Explainable Survival Analysis: for Urothelial Cancer

Survival analysis is a statistical method used to predict when an event will occur. Machine learning survival models have been used in many cancer studies. However, machine learning models may not always be interpretable. The current lack of research for explainable survival analysis for urothelial cancer prompted this study. This study offers...

Causal inference with multi-state models, applied on estimating the effect of the IUI treatment timing for couples with unexplained subfertility

This thesis examines statistical methods to find the right timing of intrauterine insemination treatment relative to the start of the follow-up of the couples. Intrauterine insemination is a fertility treatment conducted by injecting refined sperm into a woman's uterus. Lots of research has been done on timing of steps within one IUI cycle....

Service-life Pavement Performance Simulation: Capturing the Influence of Traffic Flows by Big Data Analysis

An ideal road management system requires a real-time assessment of pavement performance. But there are many root causes of the status quo that the expectation and the system have not been achieved yet. One of them is the monitoring system. In the Netherlands, the measurement is carried out once a year because of the budget and also because it is...

Bootstrapping in the Cox-model with interval censored observations

In this study the interval censoring case 2 model combined with the Cox model is considered. The event-time distribution function is modeled nonparametrically. Two algorithms are proposed to estimate the event-time distribution function together with the Cox coefficients. Kernel smoothing is applied to the non-parametric MLE of the event-time...

Data Informed Decision Making: Cardiovascular Disease Prevention

Cardiovascular diseases are considered as one the deadliest disease and have also been the most prominent health burden around the world and particularly in the Netherlands. Enormously mitigation has been done to reduce the death burden, by improving the quality of health care services and research related to cardiovascular diseases. One...

Understanding the role of IoT end users in Miria-Like bot remediation

Malicious software such as botnets are a threat to society and increasingly so through Internet of Things (IoT) devices. The large volume, pervasiveness and high vulnerability of IoT devices make them low hanging fruit for malicious actors. Currently, the biggest threat for insecure IoT devices is Mirai, a botnet which is deployed for DDoS...

Reliability modelling for Aircraft Component Availability Management

Global and local aviation traffic is growing while economic and performance pressures on the industry are increasing. As a consequence, airlines try to maximise their fleet utilization. Airline operators and Maintenance, Repair and Overhaul (MRO) providers therefore require as much insight as possible in factors affecting component reliability...

Grey Matter Age Prediction as a Biomarker for Risk of Dementia: A Population-based Study

The gap between predicted brain age and chronological age could serve as biomarker for early-stage neurodegeneration and as potentially as a risk indicator for dementia. We assess the utility of this age gap as a risk biomarker for incident dementia in a general elderly population. The brain age is estimated from longitudinal brain magnetic...

Transformer Condition Assessment & Survival Model

Managing electrical distribution assets entails making the decision on how to proceed with an ageing asset. The three options that asset managers have are run to fail, perform maintenance or repairs and lastly to replace. This decision making process is becoming incrementally more important due to the threat of replacement waves. This a...