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The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics

Jansen, Imke (author), Cahalane, Rachel (author), Hengst, Ranmadusha (author), Akyildiz, A.C. (author), Farrell, Eric (author), Gijsen, F.J.H. (author), Aikawa, Elena (author), van der Heiden, Kim (author), Wissing, Tamar (author)

The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovascular events. In essence, the rupture of the plaque cap is a mechanical event, which occurs when the local stress exceeds the local tissue strength. However, due to inter- and intra-cap heterogeneity, the resulting ultimate...

review 2024

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Serial RV wall stress measurements: association with right ventricular function in repaired Tetralogy of Fallot patients

Minderhoud, Savine C.S. (author), Hirsch, Alexander (author), Marin, Francesca (author), Kardys, Isabella (author), Rodriguez Matas, Jose Felix (author), Chiastra, Claudio (author), Roos-Hesselink, Jolien W. (author), Wentzel, Jolanda J. (author), Helbing, Willem A. (author), Akyildiz, A.C. (author)

Background: Optimal timing of pulmonary valve replacement (PVR) in Tetralogy of Fallot (TOF) patients remains challenging. Ventricular wall stress is considered to be an early marker of right ventricular (RV) dysfunction.<br/><br/>Objectives: To investigate the association of RV wall stresses and their change over time with functional parameters...

journal article 2023

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Tensile and Compressive Mechanical Behaviour of Human Blood Clot Analogues

Cahalane, R.M.E. (author), de Vries, J.J. (author), de Maat, Moniek P.M. (author), van Gaalen, Kim (author), van Beusekom, Heleen M. (author), van der Lugt, Aad (author), Fereidoonnezhad, B.F. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)

Endovascular thrombectomy procedures are significantly influenced by the mechanical response of thrombi to the multi-axial loading imposed during retrieval. Compression tests are commonly used to determine compressive ex vivo thrombus and clot analogue stiffness. However, there is a shortage of data in tension. This study compares the tensile...

journal article 2023

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Mechanical wall stress and wall shear stress are associated with atherosclerosis development in non-calcified coronary segments

Tziotziou, Aikaterini (author), Hartman, Eline (author), Korteland, Suze Anne (author), van der Lugt, Aad (author), van der Steen, A.F.W. (author), Daemen, Joost (author), Bos, Daniel (author), Wentzel, Jolanda (author), Akyildiz, A.C. (author)

Background and aims: Atherosclerotic plaque onset and progression are known to be affected by local biomechanical factors. While the role of wall shear stress (WSS) has been studied, the impact of another biomechanical factor, namely mechanical wall stress (MWS), remains poorly understood. In this study, we investigated the association of MWS...

journal article 2023

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Local characterization of collagen architecture and mechanical failure properties of fibrous plaque tissue of atherosclerotic human carotid arteries

Torun, Su Guvenir (author), Munoz, Pablo de Miguel (author), Crielaard, Hanneke (author), Verhagen, Hence J.M. (author), Kremers, Gert Jan (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)

Atherosclerotic plaque rupture in carotid arteries is a major cause of cerebrovascular events. Plaque rupture is the mechanical failure of the heterogeneous fibrous plaque tissue. Local characterization of the tissue's failure properties and the collagen architecture are of great importance to have insights in plaque rupture for clinical...

journal article 2023

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Cross-Sectional Validation of a Novel Computed Tomography-Based Carotid Mean Calcium Density Measurement

Cahalane, R.M.E. (author), Akyildiz, A.C. (author), Kavousi, Maryam (author), Vernooij, Meike W. (author), Ikram, M. Kamran (author), Gijsen, F.J.H. (author), Bos, Daniel (author)

Background The purpose of this study was to validate a technique for measuring mean calcium density and to determine associations of cardiovascular risk factors with carotid calcium density. Methods and Results We performed a cross-sectional study in a random sample of 100 stroke-free participants from the population-based Rotterdam Study....

journal article 2023

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A tissue-engineered model of the atherosclerotic plaque cap: Toward understanding the role of microcalcifications in plaque rupture

Jansen, Imke (author), Crielaard, Hanneke (author), Wissing, Tamar (author), Bouten, Carlijn (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author), Farrell, Eric (author), van der Heiden, Kim (author)

Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has been suggested, through computational models, that the presence of microcalcifications in the atherosclerotic cap can increase the risk of cap rupture. However, the experimental confirmation of this hypothesis is still lacking. In this study,...

journal article 2023

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Thrombus mechanics: How can we contribute to improve diagnostics and treatment?

Migliavacca, Francesco (author), Luraghi, G. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)

contribution to periodical 2022

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Intravascular optical coherence elastography

Wang, Tianshi (author), Pfeiffer, Tom (author), Akyildiz, A.C. (author), van Beusekom, Heleen M.M. (author), Huber, Robert (author), van der Steen, A.F.W. (author), Soest, Gijs Van (author)

Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using a 1.1 mm motorized catheter and a 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure...

journal article 2022

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Multicomponent material property characterization of atherosclerotic human carotid arteries through a Bayesian Optimization based inverse finite element approach

Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), de Korte, Chris L. (author), van der Steen, Antonius F.W. (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author)

Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid...

journal article 2022

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Morphological Subtypes of Intracranial Internal Carotid Artery Arteriosclerosis and the Risk of Stroke

Van Den Beukel, Tim C. (author), Van Der Toorn, Janine E. (author), Vernooij, Meike W. (author), Kavousi, Maryam (author), Akyildiz, A.C. (author), De Jong, Pim A. (author), Van Der Lugt, Aad (author), Ikram, M. Kamran (author), Bos, Daniel (author)

Background: Accumulating evidence highlights the existence of distinct morphological subtypes of intracranial carotid arteriosclerosis. So far, little is known on the prevalence of these subtypes and subsequent stroke risk in the general population. We determined the prevalence of morphological subtypes of intracranial arteriosclerosis and...

journal article 2022

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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Crielaard, Hanneke (author), Guvenir Torun, Su (author), Wissing, Tamar B. (author), de Miguel Muñoz, Pablo (author), Kremers, Gert Jan (author), Gijsen, F.J.H. (author), Van Der Heiden, Kim (author), Akyildiz, A.C. (author)

The rupture of atherosclerotic plaques in coronary and carotid arteries is the primary cause of fatal cardiovascular events. However, the rupture mechanics of the heterogeneous, highly collagenous plaque tissue, and how this is related to the tissue's fibrous structure, are not known yet. Existing pipelines to study plaque mechanics are...

journal article 2022

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Seven-year clinical and mechanical follow-up of a Tetralogy of Fallot patient with severe pulmonary regurgitation

Minderhoud, Savine C.S. (author), Akyildiz, A.C. (author), Hirsch, Alexander (author), Helbing, Willem A. (author)

journal article 2022

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Morphometric and Mechanical Analyses of Calcifications and Fibrous Plaque Tissue in Carotid Arteries for Plaque Rupture Risk Assessment

Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)

Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...

journal article 2021

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Mechanical Characterization of Thrombi Retrieved with Endovascular Thrombectomy in Patients with Acute Ischemic Stroke

Boodt, Nikki (author), Snouckaert Van Schauburg, Philip R.W. (author), Hund, Hajo M. (author), Fereidoonnezhad, B.F. (author), McGarry, J. Patrick (author), Akyildiz, A.C. (author), Van Es, Adriaan C.G.M. (author), Van Der Lugt, Aad (author), Gijsen, F.J.H. (author)

Background and Purpose: Mechanical properties of thromboemboli play an important role in the efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke. However, very limited data on mechanical properties of human stroke thrombi are available. We aimed to mechanically characterize thrombi retrieved with EVT, and to assess the...

journal article 2021

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Multicomponent Mechanical Characterization of Atherosclerotic Human Coronary Arteries: An Experimental and Computational Hybrid Approach

Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), Gandini, Giulia (author), Berselli, Irene (author), Codazzi, Veronica (author), de Korte, Chris L. (author), van der Steen, A.F.W. (author), Migliavacca, Francesco (author), Chiastra, Claudio (author), Akyildiz, A.C. (author)

Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of...

journal article 2021

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A Framework for Local Mechanical Characterization of Atherosclerotic Plaques: Combination of Ultrasound Displacement Imaging and Inverse Finite Element Analysis

Akyildiz, A.C. (author), Hansen, Hendrik H.G. (author), Nieuwstadt, Harm A. (author), Speelman, Lambert (author), De Korte, Chris L. (author), van der Steen, A.F.W. (author), Gijsen, Frank J H (author)

Biomechanical models have the potential to predict plaque rupture. For reliable models, correct material properties of plaque components are a prerequisite. This study presents a new technique, where high resolution ultrasound displacement imaging and inverse finite element (FE) modeling is combined, to estimate material properties of plaque...

journal article 2016

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Effects of intima stiffness and plaque morphology on peak cap stress

Akyildiz, A.C. (author), Speelman, L. (author), Van Brummelen, H. (author), Gutiérrez, M.A. (author), Virmani, R. (author), Van der Lugt, A. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)

Background: Rupture of the cap of a vulnerable plaque present in a coronary vessel may cause myocardial infarction and death. Cap rupture occurs when the peak cap stress exceeds the cap strength. The mechanical stress within a cap depends on the plaque morphology and the material characteristics of the plaque components. A parametric study was...

journal article 2011

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Effects of intima stiffness and plaque morphology

Akyildiz, A.C. (author), Speelman, L (author), van Brummelen, EH (author), Gutierrez De La Merced, M.A. (author), Virmani, R (author), van der Lugt, A. (author), van der Steen, AFW (author), Wentzel, JJ (author), Gijsen, FJH (author)

journal article 2011

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Experimental investigation of pressure distribution on a rectangular tank due to the liquid sloshing

Akyildiz, H. (author), Unal, Erdem (author)

journal article 2005