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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Roos, R. (author), Van Steenbergen, M.J. (author), Kaaijk, C.N.J. (author), Koster-Ammerlaan, M.J.J. (author), De Leege, P.F.A. (author), Hennink, W.E. (author), Van het Schip, A.D. (author), Krijger, G.C. (author)Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (166Ho-PLLA-MS) are a novel microdevice for intra-arterial radioembolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the 166Ho-PLLA-MS. The degree of damage is dependent on the...journal article 2009
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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Wit, T.C. (author), Seppenwoolde, J.H. (author), Krijger, G.C. (author), Seevinck, P.R. (author), Huisman, A. (author), Zonneneberg, B.A. (author), Van den Ingh, T.S.G.A.M. (author), Van het Schip, A.D. (author)Purpose The aim of this study is to evaluate the toxicity of holmium-166 poly(l-lactic acid) microspheres administered into the hepatic artery in pigs. Methods Healthy pigs (20–30 kg) were injected into the hepatic artery with holmium-165-loaded microspheres (165HoMS; n?=?5) or with holmium-166-loaded microspheres (166HoMS; n?=?13). The...journal article 2008