.J. (author), Sietsma, J. (author), Li, W. (author), Jongbloed, G. (author)Modeling microstructures is an interesting problem not just in materials science, but also in mathematics and statistics. The most basic model for steel microstructure is the Poisson-Voronoi diagram. It has mathematically attractive properties and it has been used in the approximation of single-phase steel microstructures. The aim of this...journal article 2020
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Weygers, Ive (author), Kok, M. (author), Konings, Marco (author), Hallez, Hans (author), De Vroey, Henri (author), Claeys, Kurt (author)The use of inertial measurement units (IMUs) has gained popularity for the estimation of lower limb kinematics. However, implementations in clinical practice are still lacking. The aim of this review is twofold-to evaluate the methodological requirements for IMU-based joint kinematic estimation to be applicable in a clinical setting, and to...review 2020
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Costa, Ana Laura (author), Kok, Sien (author), Korff, M. (author)In the Netherlands, subsidence of peat and clay soils due to (artificial) lowering of the groundwater table and loading of soft soils is commonplace, causing extensive damage to exposed and vulnerable assets. Awareness of subsidence-related damage to buildings has recently increased in the Netherlands, particularly after reported damages due...journal article 2020
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Girrbach, Fabian (author), Kok, M. (author), Zandbergen, Raymond (author), Hageman, Tijmen (author), Diehl, Moritz (author)Robust and accurate pose estimation of moving systems is a challenging task that is often tackled by combining information from different sensor subsystems in a multi-sensor fusion setup. To obtain robust and accurate estimates, it is crucial to respect the exact time of each measurement. Data fusion is additionally challenged when the...conference paper 2020
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Hiemstra, K.S. (author), van Vuren, S. (author), Vinke, Frederik R.S. (author), Jorissen, Richard E. (author), Kok, M. (author)Worldwide, rivers provide important socio-economic and environmental functions and are essential to human well-being. The growing demand of user-functions and the change in river conditions due to large-scale morphology and climate change, increase the pressure on lowland river systems (e.g. Rhine, Meuse, Danube and Mississippi). To ensure a...journal article 2020
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Marijnissen, Richard (author), Esselink, Peter (author), Kok, M. (author), Kroeze, Carolien (author), van Loon-Steensma, J.M. (author)Effective adaptation to sea-level rise is critical for future flood protection. Nature-based solutions including salt marshes have been proposed to naturally enhance coastal infrastructure. A gently sloping grass-covered dike (i.e. Wide Green Dike) can be strengthened with clay accumulating locally in the salt marsh. This study explores the...journal article 2020
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Marijnissen, Richard (author), Kok, M. (author), Kroeze, Carolien (author), van Loon-Steensma, J.M. (author)Integrating natural components in flood defence infrastructure can add resilience to sea-level rise. Natural foreshores can keep pace with sea-level rise by accumulating sediment and attenuate waves before reaching the adjacent flood defences. In this study we address how natural foreshores affect the future need for dike heightening. A...journal article 2020
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Weygers, Ive (author), Kok, M. (author), De Vroey, Henri (author), Verbeerst, Tommy (author), Versteyhe, Mark (author), Hallez, Hans (author), Claeys, Kurt (author)The ability to capture joint kinematics in outside-laboratory environments is clinically relevant. In order to estimate kinematics, inertial measurement units can be attached to body segments and their absolute orientations can be estimated. However, the heading part of such orientation estimates is known to drift over time, resulting in...journal article 2020
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Olsson, Fredrik (author), Kok, M. (author), Seel, Thomas (author), Halvorsen, Kjartan (author)Inertial motion capture relies on accurate sensor-to-segment calibration. When two segments are connected by a hinge joint, for example in human knee or finger joints as well as in many robotic limbs, then the joint axis vector must be identified in the intrinsic sensor coordinate systems. Methods for estimating the joint axis using...journal article 2020
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Milidonis, Xenios (author), Nazir, Muhummad Sohaib (author), Schneider, Torben (author), Capstick, Myles (author), Drost, S. (author), Kok, Gertjan (author), Pelevic, Nikola (author), Poelma, C. (author), Schaeffter, Tobias (author), Chiribiri, Amedeo (author)Purpose: Cardiovascular magnetic resonance first-pass perfusion for the pixel-wise detection of coronary artery disease is rapidly becoming the clinical standard, yet no widely available method exists for its assessment and validation. This study introduces a novel phantom capable of generating spatially dependent flow values to enable...journal article 2020
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van der Krogt, M.G. (author), Klerk, W.J. (author), Kanning, W. (author), Schweckendiek, T. (author), Kok, M. (author)Spatial variability and limited measurements often result in low reliability estimates of geotechnical failure modes of dikes (i.e., earthen flood defences). Required dike reinforcements are usually not executed within a few years after inception, which enables efforts to improve reliability estimates by reducing uncertainty. Often decision...journal article 2020
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Wahlström, Johan (author), Kok, M. (author), Porto Buarque de Gusmão, Pedro (author), Abrudan, Traian E. (author), Trigoni, Niki (author), Markham, Andrew (author)Magneto-inductive navigation is an inexpensive and easily deployable solution to many of today’s navigation problems. By utilizing very low frequency magnetic fields, magneto-inductive technology circumvents the problems with attenuation and multipath that often plague competing modalities. Using triaxial transmitter and receiver coils, it is...journal article 2020
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Curran, A.N. (author), de Bruijn, K.M. (author), Domeneghetti, Alessio (author), Bianchi, Federica (author), Kok, M. (author), Vorogushyn, Sergiy (author), Castellarin, Attilio (author)Reliable hazard analysis is crucial in the flood risk management of river basins. For the floodplains of large, developed rivers, flood hazard analysis often needs to account for the complex hydrology of multiple tributaries and the potential failure of dikes. Estimating this hazard using deterministic methods ignores two major aspects of...journal article 2020