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van der Vos, K.E. (author), Vis, D.J. (author), Nevedomskaya, E. (author), Kim, Y. (author), Choi, W. (author), McConkey, D. (author), Wessels, L.F.A. (author), van Rhijn, B.W.G. (author), Zwart, W. (author), van der Heijden, M.S. (author)Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease that often recurs despite aggressive treatment with neoadjuvant chemotherapy and (radical) cystectomy. Basal and luminal molecular subtypes have been identified that are linked to clinical characteristics and have differential sensitivities to chemotherapy. While it has been...journal article 2020
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Kim, Yongsoo (author), Bismeijer, Tycho (author), Zwart, Wilbert (author), Wessels, L.F.A. (author), Vis, Daniel J. (author)Integrative analyses that summarize and link molecular data to treatment sensitivity are crucial to capture the biological complexity which is essential to further precision medicine. We introduce Weighted Orthogonal Nonnegative parallel factor analysis (WON-PARAFAC), a data integration method that identifies sparse and interpretable factors....journal article 2019