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Puiman, L. (author), Almeida Benalcazar, E.F. (author), Picioreanu, Cristian (author), Noorman, H.J. (author), Haringa, C. (author)Gradients in dissolved gas concentrations are expected to affect the performance of large reactors for anaerobic gas (CO, H2, CO2) fermentation. To study how these gradients, and the dissolved gas concentration level itself, influence the productivity of the desired product ethanol and the product spectrum of C. autoethanogenum, we coupled a CFD...journal article 2024
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Puiman, L. (author), Almeida Benalcazar, E.F. (author), Picioreanu, C. (author), Noorman, H.J. (author), Haringa, C. (author)In large-scale syngas fermentation, strong gradients in dissolved gas (CO, H<sub>2</sub>) concentrations are very likely to occur due to locally varying mass transfer and convection rates. Using Euler-Lagrangian CFD simulations, we analyzed these gradients in an industrial-scale external-loop gas-lift reactor (EL-GLR) for a wide range of...journal article 2023
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Desmond, Peter (author), Huisman, Kees Theo (author), Sanawar, Huma (author), Farhat, Nadia M. (author), Traber, Jacqueline (author), Fridjonsson, Einar O. (author), Johns, Michael L. (author), Flemming, Hans Curt (author), Picioreanu, C. (author), Vrouwenvelder, J.S. (author)The application of membrane technology for water treatment and reuse is hampered by the development of a microbial biofilm. Biofilm growth in micro-and ultrafiltration (MF/UF) membrane modules, on both the membrane surface and feed spacer, can form a secondary membrane and exert resistance to permeation and crossflow, increasing energy demand...journal article 2022
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Puiman, L. (author), Abrahamson, Britt (author), van der Lans, R.G.J.M. (author), Haringa, C. (author), Noorman, H.J. (author), Picioreanu, C. (author)Mass transfer limitations in syngas fermentation processes are mostly attributed to poor solubility of CO and H<sub>2</sub> in water. Despite these assumed limitations, a syngas fermentation process has recently been commercialized. Using large-sale external-loop gas-lift reactors (EL-GLR), CO-rich off-gases are converted into ethanol, with...journal article 2022
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Taylor Parkins, S.K. (author), Murthy, Swathi (author), Picioreanu, C. (author), Kühl, Michael (author)Coral reefs are constructed by calcifying coral animals that engage in a symbiosis with dinoflagellate microalgae harboured in their tissue. The symbiosis takes place in the presence of steep and dynamic gradients of light, temperature and chemical species that are affected by the structural and optical properties of the coral and their...journal article 2021
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Jafari Eshlaghi, M. (author), Vanoppen, M. (author), van Agtmaal, J. M.C. (author), Cornelissen, E. R. (author), Vrouwenvelder, J.S. (author), Verliefde, A. (author), van Loosdrecht, Mark C.M. (author), Picioreanu, C. (author)The economic impact of fouling in spiral wound membranes is not yet well explored. There has been an established assumption that the cost of fouling in membrane processes is significant, but this hypothesis has not been thoroughly evaluated. We conducted an economic analysis on seven full-scale installations, four nanofiltration (NF) and...journal article 2020
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Safdari, Hadiseh (author), Kalirad, Ata (author), Picioreanu, C. (author), Tusserkani, Rouzbeh (author), Goliaei, Bahram (author), Sadeghi, Mehdi (author)The emergence of phenotypic diversity in a population of cells and their arrangement in space and time is one of the most fascinating features of living systems. In fact, understanding multicellularity is unthinkable without explaining the proximate and the ultimate causes of cell differentiation in time and space. Simpler forms of cell...journal article 2020
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Jafari Eshlaghi, M. (author), D'haese, A. (author), Zlopasa, J. (author), Cornelissen, E. R. (author), Vrouwenvelder, J.S. (author), Verbeken, K. (author), Verliefde, A. (author), van Loosdrecht, Mark C.M. (author), Picioreanu, C. (author)Chemical cleaning is vital for the optimal operation of membrane systems. Membrane chemical cleaning protocols are often developed in the laboratory flow cells (e.g., Membrane Fouling Simulator (MFS)) using synthetic feed water (nutrient excess) and short experimental time of typically days. However, full-scale Reverse Osmosis (RO) membranes...journal article 2020
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Prades, Lledó (author), Fabbri, Stefania (author), Dorado, Antonio D. (author), Gamisans, Xavier (author), Stoodley, Paul (author), Picioreanu, C. (author)Experimental data showed that high-speed microsprays can effectively disrupt biofilms on their support substratum, producing a variety of dynamic reactions such as elongation, displacement, ripple formation, and fluidization. However, the mechanics underlying the impact of high-speed turbulent flows on biofilm structure is complex under such...journal article 2020
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van Tatenhove-Pel, R.J. (author), Rijavec, Tomaž (author), Lapanje, Aleš (author), van Swam, Iris (author), Zwering, Emile (author), Hernandez-Valdes, Jhonatan A. (author), Kuipers, Oscar P. (author), Picioreanu, C. (author), Teusink, Bas (author), Bachmann, Herwig (author)Metabolic interactions between cells affect microbial community compositions and hence their function in ecosystems. It is well-known that under competition for the exchanged metabolite, concentration gradients constrain the distances over which interactions can occur. However, interaction distances are typically quantified in two-dimensional...journal article 2020
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Jafari, Morez (author), Derlon, Nicolas (author), Desmond, Peter (author), van Loosdrecht, Mark C.M. (author), Morgenroth, Eberhard (author), Picioreanu, C. (author)Poroelastic fluid-structure interaction models were coupled to experimental data to determine the effects of biofilm spatial distribution of mechanical and hydraulic properties on the biofilm hydraulic resistance and compressibility in membrane filtration processes. Biofilms were cultivated on ultrafiltration membranes for 20 and 30 days...journal article 2019
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Jafari, Morez (author), Desmond, Peter (author), van Loosdrecht, Mark C.M. (author), Derlon, Nicolas (author), Morgenroth, Eberhard (author), Picioreanu, C. (author)Biofilm formation in membrane systems negatively impacts the filtration system performances. This study evaluated how biofilm compression driven by permeate flow increases the hydraulic resistance and leads to reduction in permeate flux. We analysed the effect of biofilm compression on hydraulic resistance and permeate flux through...journal article 2018
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Picioreanu, C. (author), Blauert, Florian (author), Horn, Harald (author), Wagner, Michael (author)The advantage of using non-invasive imaging such as optical coherence tomography (OCT) to asses material properties from deformed biofilm geometries can be compromised by the assumptions made on fluid forces acting on the biofilm. This study developed a method for the determination of elastic properties of biofilms by modelling the biofilm...journal article 2018
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Roggo, Clémence (author), Picioreanu, C. (author), Richard, Xavier (author), Mazza, Christian (author), van Lintel, Harald (author), van der Meer, Jan Roelof (author)Whole-cell bacterial bioreporters are proposed as alternatives to chemical analysis of, for example, pollutants in environmental compartments. Commonly based on reporter gene induction, bioreporters produce a detectable signal within 30 min to a few hours after exposure to the chemical target, which is impractical for applications aiming at a...journal article 2018
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Janulevicius, A. (author), Van Loosdrecht, M.C.M. (author), Picioreanu, C. (author)Myxobacteria are social bacteria that upon starvation form multicellular fruiting bodies whose shape in different species can range from simple mounds to elaborate tree-like structures. The formation of fruiting bodies is a result of collective cell movement on a solid surface. In the course of development, groups of flexible rod-shaped cells...journal article 2015
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Celler, K. (author), Hödl, I. (author), Simone, A. (author), Battin, T.J. (author), Picioreanu, C. (author)Diatoms often dominate planktonic communities in the ocean and phototrophic biofilms in streams and rivers, greatly contributing to global biogeochemical fluxes. In pelagic ecosystems, these microscopic algae can form chain-like microcolonies, which seem advantageous for nutrient uptake and protect against grazing, and at the same time reduce...journal article 2014
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Ofi?eru, I.D. (author), Bellucci, M. (author), Picioreanu, C. (author), Lavric, V. (author), Curtis, T.P. (author)A simple “first generation” multi-scale computational model of the formation of activated sludge flocs at micro-scale and reactor performance at macro-scale is proposed. The model couples mass balances for substrates and biomass at reactor scale with an individual-based approach for the floc morphology, shape and micro-colony development. Among...journal article 2013
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Kampschreur, M.J. (author), Kleerebezem, R. (author), Picioreanu, C. (author), Bakken, L. (author), Bergaust, L. (author), De Vries, S. (author), Jetten, M.S.M. (author), Van Loosdrecht, M.C.M. (author)A metabolic network model for facultative denitrification was developed based on experimental data obtained with Agrobacterium tumefaciens. The model includes kinetic regulation at the enzyme level and transcription regulation at the enzyme synthesis level. The objective of this work was to study the key factors regulating the metabolic response...journal article 2012
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- Kampschreur, M.J. (author), Kleerebezem, R. (author), Picioreanu, C. (author), Bakken, L. (author), Bergaust, L. (author), De Vries, S. (author), Jetten, M.S.M. (author), Van Loosdrecht, M.C.M. (author) journal article 2012
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Celler, K. (author), Picioreanu, C. (author), Van Loosdrecht, M.C.M. (author), Van Wezel, G.P. (author)Successful application of a computational model for rational design of industrial Streptomyces exploitation requires a better understanding of the relationship between morphology—dictated by microbial growth, branching, fragmentation and adhesion—and product formation. Here we review the state-of-the-art in modeling of growth and product...journal article 2012
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