Towards clinically feasible iterative probabilistic treatment planning of IMPT: using polynomial chaos expansion

Radiotherapy is among the most popular modalities used for cancer treatment. Proton therapy is a promising kind of radiotherapy, which uses protons characteristic maximum dose deposition to a specific tissue depth, for precise tumor irradiation. However, in comparison to conventional photon radiotherapy, proton therapy is sensitive to more...

The increased risk of post-treatment contrast-enhancing brain lesion in IMPT of glioma, and the mitigation thereof in treatment planning

Proton radiotherapy has a dosimetric advantage over photon therapy to spare healthy tissue closely positioned to the tumor mainly due to the absent exit dose. In The Netherlands, the Proton therapy centers currently take a relative biological effectiveness (RBE) of 1.1 compared to photons to deliver an iso-effective treatment. However, initial...

FLASH optimisation in clinical IMPT treatment planning: optimisation and evaluation of stereotactic lung treatment plans with proton transmission beams

Radiotherapy (RT) is an important modality in treatment against cancer. Developments in this modality are necessary for improvement of patient complications and survival. Aside from fractionation and precise irradiation, FLASH radiotherapy could be a third way to significantly increase the therapeutic window of radiotherapy.The FLASH effect is a...